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Exact Sciences (NASDAQ:EXAS)
Q2 2020 Earnings Call
Jul 30, 2020, 5:00 p.m. ET

Contents:

  • Prepared Remarks
  • Questions and Answers
  • Call Participants

Prepared Remarks:


Operator

Ladies and gentlemen, thank you for standing by. And welcome to the Exact Sciences second-quarter 2020 webcast and conference call. [Operator instructions]. I would now like to hand the conference over to your speaker today Miss Megan Jones, thank you.

Please, go ahead Ma'am.

Megan Jones

Thank you, Christina. And thank all of you for joining us for the Exact Sciences second-quarter 2020 conference call. On the call, today are Kevin Conroy, the company's chairman and CEO, and Jeff Elliott our chief financial officer. Exact Sciences issued a news release earlier this afternoon detailing our second-quarter financial results.

This news release in today's presentation are available on our website at exactsciences.com. During today's call, we will make forward-looking statements based on current expectations. Our action results may be materially different from such a statement. Reconciliations to GAAP figures are available in our earnings press release, and descriptions of the risks and uncertainties associated with Exact Sciences are included in our SEC filings, both can be accessed through our website.

It's now my pleasure to introduce the company's chairman and CEO, Kevin Conroy.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Megan. The COVID-19 crisis has highlighted the need for more convenient and accurate cancer testing options. Experts estimate that over the next decade there will be an additional 10,000 deaths from colorectal and breast cancer due to screenings that have been canceled or delayed just to the end of June. This looming crisis will continue to grow, Cologuard is an accurate at-home colon cancer screening test, we believe the COVID-19 crisis will accelerate the adoption of Cologuard by one to two years toward our 40% market share goal.

Patients and physicians are also looking for smarter, faster answers to guide their cancer treatment decisions, elevating the importance of our Precision Oncology tests. Diagnostic testing will play a larger more meaningful role in cancer care because of COVID-19. Exact Sciences is positioned to create value at every step along the way from cancer screening, to late-stage therapy selection. Our CFO, Jeff Elliott will now review our financials.

Jeff Elliott

Thanks, Kevin. Good afternoon. Let's start with our second-quarter results. Revenue was $269 million. we'll break that down by screening, Precision Oncology in COVID testing. In screening, revenue was $131million, down 34%.

COVID-19 drove a decline in test orders and a temporary negative impact on patient compliance. In April, Cologuard orders hit a low point, and then improved through June, outpacing colonoscopy growth. During that time, we estimated second-quarter colonoscopy volumes were less than one-third of their pre-COVID levels, about 5,000 new healthcare providers ordered Cologuard during the quarter, and nearly 211,000 have ordered since launched. In Precision Oncology, revenue was $103 million.

There's a normal lag between a screening mammogram and an Oncotype DX test. After a mammogram, a cancer diagnosis is confirmed and staged. Oncotype DX is ordered for patients with early stage breast cancer to help predict chemotherapy response and recurrence risk. In April the resists inefficient decline in mammograms as expected started in May, Oncotype DX has volume softens. For the third quarter, we expect total Precision Oncology revenue to decline sequentially based on mammography volume trends in recent months.

Despite this for the long-term outlook for  Oncotype DX is very strong, that's due to the robust evidence, and highly capable team supporting the test, a solid U.S. market position, and a significant international runway. COVID testing revenue was $35 million in the second quarter. Future COVID testing revenue depends on the course of the pandemic, our lab capacity, and supply availability among other factors. The second-quarter gross margin including amortization of acquired intangibles was 63%.

The non-GAAP gross margin which excludes amortization of acquired intangibles with 71%. Non-GAAP gross declines six points sequentially as COVID temporarily reduced our test volumes, and fixed-cost leverage. In April, we implemented a cost reduction program lowering second-quarter spend by over $100 million, relative to our initial plan. Since the business has recovered faster than we expected, we're reinvesting some of those savings. I'm proud of our team's ability to quickly reprioritize spending.

Sales and marketing expense was $119 million, G&A expense was $107 million, and R&D expense was $33 million. We expect the total operating expenses to increase sequentially in the third quarter as the sales team returns to the field. We restarted several clinical trials, and we invest to support our growth. other operating income included %24 million from the CARES act. As previously disclosed, net loss was $86 million.

Adjusted EBITDA was negative $5 million, and CapEx was $21 million. We ended the quarter with cash and securities of $1.2 billion. The recent rise in COVID infections has slowed the pace of recovery in our business. We are not providing guidance today because of that uncertainty. I will now turn the call back to Kevin.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks. Jeff. Currently, 46 million Americans remain unscreened for colorectal cancer. Our goal is to screen as many of them as possible with Cologuard and reach at least 40% market share of the total 106 million people colorectal cancer screening market.

The value of an at-home convenience screening test was recognized quickly by patients and providers during the COVID-19 pandemic, helping pull forward Cologuard's adoption curve. We have seen increased Cologuard use among customers who were previously infrequent users. Cologuard ordering is now near pre-COVID levels and recovered more quickly than screening colonoscopy which is down 30% to 40% year over year. This recovery occurred was significantly limited physician office access for our field sales force, a key driver of growth historically. We plan to solidify this strengthened awareness by continuing to highlight Cologuard value to providers. COVID has caused a significant backlog of screening colonoscopy with more than 1 million miss during the second quarter alone.

