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Karyopharm Therapeutics inc (NASDAQ:KPTI)
Q3 2021 Earnings Call
Nov 3, 2021, 8:30 a.m. ET

Contents:

  • Prepared Remarks
  • Questions and Answers
  • Call Participants

Prepared Remarks:

Operator

Good morning. My name is Claudia Gunter, and I will be the conference operator today. At this time, I would like to welcome everyone to the Karyopharm Therapeutics Third Quarter 2021 financial results conference call. [Operator Instructions]. I would now like to turn the call over to Jason Finkelstein of Argot Partners.

Jason Finkelstein -- Senior Vice President

Thank you, Claudia. Thank you all for joining us on today's conference call to discuss Karyopharm's Third Quarter 2021 Financial results and business update. Today, I'm joined by Mr. Richard Paulson, President and Chief Executive Officer; Ms. Sohanya Cheng, Senior Vice President, Sales and Commercial Operations; Dr. Jatin Shah, Chief Medical Officer; Mr. Mike Mason, Chief Financial Officer; Mr. Stephen Mitchener, Chief Business Officer and Dr. Sharon Shacham, Chief Scientific Officer.

During today's call, as outlined on Slide two, Richard will provide some introductory remarks, Sohanya will provide an update on our XPOVIO commercial progress, Jatin will highlight recent pipeline advancements and then Mike will discuss the third quarter financial results highlights and guidance. We will conclude with some thoughts from Richard on upcoming milestones, and then we'll move to the Q&A portion of the call. Earlier this morning, we issued a press release detailing Karyopharm's results for the third quarter of 2021. This release, along with a slide presentation that we plan to reference during today's call are available on our website at karyopharm.com. Before we begin our formal comments, I'll remind you that various remarks we'll make today constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995, as outlined on Slide three.

These include statements about our future expectations, clinical developments and regulatory matters and time lines, the potential success of our products and product candidates, including our expectations relating to the commercialization of XPOVIO and NEXPOVIO, financial projections and our plans and prospects. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in the Risk Factors section of our most recent quarterly report on Form 10-Q, which is on file with the SEC and in other filings that we may make with the SEC in the future.

Any forward-looking statements represent our views as of today only. While we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so even if our views change. Therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today. I will now turn the call over to Richard Paulson. Please turn to Slide four.

Richard Paulson -- President, Chief Executive Officer & Director

Thank you, Jason, and good morning, everyone. Now please turn to Slide five. After joining as President and CEO in May and now having been in this position for a full fiscal quarter Ive valued the opportunity to meet and speak to many of our shareholders, customers and investigators. From our insightful conversations, I've enjoyed the enthusiasm and the commitment to our science. With the ability to positively impact patients and work across many different types of cancers, I look forward to continuing these interactions in the future as our future outlook for Karyopharm is rooted in three key fundamentals.

First is our execution XPOVIO's launch. Currently, XPOVIO is approved in three indications in the U.S. in multiple myeloma and diffuse large B-cell lymphoma. We have a tremendous opportunity in front of us to continue expanding XPOVIO's breadth and depth through continued head down execution in the approved indications and advancement of key late-stage myeloma studies. We delivered strong commercial results in the third quarter with a significant increase in net product revenues compared to the second quarter of 2021, driven by an acceleration in demand growth for XPOVIO. XPOVIO continues to move into earlier lines of therapy in multi myeloma as a new effective modality that can become the standard of care in second-line plus, which Sohanya will discuss later in the call. In parallel, we will continue to build our foundation globally.

We are anticipating that the European Medicine Agency's committee for medicinal products for human use, will complete the review of our NEXPOVIO marketing application as a second line plus treatment for multi myeloma, which is expected during the first half of 2022. The second is our pipeline. As we advance our pipeline, we are actively working to prioritize our clinical development plan in hematological malignancies and solid tumor indications with the highest on that need, probability of success and attractive market opportunities. This includes our Phase III SIENDO study evaluating Selinexor and endometrial cancer, where there are no approved treatments for maintenance therapy following chemotherapy in any line of treatment. Top line results for this study are expected by the end of this year or early next year, and if positive, will further reinforce the therapeutic potential of Selinexor in solid tumor indications. We are also advancing targeted late-stage clinical studies across multiple hematological and solid tumor indications that Jason will review later on our call, and we look forward to hosting a virtual Investor Day on Wednesday, December eight to present further details on our commercial and pipeline priorities.

