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Spero Therapeutics

(NASDAQ) SPRO

Current Price$1.47
Market Cap$91.48MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.
Since IPO (2017)-86%
5 Year-89%
1 Year-36%
1 Month-25%
Spero Therapeutics last closing stock price
MetricPriceDate
Last closeUSD 1.582026-07-17
Spero Therapeutics stock price return by period
PeriodPrice returnPrice at period startPeriod start date
1 week-24.76%USD 2.102026-07-10
1 month-25.12%USD 2.112026-06-17
3 month-42.55%USD 2.752026-04-17
Year to date-32.19%USD 2.332025-12-31
1 year-36.29%USD 2.482025-07-17
3 year+5.33%USD 1.502023-07-18
5 year-89.05%USD 14.432021-07-16
Since inception-86.26%USD 11.502017-11-02

Spero Therapeutics Financials at a Glance

Market Cap

$91.48MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Revenue (TTM)

$54.77M

Net Income (TTM)

$15.24M

EPS (TTM)

$0.24

P/E Ratio

6.48

Dividend

$0.00

Beta (Volatility)

0.93 (Low)

Price

$1.47

Volume

700,966.921

Open

$1.57

Previous Close

$1.58

Daily Range

$1.46 - $1.57

52-Week Range

$1.46 - $3.08

Estimated Earnings Date

Aug 11, 2026

SPRO News

rising chart chalkboard

Why Spero Therapeutics Stock Is Up 15% Today

James BrumleyJul 1, 2021
2 scientists in lab

Why Spero Therapeutics Shares Are Sliding Today

Keith SpeightsSep 11, 2020

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About Spero Therapeutics

Spero develops oral antibiotics for hard-to-treat bacterial infections. Its main drug helps adults with complicated urinary tract infections.

What’s in the Spero Medicine Cabinet?

  • Tebipenem pivoxil hydrobromide (HBr): Oral antibiotic for adults with complicated urinary tract infections.
  • SPR720: Oral antibiotic for rare lung infections; development suspended in 2025.
  • SPR206: Intravenous drug for drug-resistant hospital infections; development discontinued in 2025.
  • Collaboration Revenue: Payments from partners like GSK for drug development milestones; main revenue source.
  • Grant Revenue: Funding from U.S. government agencies for research.

Growth Spurts and Strategic Moves

  • Partnered with GSK in 2022 to develop and commercialize tebipenem HBr outside Asia.
  • Signed licensing deals with Meiji Seika Pharma (tebipenem HBr) and Everest Medicines (SPR206) in Asia.
  • Collaborated with Bill & Melinda Gates Medical Research Institute for SPR720 lung infection research.
  • Restructured in October 2024, cutting workforce by 39% and focusing on tebipenem HBr.
  • Received $23.8 million milestone payment from GSK in Q3 2025, completing a $95 million development milestone.

Why Spero Stands Out (Without the Lab Coat)

Spero focuses on oral antibiotics for infections that usually require hospital IV drugs. Its business model relies on partnerships and government funding, not direct product sales. The company targets high-need areas where few oral treatments exist.

Five Things You Need to Know

  • Revenue was $12 million in Q2 2025, up 96.1% from Q2 2024.
  • Net loss was $2 million in Q2 2025, improving 87.2% year-over-year.
  • Tebipenem HBr accounted for 83.1% of Q2 2025 revenue.
  • Cash and equivalents were $31.2 million as of June 30, 2025.
  • Full-time employees numbered 32 at the end of Q2 2025.

Bottom Line

Spero has shifted to focus on one main oral antibiotic and partnerships. Its business depends on milestone payments and government grants, not product sales.

AI Generated • Apr 16, 2026

Industry

Biotechnology

Sector

Health Care

Employees

25

CEO

Esther Rajavelu, MBA

Website

www.sperotherapeutics.com

Headquarters

Cambridge, MA 02139, US

SPRO Financials

Key Financial Metrics (TTM)

Gross Margin

100.00%

Operating Margin

24.66%

Net Income Margin

27.82%

Return on Equity

35.58%

Return on Capital

-0.04%

Return on Assets

25.81%

Earnings Yield

15.43%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$91.48MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Shares Outstanding

57.90M

Volume

700.97K

Avg. Volume

1.23M

Financials (TTM)

Gross Profit

$54.77M

Operating Income

$13.51M

EBITDA

$14.89M

Operating Cash Flow

$7.24M

Capital Expenditure

$0.00

Free Cash Flow

$7.24M

Cash & ST Invst.

$56.13M

Total Debt

$2.47M

Spero Therapeutics Performance Analysis

Spero Therapeutics annual revenue and year-over-year revenue growth by fiscal year
Fiscal yearPeriod endRevenueYoY growth
20222022-12-31USD 48,579,0001482.4%
20232023-12-31USD 96,735,00099.1%
20242024-12-31USD 27,396,000-71.7%
20252025-12-31USD 59,619,000117.6%
Spero Therapeutics sequential (quarter-over-quarter) revenue growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-30100.9%
Q32025-09-30-74.2%
Q42025-12-311201.1%
Q12026-03-31-99.3%
Spero Therapeutics annual diluted earnings per share and year-over-year EPS growth by fiscal year
Fiscal yearPeriod endDiluted EPSYoY growth
20222022-12-31USD -1.23-57.5%
20232023-12-31USD 0.43N/A
20242024-12-31USD -1.27N/A
20252025-12-31USD 0.15N/A
Spero Therapeutics sequential (quarter-over-quarter) diluted earnings per share growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-3087.9%
Q32025-09-30-329.0%
Q42025-12-31507.7%
Q12026-03-31-124.5%

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name
Q1 2026YOY CHG

Revenue

$258.00K

-95.6%

Gross Profit

$258.00K

+103.3%

Gross Margin

100.00%

N/A

Market Cap

$91.48MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

N/A

Market Cap/Employee

$3.66M

N/A

Employees

25

N/A

Net Income

-$7.20M

+48.1%

EBITDA

-$7.20M

+50.5%

Quarterly Fundamentals

Name
Q1 2026YOY CHG

Total Cash

$56.13M

+14.8%

Total Debt

$2.47M

-37.5%

Accounts Receivable

$44.00K

-99.8%

Inventory

$0.00

N/A

Long Term Debt

$507.00K

-76.6%

Short Term Debt

$1.97M

+9.6%

Return on Assets

25.81%

N/A

Return on Invested Capital

25.23%

N/A

Free Cash Flow

$15.86M

+496.4%

Operating Cash Flow

$15.86M

+496.4%

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Questions About SPRO

What is the current price of Spero Therapeutics?

Spero Therapeutics is trading at $1.47 per share.

What is the 52-week range for Spero Therapeutics?

Over the past 52 weeks, Spero Therapeutics has traded between $1.46 and $3.08.

How much debt does Spero Therapeutics have?

As of the most recent reporting period, Spero Therapeutics reported total debt of $2.47M.

How much cash does Spero Therapeutics have on hand?

Spero Therapeutics reported $56.13M in cash and cash equivalents in its most recent financial results.

What is Spero Therapeutics’s dividend yield?

Spero Therapeutics does not currently have a dividend yield.

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