Gastroenterologists have the limited capacity today, and we expect they will continue prioritizing diagnostic colonoscopy and more urgent procedures even as the pandemic abates. Our team is taking action to help address this building colorectal cancer screening backlog. Key initiatives include virtual sales calls easier ordering processes, and promotion of telehealth which allows people to request Cologuard from home. To stay engaged with patients, we introduce new advertisements, a chat feature on the Cologuard website, and campaigns to support screening compliance. Cologuard convenience and accuracy coupled with our additional promotional efforts should accelerate adoption, and increase brand awareness, and loyalty. We expect this increased awareness will persist well beyond the pandemic.

Identifying the best treatment options for cancer patients quickly and accurately has grown even more important during the COVID crisis. The risk of infection has increased, and surgical procedures have been delayed. Exact Sciences helps provide these critical answers with their expanding offerings and Precision Oncology. Oncotype DX and our recent recently acquired Paradigm PCDx test support patients facing difficult treatment decisions that are further complicated by COVID-19.

Our Paradigm PCDx test is a broad panel to help guide late-stage cancer patients to the appropriate therapy. We plan to expand the launch of the tissue-based Paradigm PCDx test through our Precision Oncology team later this year. Followed by a full-year roll out next year, we believe this Oncology sales team is one of the best in diagnostics. We're also working to enhance the tissue-based test and introduce a blood-based version of the Paradigm test. Will provide more precise smarter answers across the cancer continuum with Cologuard, Oncotype DX, and Paradigm PCDx.

These tests and the breadth of our commercial lab in I.T. infrastructure uniquely positioned Exact Sciences to support early and late-stage cancer patients. We successfully adapted our automated and differentiated platform to support COVID testing. We're extremely proud of how our team of more than a thousand people from R&D, our lab, I.T., and operations collaborated under demanding conditions to develop secure FDA emergency use authorization and launch a scalable testing solution. This team rapidly raised the capacity to tens of thousands of tests per week.

We've tested more than a half-million people for COVID-19 from all 50 states. We tackle COVID testing because it was the right thing to do for our employees and our communities. This effort also helps build relationships to support other areas of the business. Demonstrates the capabilities of our team and technology, and shows the potential for future pipeline innovation. Our team's scientific capabilities and experienced positioned us to be the leader in advanced cancer diagnostics.

Cologuard's long-term outlook gives us the confidence to invest in our current product growth and our deep pipeline. We plan to expand our test offerings to our thousand-person commercial organization with sales teams and primary care, Gastroenterology, Oncology Urology, and women's health in the U.S. and internationally. Our goal is to lead the rapid shift to telehealth and convenient cancer diagnostics solutions with hundreds of millions invested in I.T. over several years including installing Epic internally to improve ease of ordering. We can maintain a deep connection with patients throughout their entire cancer journey with our customer experience engine.

We have the key pieces in place supported by a long-standing R&D collaboration with Mayo Clinic to introduce new tests for colorectal, liver, pancreatic, esophageal, and prostate cancer in the U.S. and abroad. Our pipeline of future tests is strong. This was evidence -- evident at the DDW and ASCO Scientific Conferences this year. We presented data across six cancers in different sample types including stool, tissue, and blood.

The data spanned indications from screening to recurrence monitoring. The depth and breadth of our pipeline is unmatched by our commercial is matched by our commercial capabilities. We are in a unique position to create value from our pipeline and plan to invest accordingly. Our pipeline team moved several initiatives forward during the second quarter. We made progress toward the launch of our liver cancer test for the three million Americans at high risk of developing the disease.

We presented another study at ASCO confirming the superior performance of our liver test when compared to the current guideline-recommended protein blood test. We are on track to launch our liver cancer test through our Gastroenterology sales team next year. We're also reinitiating BLUE-C, our pivotal trial to support FDA approval Cologuard 2.0, and our blood-based colorectal cancer screening test. Our primary goal with Cologuard 2.0 is to increase specificity while maintaining Cologuard high sensitivity. Based on data presented last year, we believe Cologuard r 2.0 will raise the bar even higher for aspiring market entrants. These case-controlled data showed an increase in specificity while maintaining a similar level of cancer sensitivity, and higher pre-cancer sensitivity.

These data also proved the superior performance offered by stool-based test because DNA from precancerous polyps in early stage cancer is being shed directly into the stool, but not consistently into the blood supply. We're confident in leading the colorectal cancer screening opportunity with our accurate, cost-effective approach, and a significant primary care presence we've already established four color guard. We're now happy to take your questions.

Questions & Answers:


Operator

[Operator instructions] And your first question comes from the line of Brandon Couillard with Jefferies.

Brandon Couillard -- Jefferies

Hey, thanks. Good afternoon. Jeff, I certainly understand why you'd be reluctant to offer any guidance, but you're formally for the third quarter. But can you kind of share any detail with us as far as how close our order trends progressed through the period, and then maybe some comments on where you exited or how July figure.

Jeff Elliott

Happy to assist you. This is Jeff. We've previously talked about April trends were Cologuard was down, orders were down about 60%. Remember during April that was really that the brunt of the impact from COVID when states were shutting down and implement stay-at-home measures. So that month really felt the brunt of the impact both on orders and on patient compliance. Things started to recover from the low point in April, and May was down 40% year over year. In terms of Cologuard orders, with the actions we took, and remember that convenience at-home nature of Cologuard, we returned to year-on-year growth in the month of June.