To support our focused growth plan, we are well capitalized to fund our operations with a cash runway into the middle of 2023. Third is our people who foster scientific creativity, pioneering technologies and are dedicated to delivering XPOVIO to patients. We support a culture of innovation, courage, urgency, resilient and energy captured in our IQ values with our employees and our collaborators. I'd like to sincerely thank our team who are focused on helping patients in need and delivering for shareholders. As we turn now to Slide six, I would like to turn the call over to Sohanya Cheng, our Senior Vice President of Sales and Commercial operations for her review of the commercial results for the quarter. Sohanya?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Thank you, Richard, and good morning, everyone. We have accelerated growth in the third quarter and continue to make strong progress across key indicators since our second line plus launch at the beginning of this year. Please now turn to Slide seven. Total XPOVIO net product sales for the quarter were $26.7 million, a 32% increase quarter-over-quarter and a 25% increase year-over-year. These increases were driven by strong execution, with over 9,000 prescriptions filled as of the end of the third quarter.

We continue to see a positive shift from the penta-refractory setting toward earlier lines with the most rapid growth this year in the third line as we continue to focus our messaging on the white space in myeloma between second and fourth line, where using a new class of therapy could be vital for the success of patients' outcomes. We are expanding in breadth and depth of use of XPOVIO, with strong growth in the community setting. We continue to add more accounts every quarter and increase penetration at top myeloma accounts. In addition, our intent to prescribe data continues to show sustained improvement in the efficacy and safety perception of the product and growing confidence in utilization in earlier lines as physicians have an increasingly positive experience with the lower dose once-weekly XPOVIO based triplet regimen.

While patient visits and field activity improved in the third quarter, they have not returned to pre-COVID levels. We will continue to monitor any further COVID impact and remain focused on strong execution and positioning XPOVIO as a standard of care in second-line plus. With the foundation we are laying now and with a rapidly advancing myeloma pipeline, we hope to continue to drive a steady growth in the near, mid and long term. If you will now advance to Slide eight, I will turn the call to Jatin to highlight our clinical development efforts to further build our position in multiple myeloma, other hematological and solid tumor indications. Jatin?

Jatin Shah -- Executive Vice President & Chief Medical Officer

Thank you, Sohanya. If you'll now please turn to Slide nine. I'd first like to touch on our key regulatory advancements. As you know, our marketing authorization application in the EU has been validated and is currently under review by the CHMP and as Richard mentioned earlier, we expect this review to be complete during the first half of 2022. We are seeing progress with bringing Selinexor to patients in need across the globe by our ex-U.S. partners, including a new drug submission that was recently submitted by Forest Therapeutics and accepted for review by Health Canada. In addition, we saw the approval of Selinexor for the treatment of patients with multiple myeloma and DLBCL in South Korea and several new drug applications in multiple Asia Pacific markets, including China, Hong Kong, Australia, Singapore and Taiwan, all of our partner entity.

Turning now to Slide 10 for clinical stage programs. We are advancing our pipeline across multiple oncologic indications with a high unmet need. This is a snapshot of our clinical pipeline, including key new clinical studies that were recently initiated, including the MF 34 study evaluating Selinexor in combination with ruxolitinib in treatment naive myelofibrosis. The MEL 33 study evaluating Selinexor in combination with pembrolizumab in patients with locally advanced or metastatic melanoma; and finally, the 801 study evaluating eltanexor in myelodysplastic syndromes. We'll provide more details on these studies in just a moment. We're actively prioritizing our pipeline and look forward to communicating our refined corporate vision and objectives at our virtual Investor Day that's planned for December 8, 2021.

