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Upstream Bio

(NASDAQ) UPB

Current Price$8.64
Market Cap$468.51M
Since IPO (2024)-61%
5 YearN/A
1 Year+27%
1 Month+12%

Upstream Bio Financials at a Glance

Market Cap

$468.51M

Revenue (TTM)

$2.85M

Net Income (TTM)

$143.44M

EPS (TTM)

$-2.66

P/E Ratio

-3.26

Dividend

$0.00

Beta (Volatility)

1.19 (Average)

Price

$8.64

Volume

34,510

Open

$8.94

Previous Close

$8.64

Daily Range

$8.10 - $9.10

52-Week Range

$5.14 - $33.68

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About Upstream Bio

Industry

Biotechnology

Employees

75

CEO

E. Rand Sutherland, MD

Headquarters

Waltham, MA 02451, US

UPB Financials

Key Financial Metrics (TTM)

Gross Margin

97%

Operating Margin

-56%

Net Income Margin

-50%

Return on Equity

-35%

Return on Capital

-47%

Return on Assets

-41%

Earnings Yield

-30.67%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$468.51M

Shares Outstanding

54.04M

Volume

34.51K

Short Interest

0.00%

Avg. Volume

1.30M

Financials (TTM)

Gross Profit

$2.67M

Operating Income

$160.36M

EBITDA

$160.36M

Operating Cash Flow

$133.28M

Capital Expenditure

$165.00K

Free Cash Flow

$133.28M

Cash & ST Invst.

$341.51M

Total Debt

$1.27M

Upstream Bio Performance Analysis

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name
Q4 2025YOY CHG

Revenue

$668.00K

+9.0%

Gross Profit

$611.00K

-0.3%

Gross Margin

91.47%

N/A

Market Cap

$468.51M

N/A

Market Cap/Employee

$9.01M

N/A

Employees

52

N/A

Net Income

$42.46M

-99.9%

EBITDA

$46.11M

-75.5%

Quarterly Fundamentals

Name
Q4 2025YOY CHG

Net Cash

$340.24M

-27.4%

Accounts Receivable

$668.00K

-43.4%

Inventory

$0.00

N/A

Long Term Debt

$549.00K

-51.4%

Short Term Debt

$720.00K

+2.3%

Return on Assets

-40.55%

N/A

Return on Invested Capital

-47.12%

N/A

Free Cash Flow

$30.68M

-55.0%

Operating Cash Flow

$30.63M

-56.2%

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Questions About UPB

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