So again this is at a time when colonoscopy volumes for the quarter were down by about two thirds. And even today, colonoscopy volumes are down 30% to 40%. Cologuard returned to growth a slight growth in June. Now in July with the increased growth of COVID that we're seeing that has started to slow down some of that pace of recovery, and the month of July Cologuard orders were about a flat year on year.

Brandon Couillard -- Jefferies -- Analyst

Great. Thanks for that color. Maybe one for you Kevin. Between the two initiatives where you trying to focus on Cologuard for the colonoscopy backlog, [inaudible] telehealth, online ordering platform up and running.

Were either of those material contributions in the second quarter, how should we think about your contribution from those channels in the second half of the year. And then over time, do you think that telehealth and online platform can actually see higher compliance rates than balancing your business, recorded business.

Kevin Conroy -- Chairman and Chief Executive Officer

Well, thanks, Brandon. We're really proud of all the actions that the team has taken over the last several months with new initiatives that we think put Cologuard in an even stronger position. As we think about at some point exiting the pandemic, and all of these actions are contributing. One of them is television advertising which is -- we expect to spend about 70 million this year, and that is certainly increasing awareness. Some of that is driving them to that cologuardtest.com website where you are able to order Cologuard by answering questions making sure that you are appropriate for Cologuard.

And then a physician reviews that interacts with a potential patient. We're not breaking that out, and it's modest to start growing, and we expect over a several-year period of time for that to be impactful. Certainly, somebody who seeks out screening is more likely to complete screening, so hopefully that answers that part of the question that yes, we are seeing that there is a greater degree of compliance by people who hear the television, or see the television commercial, and then initiate testing through cologuardtest.com.

Operator

And your next question comes the line of Doug Schenkel with Cowen.

Doug Schenkel

Good afternoon, and thank you for taking my questions. So I appreciate the color. I think we all do on the Cologuard volume trend since the end of the quarter, and also in July. I guess building off of that. What about the piece of new practice additions.

How of those then pacing. What are you doing in the current environment to help drive new practice additions, given it's still a little bit different than it was in the past, and you're not able to get into to doctor's offices quite as much as you did in the past. That sounds like that's improving. And then I guess finally, how much does this metric matter. I mean it's important, but I guess what I'm getting at is that as you increase your virtual efforts, and you get more patients ordering direct arguably is this metric gonna be a little less important moving forward.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Doug. Yes, I think it will be less important. We added 5,000 new ordering physicians. So first-time users of Cologuard in the quarter which is pretty remarkable given the pandemic.

And given that our field force was largely not physically in the field during that time. That has increased to now 211,000 the total number of health healthcare providers that had ordered Cologuard. And obviously, our ability to focus on those customers is critical embedded in that question is kind of when does our field force get back to full capacity. And the first thing that we're focused on there is the safety of both our field rep,  and our customers.

And although many of our reps are back in the field, access today is much more limited than it was at the beginning of the year. And our field representatives will be able to get into the field more frequently as the pandemic abates. There are patients there on our part we're engaging with physicians through a multiple different numbers of avenues whether it is E-detailing through the VEBA platform, through the telephone, and through email and other ways to engage with our customers. So although Salesforce productivity is not what it is, we are -- Cologuard volumes are back to near pre-COVID levels, and that gives us great confidence. That as the pandemic abates, we will be able to drive our continued use of Cologuard, and go get those 45 million unscreened Americans screened.

Doug Schenkel

Ok. Thank you for that Kevin. And then just that, I guess a quick follow up. Regarding COVID-19 testing, is there -- I don't know there's probably a better way to put this, but is there a toggle between COVID testing, and Cologuard revenue volume, or will there be at some point. I guess what I'm thinking is with Cologuard volumes recovering, is there effectively a cap on what you can do in COVID just from a capacity standpoint.

And I guess a related clean up. What was the impact of COVID testing on gross margin in the quarter.

Kevin Conroy -- Chairman and Chief Executive Officer

Doug in my 11 years in Exact Science is really one of the most energizing things I've ever seen is how the team came together to develop a COVID test, submit to the FDA in a rapid period. Find the physical space, the instruments developed the test. All of the things that were required to bring up a COVID test at scale initially to support our own employees to make sure that people were safe and could deliver test results for our customers. And then to help support our community. So our goal really is to help as much as we can and then to exit this business.

And there, there is a limit to the capacity that we have. We do have the ability to deliver more test results, and we'll continue to support our communities, and we won't have to toggle between the two. Jeff, would you like to provide more color.

Jeff Elliott

Doug, on your second question on U.S. gross margin. The driver of gross margin change relative to the first quarter was really the decline in volumes, as well as some changes in mix. It really had to do with Cologuard and Precision Oncology volumes coming down lower relative to the first quarter, so that was a big driver.

When I look out to the second quarter or so to the third quarter, I do expect gross margins on a non-GAAP basis to be flat to up slightly. As improved volume leverage in the Cologuard business is largely offset or are mostly offset by the, by a decline in the Precision Oncology business. As far as capacity, we're fortunate to have always taken a long-term approach when it comes to expanding our capacity. Recall for a Cologuard in Madison, Wisconsin we now have two labs. The original lab we had built to sustain an annualized capacity of 3 million tests.