At this time, the Phase III SIENDO study represents the next major milestone and we remain highly encouraged by the opportunity for Selinexor in patients with endometrial cancer in the maintenance study, which is outlined on Slide 11. Now endometrial cancer is the most common gynecological cancer in the U.S. with over 66,000 new cases in 2021. While most women are diagnosed with early stage disease and with a good prognosis after surgery alone, approximately 14,000 patients each year will present with advanced or metastatic disease. These patients are typically treated with chemotherapy for four to six cycles. And as there are no therapies approved for maintenance, after chemotherapy, patients are followed with close observation in a watch and wait approach. Unfortunately, the treatment is not curative, and there's a short remission time, typically four to six months before the disease returns.

And when their disease progresses, these patients are typically treated with additional chemotherapy immunotherapy or targeted agents. Maintenance therapy has been a very effective strategy in multiple diseases to extend the time and remission. Concept of maintenance therapy has been well-established in gynecological malignancies with PARP inhibitors in ovarian cancer, yet there are no proved maintenance therapies for patients with endometrial cancer post chemotherapy. To put the potential opportunity in endometrial cancer in perspective, 14,000 patients each year are treated with chemotherapy and could potentially benefit from maintenance therapy with this number estimated to grow in the future.

Looking at Slide 12. In our initial Phase II SIGN study, we look at single agent Selinexor in patients with chemotherapy refractory disease with a high disease burden that's growing and not in remission. In this population, with currently available treatments, most patients either do not respond or have a transient stable disease for less than eight weeks. In this patient population, we demonstrated the activity of single-agent Selinexor, with nearly 1/3 of patients in this refractory setting with disease control, which is defined as those with a complete response, partial response or stable disease for at least three months. In this third-line setting with chemotherapy refractory disease, Selinexor demonstrated a median duration of disease control of 6.3 months. This data supports the evaluation of Selinexor in earlier lines of therapy.

To be clear, in contrast to Sign, in the SIENDO study evaluates Selinexor in the first-line setting in chemotherapy sensitive setting, as you see on Slide 13. The Phase III study regarding the role of once-weekly low dose Selinexor in patients with endometrial cancer as maintenance therapy post chemotherapy. The SIENDO study is enrolling approximately 248 patients, randomized 2:1 to receive either 80 milligrams of Selinexor once-weekly or placebo. Eligible patients include those who have stage IV or recurrent disease, we have completed the course of taxane-platinum combination chemotherapy and achieved either a partial or complete response. The primary endpoint of the trials and improvement in progression-free survival or PFS, is defined from the time of randomization until death or disease progresses.

In November of 2020, we announced the trial that passed its planned interim futility analysis and so the study has continued as planned. Recruitment is on track and we expect the top line data, which is event-driven by the end of this year or early next year. Turning now to Slide 14. We recently commenced dosing an expanded Phase II study, evaluating eltanexor, our second novel oral sign compound in patients with MDS. MDS occurs when the hematopoietic stem cells within the marrow become abnormal and create immature blood cells that are not able to function properly, which leads to significantly low blood counts.

It is estimated that approximately 15,000 new cases of MDS occur in the U.S. annually with a prevalence of approximately 60,000 in the U.S. through an aging population and an improving awareness of the disease, this incidence is expected to increase. Hypomethylating agents or HMAs, are the current standard of care for patients with newly diagnosed high risk MDS. However, only 50% of patients respond and these responses typically last less than two years. Unfortunately, HMA therapy is not curative and all patients ultimately develop disease that's refractory to HMA therapy.

There are no class of drugs approved in HMA refractory disease and the prognosis in HMA refractory disease is poor with a median overall survival of four to six months. There are no agents currently approved for HMA refractory disease and the need for novel efficacious agents is critical. If you turn to Slide 15, you will see in our Phase I study, single agent eltanexor, showed clear single-agent activity in patients with high-risk relapsed MDS that was refractory to HMAs. In that study, eltanexor demonstrated a 53% overall response rate and a median overall survival of 9.9 months, doubling historical controls of four to six months. At the recommended Phase two dose of 10 milligrams, eltanexor monotherapy was well tolerated with a low incidence and grade of gastrointestinal events.

Exacerbation of cytopenias occurred in 20% to 40% of patients. Based on a promising signal observed in the Phase I study, we're pleased to have recently initiated dosing in the Phase II expansion, the design of which you can see on Slide 16. Finally, I'd like to highlight our emerging program in myelofibrosis. Turning now to Slide 17. In the U.S., it's estimated that approximately 5,000 cases of myelofibrosis occur annually with a prevalence of 16,000 to 18,500 in the U.S. Currently, in myelofibrosis there's only a single class of drugs, JAK inhibitors, which are approved and used commonly in the first line. Unfortunately, ruxolitinib is not curative, and the disease often progresses within four years for primary responders.

