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| 1 Year | 5 Year | 5 Year Annualized | Since IPO | |
|---|---|---|---|---|
| UPB | -0.44% | N/A | N/A | +14% |
| S&P | +18.54% | +92.9% | +14.04% | +16% |
Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It develops verekitug, the only known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin. The company was founded in April 2021 and is headquartered in Waltham, MA.
| Q2 2025 | YOY Change | |
|---|---|---|
| Revenue | $0.94M | 0.0% |
| Gross Profit | $0.88M | 0.0% |
| Gross Margin | 93.92% | 0.0% |
| Market Cap | $590.65M | 0.0% |
| Market Cap / Employee | $11.36M | 0.0% |
| Employees | 52 | 0.0% |
| Net Income | -$39.97M | 0.0% |
| EBITDA | -$44.29M | 0.0% |
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| Q2 2025 | YOY Change | |
|---|---|---|
| Net Cash | $45.46M | 0.0% |
| Accounts Receivable | $0.94M | 0.0% |
| Inventory | 0 | 0.0% |
| Q2 2025 | YOY Change | |
|---|---|---|
| Long Term Debt | $0.85M | 0.0% |
| Short Term Debt | $0.71M | 0.0% |
| Current | YOY Change | |
|---|---|---|
| Return On Invested Capital | -129.99% | 0.0% |
| Q2 2025 | YOY Change | |
|---|---|---|
| Free Cash Flow | -$39.29M | 0.0% |
| Operating Free Cash Flow | -$39.24M | 0.0% |
| Metric | Q4 2024 | Q1 2025 | Q2 2025 | YoY Change | |
|---|---|---|---|---|---|
| Price to Book | -5.50 | 0.70 | 1.32 | - | |
| Price to Sales | 216.82 | - | |||
| Price to Tangible Book Value | -5.50 | 0.70 | 1.32 | - | |
| Enterprise Value to EBITDA | -15.71 | 3.17 | -4.48 | - | |
| Total Debt | $1.94M | $1.83M | $1.70M | $1.56M | - |
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