The new lab that we opened up last year could add 4 million more. Obviously right now, Cologuard volumes are not yet to that 7 million annualized. We hope to get them there as soon as possible. Over that square footage in the lab does offer.

As Kevin mentioned, room to expand our COVID testing from the 50,000 or so per week that we could do in the second quarter.

Operator

Your next question comes from the line of Brian Weinstein with William Blair.

Brian Weinstein

Hey guys, thanks for taking the questions. Just to dig in on the July comments a little bit things flattening out. Is that really just in areas with rising cases in Texas for California were not, or are you seeing a flattening as well in the Northeast, and Midwest where there's maybe less of an impact.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks for the question, Brian. Look, I don't want to get too granular here. But the exciting thing for us is that when you look at the rising of the COVID volumes now nationally, volumes are at or above where they were back in April. Yet thanks to the actions the team has taken.

Cologuard volumes are still at that pre-COVID level which is a very different scenario than we were in April. So that business is showing to be very resilient. When you dig into the numbers here there are some exciting trends here. So nationally there's, still there's still a fair number of primary care offices that are closed down by some math as you see its 20% to 30% easily that are still closed down. Yet again, Cologuard volumes are back to their pre-COVID level. When you dig in further what we are seeing is that some of the providers that previously had ordered occasionally are just really sporadic orders of Cologuard are ordering at a much higher level now.

And I think that speaks to the nature of Cologuard as an accurate at-home test. So there are some really exciting data points to dig in here that give us confidence at over time as the -- as this pandemic abates that our adoption will accelerate by a year or two.

And in terms of the July trends certainly, as we had seen a resurgence in COVID infections in states like California, and Texas, and Florida. Obviously, large populations that have an impact in the Cologuard ordering rates as fewer people go into the office to see their physician. Again, the important thing though is these underlying trends which are quite positive for Colorguard short term and long term.

Brian Weinstein

Appreciate that. Thanks for the answer there. And then on the comments that you keep making rubbing back there pretty COVID level in. You're referring better than colonoscopies even without significant access to a lot of these physician offices.

How does that change the way that you think about the investments that you make going forward in your sales force, in sales and marketing, and how you go out. Does it kick in --how should we think about the efficiency that you might be able to gain as a result of this type of stuff.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Brian. Another thing that I'm really proud of the team here is that the team reacted very, very quickly to the crisis. And as we saw volumes initially decrease the team acted very quickly to reduce expenses so that we could be in the strongest position possible coming out. As volume started to increase then the team also acted rapidly to make intelligent investments to support future growth. Jeff can provide a more color there.

Jeff Elliot -- Chief Financial Officer

The recovery we've seen in Colorguard speaks to the return on this investment. I'm confident that our reps that the actions our marketing team took are what's driving this improvement, relative to a colonoscopy, and relative to the broader landscape. So it speaks to the positive return and longer-term given the size of this market. There are 106 million Americans who are in this target market, I'm confident this investment over time will continue to pay off as it has since we launched the test.

Operator

And your next question comes from line of Derik De Bruin with Bank of America.

Derik De Bruin -- Bank of America Merrill Lynch -- Analyst

Hi, good afternoon.

Kevin Conroy -- Chairman and Chief Executive Officer

Hi, Derik.

Derik De Bruin -- Bank of America Merrill Lynch -- Analyst

Hey, hey. You know we saw some news recently that Humana with launching these test kits for all and sending out the FIT test. And I'm just wondering, do you think that could have any impact on the business. I mean, there could be some confusion between FIT test and Cologuard, and I'm just wondering if it's -- if your counter detailing against that.

Kevin Conroy -- Chairman and Chief Executive Officer

I remember Derik when going back about 10 years ago sitting down with ahead of a large primary care practice who said one of the most frustrating things is how frequently they handed out that test, and how infrequently they came back. Being handed out by a health insurance company, you can send a million out and maybe get a hundred thousand back. And then one year later that person is effectively still in the unscreened population because it's a test to be effective needs to be done every year. So one year later they still need either a Colorguard test or a colonoscopy. That's a long way of saying that these FIT, programmatic FIT programs aren't just simply -- aren't very effective, and that's one of the reasons we develop Cologuard, a more accurate test that makes the patient good on their colon cancer screening for three years.

And then it also highlights the value of the infrastructure that we've built. This incredible customer experience engine that not only delivers a Cologuard test kit but also prompts patients to return that test kit and helps them understand what they need to do as a next step. So, No. We don't expect that one program like these. These are our common programs that occur all of the time.

They're not really that -- that's not unique. What we're delivering here is value over the life of a patient's experience because we can continue to engage with them, and get them rescreened over time.

Derik De Bruin -- Bank of America Merrill Lynch -- Analyst

Great. Thank you. Just one follow up on the Precision Oncology business. Can you talk If I missed it, I apologize for U.S.

versus U.S. tech trends in that business. And also,  just a little bit more color on the Paradigm test, and how much that contributed and your expectations for revenues on that. Thank you.

Jeff Elliot -- Chief Financial Officer

Sure, Derik. This is Jeff, happy to answer that. So international COVID trends were really a couple of months ahead of the U.S. trends.