There are no other class of drugs approved and relapsed myelofibrosis and the need for novel therapeutics is critical. Turning now to Slide 18. In preclinical studies, inhibition of nuclear cytoplasts transport by Selinexor or eltanexor, reduced survival of cells expressing JAK in both ruxolitinib sensitive and resistant cells. These data-led to an investigator-sponsored Phase II study evaluating once-weekly low dose selinexor in patients with ruxolitinib resistant myelofibrosis. The data from this investigator-sponsored Phase II study has been submitted to ASH 2021 for potential presentations during the fourth quarter.

On Slide 19, you can see the study designed for a new company-sponsored randomized multi-center Phase II study, which is expected to start also during the fourth quarter. We look forward to updating you on the progress of this and all of our important studies at our virtual Investor Day. With that, I'll now advance to Slide 20 and turn the call over to Mike Mason to review the quarterly financials. Mike?

Mike Mason -- Senior Vice President, Chief Financial Officer & Treasurer

Thank you, Jatin. Since we issued a press release earlier today with the full financial results, I will just focus on the highlights which begin on Slide 21. Total revenue for the third quarter of 2021 was $37.7 million compared to $21.3 million for the third quarter of 2020. The net product revenue for the third quarter of 2021 was $26.7 million compared to $21.3 million for the third quarter of 2020 from U.S. commercial sales of XPOVIO. The estimated growth to net discount for XPOVIO in the third quarter was 15%, which was on the lower end of our expected range of 15% to 20%, and we continue to expect to be in that 15% to 20% range for the full year 2021.

We recognized $11 million of license and other revenue for the three months ended September 30, 2021, including $9.8 million in milestone payments from antigene following the July 2021 approval of selinexor for the treatment of patients with multiple myeloma and DLBCL in South Korea and $1.2 million of revenue associated with named patient programs. R&D expenses for the third quarter of 2021 were $45.8 million compared to $37 million for the third quarter of 2020. The increase in R&D expenses, as previously stated on our Q2 call was primarily attributable to the $7.4 million asset purchase of new medicines in the third quarter of 2021.

The SG&A expenses for the third quarter of 2021 were $35.1 million compared to $31 million for the third quarter of 2020. The increase in SG&A expenses compared to the third quarter of 2020 due primarily to an increase in personnel costs primarily related to an increase in headcount and compensation costs. Cash, cash equivalents, restricted cash and investments. As of September 30, 2021, totaled $209.3 million compared to $276.7 million as of December 31, 2020. The based on our current operating plans, we expect our non-GAAP R&D and SG&A expenses, which excludes stock-based compensation expense for the full year 2021 to be in the range of $270 million to $290 million.

We expect that our existing cash, cash equivalents and investments as well as the revenue we expect to generate from XPOVIO product sales and other license revenues will be sufficient to fund our planned operations into the middle of 2023. I'll now flip to Slide 22 and turn the call over to Richard for some final thoughts. Richard?

Richard Paulson -- President, Chief Executive Officer & Director

Thank you, Mike. We are building off a very strong first nine months of the year. And as we move into the fourth quarter and beyond, there are a number of key near-term catalysts and milestones for us to deliver on as we continue to strengthen our organization and deliver for patients with high unmet needs, as outlined on Slide 23. In multiple myeloma, our focus remains on the continued enhancement and strong execution for our commercial organization to secure increased XPOVIO sales in the second line plus treatment setting.

We are awaiting the completion of the review of the MAA package in the EU based on the data from the Phase III BOSTON study. We plan to initiate our Phase III study of XPD in multiple myeloma later this year an all-oral combination that would allow us to further build in the multiple myeloma landscape. From our solid tumor programs, we expect top line data from the Phase III SIENDO study in endometrial cancer later this year or early next year, a market opportunity where there are no approved drugs in the maintenance setting following chemotherapy in any line of treatment. We have additional selinexor data in various hematological indications submitted to ASH 2021, and we look forward to announcing our selected abstracts tomorrow, Thursday, November 4.

