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| 1 Year | 5 Year | 5 Year Annualized | Since IPO | |
|---|---|---|---|---|
| SYRE | -33.44% | -88.35% | -34.93% | -93% |
| S&P | +16.23% | +94.45% | +14.22% | +229% |
Aeglea Biotherapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. Its product Pegzilarginase, is in a Phase 3 pivotal trial for the treatment of Arginase 1 Deficiency. The company was founded by George Georgiou and David G. Lowe in December 2013 and is headquartered in Austin, TX.
| Q2 2025 | YOY Change | |
|---|---|---|
| Revenue | $0.00M | 0.0% |
| Gross Profit | $0.00M | 0.0% |
| Market Cap | $903.49M | -24.3% |
| Market Cap / Employee | $10.38M | 0.0% |
| Employees | 87 | 0.0% |
| Net Income | -$36.72M | -37.2% |
| EBITDA | -$51.94M | -17.6% |
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| Q2 2025 | YOY Change | |
|---|---|---|
| Net Cash | $81.66M | 80.9% |
| Accounts Receivable | $0.00M | 0.0% |
| Inventory | 0 | 0.0% |
| Q2 2025 | YOY Change | |
|---|---|---|
| Long Term Debt | $0.00M | 0.0% |
| Short Term Debt | $0.00M | 0.0% |
| Q2 2025 | YOY Change | |
|---|---|---|
| Return On Assets | -34.91% | -60.7% |
| Return On Invested Capital | -69.72% | 36.5% |
| Q4 2024 | YOY Change | |
|---|---|---|
| Free Cash Flow | -$37.53M | -20.9% |
| Operating Free Cash Flow | -$46.56M | 25.2% |
| Metric | Q2 2024 | Q3 2024 | YoY Change | ||
|---|---|---|---|---|---|
| Price to Earnings | 25.42 | 3.19 | - | ||
| Price to Book | 6.83 | 6.97 | 2.69 | 2.76 | -110.47% |
| Price to Sales | 379.10 | 2012.97 | - | ||
| Price to Tangible Book Value | 6.83 | 6.97 | 2.69 | 2.76 | -110.47% |
| Enterprise Value to EBITDA | -22.35 | -13.70 | -10.52 | -7.36 | -59.16% |
| Return on Equity | 180.2% | -42.9% | -50.5% | -41.0% | -139.15% |
| Total Debt | $0.00M | $0.00M | $0.00M | $0.00M | - |
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