And you're seeing that play out in a similar manner in our business, whereas the U.S. Precision Oncology business stayed strong, really through the end of April, and started to decline in May. The Precision Oncology business was hurt a little bit earlier in the year. That business did perform relatively better. The international business performed better during the second quarter.

I think in large part because of the way COVID has played out. Also, the international market is relatively under-penetrated, and there's a large growth opportunity over time there. We have some positive trends there, and reimbursement increasing adoption so, the international business is nice driver overtime for that. Paradigm, not material -- really started to have that business in-house to really see its growth platform for years to come.

As Kevin talked about in his remarks, we plan to run an initial pilot through the Precision Oncology salesforce later this year with a full launch to that sales team next year. Given how large and experience that sales team is, we expect very good growth next year. However, at this point, it's not a material contributor to revenue.

Operator

And your next question comes from the line of Patrick Donnelly with Citi.

Patrick Donnelly -- Citi -- Analyst

Thanks, guys. Maybe just on the colonoscopy shift, are you able to discern new patients who are shifting over from delaying colonoscopy to taking Cologuard. Are there any metrics like increasing cologuard.com visits or online orders that can be tied back to that. I'm just wondering how you guys are trying to track.

How effective you're being in capturing that obviously, very large potential opportunity.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Patrick. The opportunity here you can really see affected by the doctors who previously infrequently ordered Colorguard and you can see that their use of Cologuard is up significantly, although you can't make that direct connection is pretty clear these are patients who they otherwise would have probably sent to colonoscopy, and now are sending to Cologuard as the testing option. There -- that is driven again without the impact of our, our field force. And over time, what we, we expect this will do.

It gives the physician a deeper experience with Cologuard. They're able to see that their patient satisfaction with the non-invasive option, and one data point that we, we recently just got, we just got a survey back of 150 healthcare providers. And 70% of them say that Cologuard will play a more important role in colorectal cancer screening in the future, and 75% of them expect Colorguard volumes to increase over the next year. So this -- that this has to be in part because of a shift from colonoscopy to Cologuard.

Patrick Donnelly -- Citi -- Analyst

Definitely encouraging. Thanks, Kevin. And then maybe just one on the Pfizer relationship. Just something we get asked about a decent amount.

How does that evolve from here. Obviously, it's tied to revenue numbers that did not anticipate COVID, so maybe just update us where that stands and your general thoughts. Thank you.

Kevin Conroy -- Chairman and Chief Executive Officer

Sure. Sure, we entered into our partnership with Pfizer not quite two years ago, and it's been an incredible partnership that has achieved most of our goals. We've added new providers, and health systems. We've increased awareness through our joint marketing campaign.

We've reached more providers more frequently. And presently, we're in discussions to adjust the Partnership for this COVID environment and optimize the incentives so that it is a partnership that continues at least through the end of the current partnership which is the end of next year. And we have time here to decide whether to continue that, build our own capacity, or some version of both. That is a decision that will be made down the road.

Operator

Your next question comes the line of Catherine Schulte with Baird.

Catherine Schulte -- Robert W. Baird -- Analyst

Guys, thanks for the questions. First, you've talked a couple of times today about COVID accelerating the adoption of Cologuard by one to two years toward your long-term market share goals. So with that in mind, I mean by what point do you think it does start to be a net positive to the Cologuard trajectory.

Jeff Elliot -- Chief Financial Officer

Thanks, Catherine. This is Jeff. I think part of what Kevin talked about before is what really gives us confidence. Is that we are seeing providers who typically hedges [Inaudible] ordered sporadically starting to order more frequently.

And that really speaks to the nature of Cologuard began the at-home convenient test, as well as the size of this market with 106 million Americans who are in the target market. 46 million of those still needing to be screened. So given that combined with the actions this team has taken, as far as bringing up a telehealth site quickly, as far as adapt into telesales, and bring in a new TV advertisement that is adjusted for the COVID environment. We're pleased with the speed at which his team moved, and we're pleased and pleasantly surprised by the pace of this recovery. I'm not going to speculate or guide to the future because of the uncertainties with COVID.

But given this increased adoption in these pockets, and these trends that we're seeing, we are confident that we will pull ahead of that adoption by at least a year or two.

Catherine Schulte -- Robert W. Baird -- Analyst

Ok, great. I know you've been putting a big focus on capturing the rescreen opportunity. Any comments on how that turned out in the quarter, and what kind of progress you've been able to make there.

Jeff Elliot -- Chief Financial Officer

Rescreens is a really important growth opportunity for us both this year, and the long term. It's already a material part of the business. This year there are over 370,000 new patients who become eligible for their three-year rescreen opportunity. And I'm excited to say that because of the actions the team has taken, we are seeing an increased capture rate of those patients.

Really, this new I.T. tools we have put in place allow us to quickly identify who is eligible, target them both directly to the patient, as well as identified to the ordering provider when a patient is due. A new feature we just rolled out this week can allow a healthcare provider to see all the patients that she has who are now eligible, and quickly verify their information and place that three-year rescreening order through the click of a button. So the team is getting better at identifying, and capturing this opportunity, and it's something that will be a material growth driver from going forward.

Operator

And your next question comes from line of Dan Brennan with UBS.

Dan Brennan -- UBS -- Analyst

Thanks for taking the questions. I was hoping to dig in on the telehealth angle. Is it possible to discuss this quarter what was the mix in orders roughly to telehealth and in-person. And how you think that mix will shift going forward over the next year or so. And Kevin knew, and Jeff, you both this has a lot of actions being taken to optimize the ability to use telehealth.