Lastly, we plan to host a virtual Investor Day on December eight to review our strategic imperatives and pipeline priorities to support our continued evolution as a company. To close, we're excited to continue delivering for patients who are fighting cancer across the world. I look forward to updating the investment community on our continued progress in the months and quarters ahead. And with that, I would now like to ask the operator to open the call up to the question-and-answer portion of today's call. Operator?.

Questions and Answers:

Operator

[Operator Instructions]. The first question comes from Maury Raycroft from Jeffries.

Maury Raycroft -- Jefferies -- Analyst

Congrats on the update today, thanks for taking my question. So I was just wondering if you can talk more about what you're seeing in the third-line setting. What are the most common treatments that patients are coming off of before getting XPOVIO? And in that third-line setting, is it the BOSTON regimen that's being used? Or what else can you say about the combo preferences?

Richard Paulson -- President, Chief Executive Officer & Director

Sure. Thanks, Maury. I'll turn to Sohanya to answer that.

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. Thanks, Richard. As you heard earlier, we are seeing an acceleration in the shift from later lines into earlier lines. And our syndicated data indicate the strongest growth this year is in the third-line setting. In terms of patient proportions, we see an approaching 50-50 split between patients in the second to fourth line and patients in the fifth line plus setting. In terms of the overall treatment paradigm, most patients are treated with an IMID, a proteasome inhibitor or an anti-CD38 in the first or second line. In the later lines, we see several new competitors or classes in the mix.

We believe we are strongly positioned in that middle section of second to fourth line, where a class switch to an XPOVIO based regimen could be vital for the success of the patient. We are also highly effective in subgroups of patient types, such as high-risk elderly and renal dysfunction. As we continue to look into the future, we expect to see the sustained shift in the line of therapy from the later lines from the original penta-refractory indications to earlier lines in line with our BOSTON data, which launched at the beginning of this year.

Richard Paulson -- President, Chief Executive Officer & Director

Does that address your question, Maury?

Maury Raycroft -- Jefferies -- Analyst

Yes, that's helpful. And maybe one quick follow-up. In the last couple of quarters, you guys have reported metrics on refill rate. I'm not seeing it in this update. Just wondering if you can comment a little bit on what you're seeing with the result. Great.

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes, absolutely, Maury. So we are still in the early stages of the launch of the second line plus indication since the beginning of this year. And this data is still maturing. We do have preliminary data that shows that more patients are staying on therapy longer. And this is driven by two factors, the shift into earlier lines as well as better side effect management. As we evolve into earlier lines, we expect to see the duration increase driven by that shift into earlier lines and in line with our targeting positioning. However, we cannot definitively guide to a specific duration number at this time since we're in a dynamic phase of our transition into earlier lines of use and in an early stage of the launch. So we need to let that data mature.

Maury Raycroft -- Jefferies -- Analyst

Okay, OK. Makes sense, congrats again and thanks for taking my question.

Operator

The next question comes from Peter Lawson from Barclays.

Peter Lawson -- Barclays -- Analyst

[Indecipherable]

Operator

Peter sorry to interrupt. If you don't mind just speaking up a bit because we cannot hear you your line is quite low.

Peter Lawson -- Barclays -- Analyst

Yes, congratulations on the quarter. And the drivers in 3Q, kind of what will continue into 4Q? How should we think about that? And the kind of what's left to accelerate revenue growth in 4Q and into 2022? Thank you.

Richard Paulson -- President, Chief Executive Officer & Director

Thanks, Peter. We'll turn to Sohanya on that.

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. Thanks for the question, Peter. So we saw significant demand growth this quarter, contributing to 32% to quarter-over-quarter revenue growth, and we feel very confident in our sustained growth. This was driven by strong execution and the new positioning we introduced in the second quarter in that white space of second to fourth line. Now in terms of drivers, there's three key indicators. Number one is the acceleration of that shift into earlier lines. And as I mentioned, our syndicated data is indicating that strongest growth this year in the third line as well as the shift from the XPOVIO based doublet regimen to once-weekly triplet based regimen in line with our BOSTON indication, and we expect to continue to see a shift in that line of therapy.