I'm just wondering how optimized are you today for telehealth. Are there any important steps that need to be taken in the next couple of quarters or year that could further possibly accelerate that adoption.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Dan. We are still very early in the adoption cycle of people choosing to get screened, self-initiated through cologuardtest.com. Clearly, the waiting is very heavily toward the normal process of a physician ordering a test. And let me remind you that the number of office visits is down appreciably, probably more than 30%.

And so for our Colorguard testing to be back at pre-COVID levels that give us excitement for the future. In terms of telehealth, this is one component of a broader strategy. So for patients to self-initiate is one part of it. Another part of it is that wherever a doctor and however, a physician is engaged in a telehealth encounter with a patient is where we want them to be able to order Colorguard electronically.

So as you know within the Epic environment there can be a virtual patient visit or a telehealth visit. And toward the end of this year, Cologuard or electronic ordering will be embedded in Epic as the next rollout, and upgrade of that back occurs across the country. So this is a multifaceted effort, and we think a very powerful one that set us up and differentiates us. And then also, it provides a unique opportunity for us to plug in our pipeline tests through that same capability. It is something that we have invested as Jeff said in his earlier comments, over $300 million in I.T.

that pay off it, or for patients and physicians is going to occur over the next one year, five years, and 10 years. And we look forward to that.

Dan Brennan -- UBS -- Analyst

Great. Thanks, Kevin. And then maybe just one on the comment about order is being back to normal. I'm just going to put that in context.

So I think by our math you had about nearly 460,000 tests, completed tests in 1Q. That was pre-COVID. Is that we're back to normal implies, like we're going to go off that at the jumping point as we look forward. Just trying to think about that comment and how we might utilize that as we think about forecasting going forward sure.

Jeff Elliot -- Chief Financial Officer

Sure, Dan. This is Jeff. Two comments today I gave. One was on the year-over-year change in orders. I mentioned in June, Cologuard orders were up slightly, and in July, they're about flat.

Keep in mind, against a base of orders that grew through the year. We've also given Lou's commentary that Colorguard orders are about back to their pre-COVID level. Now, year over year, we typically would expect growth, so I wouldn't say things are totally normalized. There's still a very big impact from COVID due to the decline in physician office visits. Things are headed in a good direction, and this is before our sales force is largely back out in the field with normal access.

And that's before some of the initiatives we've put in place like telehealth have had their full impact.

Operator

And your next question comes from the line of Dan Arias with Stifel.

Dan Arias -- Stifel Financial Corp. -- Analyst

Good afternoon, guys. Thank you. Kevin, you mentioned that you're back on track with BLUE-C. Can you just speak to which of the other studies and were in the R&D plan you're turning things back on. Just given the recovery that you mentioned versus what might still be on the shelf as a part of the cost savings plan. And for Jeff, what is the savings amount that you're targeting now that you're reinvesting back into business.

Kevin Conroy -- Chairman and Chief Executive Officer

So, a reminder that BLUE-C is for Cologuard 2.0, and a blood-based test. We had chose to pause the trial because of the significant decline in screening call in colonoscopies. And now that screening colonoscopies are starting to occur again, those sites are showing an interest in reengaging. And so BLUE-C is kicking off in the near-term, and we think we'll be back to normal enrollment by the end of this year. We're confident in the timeline that we laid out for the BLUE-C study and that which again, is for both a stool-based test and a blood-based test.

This -- our study infrastructure coupled with our lab, I.T. commercial infrastructure together allow us to launch additional studies like our studies in liver, and a slew of other pipeline tests. We can go into those at some later date. Suffice it to say that our clinical affairs team is happily reengaged then, and that is accelerating.

Jeff Elliot -- Chief Financial Officer

On the spending reduction program. I recall why we put that in place back in April, given that period of heightened uncertainty. We wanted to preserve capital and make sure that we could stay nimble during this pandemic. Well as the business recovered faster to be expected, we think it's the appropriate thing to do is to reinvest back in the business because our priority here is to make the right investments for the long term, and that means driving growth and building a solid infrastructure, we think that's a great way to drive value for the long term. In the third quarter, the big changes from the second quarter would be bringing our sales force back.

Putting the sales force back in the field and it's safe to do so. Restarting the studies that Kevin talked about. We do expect to step up in R&D, and also a higher-end to support the continued growth. When you think about the volumes we're putting through our labs now, this is very significant. These are higher volumes than we've ever done before.

When you consider the combination of COVID testing, Cologuard. So we have to hire to continue to support that growth.

Dan Arias -- Stifel Financial Corp. -- Analyst

Ok. So, but if we were basing our model math around the 400 million that you talked about. What would be the number that we should now base our model math on.

Kevin Conroy -- Chairman and Chief Executive Officer

We're not going to see that number. It will be considerably less because the business has recovered far faster than we expected. Not going to provide guidance on how much. I do expect the sequential uptick in buybacks, however.

Dan Arias -- Stifel Financial Corp. -- Analyst

Okay. And then just a follow-up question on the rescreening opportunity, and the expectations there. Do you still think that you can get half of that population. I mean I think the math you guys had talked about was reaching 70% of them, and then getting 70% compliance.

How did that sound as an assumption at this point, just given the way that things have evolved.

Kevin Conroy -- Chairman and Chief Executive Officer

Yes, Dan. Longer-term, that is the goal. Look, our goal is to get as many obviously, patients screened as possible. It will be a unique position to do that, given that we know who these patients are.

We know where they live. Which providers they see at least who they saw three years ago. We know when they're due for screenings. And today, we've tested with over 4 million patients. Over time this becomes a revenue engine, recurring revenue engine that eventually becomes over half of our revenue.

So we will get this right. I think our goal is to capture at least 50%, and hopefully more than that.

Operator

Your next question comes the line of Kevin Degeeter with Oppenheimer.

Kevin Degeeter -- Oppenheimer and Company -- Analyst

Hey, thanks for taking my question. With regards to Precision Oncology, I guess these women for Oncotype DX you have come in due to their positive screening mammography based on further diagnosis or self-examination. So I guess my question is, is the reduction, the magnitude of reduction we're seeing in screening mammography is consistent with the magnitude of reduction we're seeing in actual diagnosis for these women, which I think really is what is going to drive the Oncotype volumes.

Kevin Conroy -- Chairman and Chief Executive Officer

Thanks, Kevin. We are -- we're so excited about our Precision Oncology business, and team, and opportunity. So just to frame this Oncotype DX helps guide and answer the question in early stage breast cancer whether a patient will benefit from chemotherapy. And based on the TAILORx study, about 85% of women can avoid chemotherapy that is early stage and no negative. And yes, so for patients that are -- that self-exam and then go visit a physician, and that's how that cancer is first diagnosed.

That is keeping the business strong, coupled with now the recent uptick in screening mammographies. There has been a push in and a greater awareness that in the April timeframe. You saw a significant April, May, even June time frame, a significant decrease in the number of screening mammograms in this country, and that has certainly had a temporary impact. I think the thing to note here is that this is a large U.S. market.

About a half a billion-dollar market with 73% adoption. And right after this pandemic, what we saw was a short term and a dramatic increase in the number of Oncotype DX Breast tests. And prostate tests also saw an increase because ultimately what those tests do is to -- didn't decrease the impact in the aggressiveness of surgical treatment. And we saw more oncologists in the case of the prostate test. Urologists recommend a molecular test that helps a patient potentially avoid more aggressive treatment.

So long term, we are awfully excited about Oncotype DX and then, the PCDx test which is a test for people with metastatic cancer, and it helps guide the right targeted chemotherapy. And that is a very small business today. But with our nearly hundred person Precision Oncology, Oncology sales force, 50 person Urology sales force, this test is going to be an important part of the future. And what it does is delivers a result faster than the other test. Today in about three to four days, and that turnaround time we believe will drive adoption.

Kevin Degeeter -- Oppenheimer and Company -- Analyst

Great. Thanks for taking my question.

Operator

And your next question comes the line of Max Masucci with Canaccord Genuity.

Max Masucci -- Canaccord Genuity -- Analyst

Hi, thanks for taking the questions. So we're just starting to see a wider scale COVID-19 testing for asymptomatic individuals in addition to healthcare providers, and first responders. It's evident of the U.S. supply of COVID testing is below demand especially ahead of the traditional flu season.

So how are you thinking about the duration of your COVID-19 testing opportunity, and at that COVID-19 test processing capacity of 50,000 tests per week. I think math would suggest it use just under 60% of that capacity in Q2. So are there any barriers that whether it's people or technology that's preventing you from utilizing a higher percentage of that capacity going forward.

Kevin Conroy -- Chairman and Chief Executive Officer

We will be able to increase capacity over time. And it really speaks to the incredible platform technology that we have. We had our first telephone call with an outside group that needed testing was on March 14th, and we delivered our first COVID test by March, March 30th. Capacity has scaled up ever since then, and we expected to exceed 50,000 tests per week. The truth is though this is not a business that we hope to be in the long term.

We want to do our part to help our community, and our state, and our country, and all the areas that we do business. And what it really shows is the underlying value of the team, and the platform, and the science that we're able to deliver. As we think about a pipeline that includes liver cancer testing, and pancreatic cancer, esophageal cancer, you should know that we have the ability to deliver on that from an infrastructure scientific R&D regulatory capacity. That's the take-home here.

Max Masucci -- Canaccord Genuity -- Analyst

Great. And then lots of moving parts this quarter. What traction are you seeing in the age of 45 to 49 age group for Cologuard ordering. Clinicians' willingness to order for this age group, and just where you stand any conversations you may continue to engage in with commercial payers.

Jeff Elliot -- Chief Financial Officer

Hi, Max. This is Jeff. Some 45 to 49 is an exciting opportunity. There are almost 20 million Americans who are in that target market, so it is a significant increase to the addressable opportunity. We have seen that tick up as a percentage of total Cologuard orders.

And for me, that's no surprise considering the Cologuard fits very well into the busy 45 to 49 year old's lifestyle. And the clinical evidence there is very strong. Over the past 20 years, we've seen a 50% increase in the incidence and mortality rate in that age group. So we think clinically there's a strong reason to, to adopt Cologuard in that age group. Reimbursement continues to improve for that age group.

I think the next big leg of growth, we expect is, is through greater reimbursement. That likely hinges on a guideline inclusion over the team continue to work on and driving the reimbursement higher. Given the strong value proposition for Cologuard in that age group.

Operator

Your next question comes the line of Luke Sergott with Evercore ISI.

Luke Sergott -- Evercore ISI -- Analyst

Hey, guys. Thanks for taking the question. Just a quick one here on the COVID testing on the logistics behind it. So I realize it's a different way of the test getting to you guys than your typical Cologuard or Oncotype.

Any chance that these new channels are getting the COVID testing to provide an opportunity to access new patients for a Cologuard or Oncotype that previously wouldn't have been able to access legacy channels. More so in the Cologuard obviously, than the Oncotype.

Kevin Conroy -- Chairman and Chief Executive Officer

That's been one of the great benefits of COVID testing, is that we have deepened, and strengthened our relationships with health systems that will help both Cologuard and Oncotype DX over time. We've strengthened our relationship with Epic, and we've had to set up well over a dozen interfaces between healthcare providers and our Exact lab that allowed for electronic ordering, and that will have benefits for Cologuard over time. Again, probably the largest benefit has been in showing ourselves, and our scientists, and our laboratorians, and all the teams that came together to launch a new test in a matter of weeks. And so I think people are chomping at the bit to be able to launch the next test, and over time, I think in the next five years you'll see an incredible amount of productivity in terms of new tests that are launched through this infrastructure. And that's the most important takeaway of COVID testing is our ability to help in the health system, the ecosystem in the healthcare ecosystem going forward.

Luke Sergott -- Evercore ISI -- Analyst

Ok, great. Thanks. And then I guess the last one here. Are you seeing a change in the lag between the order rate and the actual test succession.

And then you change in compliance rates. I don't know if I caught that earlier.

Jeff Elliot -- Chief Financial Officer

Luke, see the Cologuard compliance rate in the quarter was about 66%. Remember this is on a length basis. Looking back to my 18 months. That's a typical way we report it.

As far as the turnaround time. I think your question was down in order to complete the test. That was negatively impacted during the March, April timeframe, really the early days of COVID. Since then, things have largely recovered. Over time, our goal is to get that compliance rate back above 70%, and I'm confident we'll be able to do that.

Operator

And your last question comes your line of Bruce Jackson with The Benchmark.

BruceJackson -- The Benchmark Company -- Analyst

Hi. Thank you for taking my question. I wanted to circle back to the electronic ordering. Can you remind us what percentage of doctors order Cologuard electronically right now. And are you thinking about becoming integrated with any of the other electronic healthcare systems.

Jeff Elliot -- Chief Financial Officer

Bruce, this Jeff. Today, about 35% of Cologuard orders are submitted electronically. When a provider orders electronically issue orders at over a 50% higher rate than ordering via fax, It's because it's an easier ordering process. It's an easier process for us to return that result back. And it should cost us less money each time we do it because the data come in clean.

So we're looking forward to the Epic conversion that Kevin mentioned later. We are integrated today with some other cloud-based electronic health systems like Athenahealth cloud-based. We've been integrated with that one early on, and over time, we will integrate with all the systems. Cologuard is too big and too important for the product, we will make sure we integrate with all of them. So it will take time.

On the Precision Oncology side, the electronic ordering rate is significantly higher. So that shows there is a path forward. And one of the benefits of COVID testing that Kevin mentioned is deepening our relationships with health systems and providers. For COVID testing, the electronic ordering rate from the start has been very high. Today, as well north of 70% of electronic ordering.

So there are other benefits of COVID testing and that is one that we think will help Cologuard ordering electronic or in rate go higher over time.

BruceJackson -- The Benchmark Company -- Analyst

All right. That's great. Thank you, very much.

Jeff Elliot -- Chief Financial Officer -- Analyst

You're welcome.

Operator

I will now turn it back over to our presenters for any closing remarks.

Kevin Conroy -- Chairman and Chief Executive Officer

Thank you for joining us to review our second-quarter results. And thanks too, especially to all of our employees for their unwavering commitment to our mission. The way this team reacted in the face of incredible challenges due to the COVID crisis,  and a quicker than expected Cologuard recovery gives us great confidence in the path forward. We believe we are well-positioned to reach 40% of the colorectal cancer screening market with Cologuard.

Sooner, continue to grow our Precision Oncology offering, and use our deep pipeline and infrastructure to bring many more tests to patients across the cancer continuum. Thank you.

Operator

[Operator signoff]

Duration: 61 minutes

Call participants:

Megan Jones

Kevin Conroy -- Chairman and Chief Executive Officer

Jeff Elliott

Brandon Couillard -- Jefferies

Doug Schenkel

Brian Weinstein

Jeff Elliot -- Chief Financial Officer

Derik De Bruin -- Bank of America Merrill Lynch -- Analyst

Patrick Donnelly -- Citi -- Analyst

PatrickDonnelly -- Citi -- Analyst

Catherine Schulte -- Robert W. Baird -- Analyst

Dan Brennan -- UBS -- Analyst

DanBrennan -- UBS -- Analyst

Dan Arias -- Stifel Financial Corp. -- Analyst

Kevin Degeeter -- Oppenheimer and Company -- Analyst

KevinDegeeter -- Oppenheimer and Company -- Analyst

Max Masucci -- Canaccord Genuity -- Analyst

Luke Sergott -- Evercore ISI -- Analyst

BruceJackson -- The Benchmark Company -- Analyst

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