The second driver is the expansion in the breadth and depth of use of XPOVIO. We're adding more accounts every quarter, and we're increasing our penetration at the top myeloma accounts. The most significant growth that we saw was in the community setting, and we expect to continue to see that in the future as well. Lastly, in terms of the qualitative market research as well as customer feedback that we are getting, we see a sustained improvement in the overall product perception and a growing confidence among physicians in managing this product with our new lower dose once-weekly XPOVIO based triplet regimen.

So as I mentioned, we are still in the early stages of the second line plus launch, and we won't be giving sequential growth guidance, but we remain confident in our ongoing efforts to drive increasing use in earlier lines, growth position, confidence in XPOVIO and remain focused on very strong execution.

Peter Lawson -- Barclays -- Analyst

Great. Thank you. Just with a one timers in the quarter that we should be thinking about as we kind of grow revenues off of Q3?

Jason Finkelstein -- Senior Vice President

No, no one time impacts in the quarter.

Peter Lawson -- Barclays -- Analyst

Perfect. Thank so much. Thanks for taking the questions.

Operator

The next question comes from David Lebowitz from Morgan Stanley.

David Lebowitz -- Morgan Stanley -- Analyst

Thank you very much for taking my question. Given that there's so much shift in the treatment paradigm for multiple myeloma, where does the Velcade combination actually end up, I guess, being most predominant? Will be in the second line or the third line, given that where Darzalex has been increasing its use. And beyond that, was there any inventory shifts or anything in the quarter on the wholesaler side?

Richard Paulson -- President, Chief Executive Officer & Director

Yes. Maybe I'll just start with Mike to talk on the inventory side, and then I can turn to Sohanya to talk about utilization in that second to fourth line, David.

Mike Mason -- Senior Vice President, Chief Financial Officer & Treasurer

Sure. On the inventory side, it was a minor drawdown in inventory in the quarter. But as you remember from last quarter, we had about a $2 million shift. So it was a minor impact on the quarter. So we expect inventory to not have a meaningful impact on quarterly revenue going forward.

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. And as far as your treatment paradigm question, most patients, as you mentioned, are treated with an anti-CD38 or IMID or a PI in the first and second line. So following that and prior to the later line therapies, there is that significant unmet need where we are seeing the most rapid growth in both second and third-line for XPOVIO. Now our sales and marketing teams will of course only promote to the FDA-approved XPOVIO combination with bortezomib and dexamethasone, and we're continuing to see a rise in that triplet regimen in the third line and second-line setting. However, NCCN also has other regimens on board, XPOVIO in combination with pomalidomide and dexamethasone and XPOVIO in combination with daratumumab, and dexamethasone. And as I mentioned, we only promote to the XPOVIO combination in our FDA label. But we are seeing that positive shift from the doublet late-line setting toward that triplet setting in earlier lines, in line with our BOSTON indication.

Richard Paulson -- President, Chief Executive Officer & Director

And Jade, maybe just want to expand on that from your perspective?

Jason Finkelstein -- Senior Vice President

Yes, absolutely. I mean I think from the treatment paradigm perspective, we're seeing increase using of CD38 based therapy in that first and second line, as Sohanya mentioned. And so these patients are either getting an IMID plus the CD38 or a PI plus the CD38 as they progress on that, those therapies, then coming into third line. It starts really leveraging two principles that we're very comfortable with in myeloma, which is class switching. And so if they're on an IMID-based therapy, then switching to a PI based therapy such as Velcade becomes attractive. It is based on kind of sound reasoning for the last 20 years of class switching. So I think that there's a strong degree of comfort around Velcade based therapies in the community for many years. And so as Sohanya mentioned, there's multiple options now for XPOVIO based therapy for what the physicians want to do, and they have that optionality.

David Lebowitz -- Morgan Stanley -- Analyst

Thank you for that, and shifting over to eltanexor. Has selinexor been studied previously in MDS, if you could remind us and what was the experience? And how would eltanexor differ?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. Great question. So selinexor has been evaluated in MDS previously. There was a Phase I study, Phase I/II study done with Dr. Klimig out of Memorial Sloan Kettering. there they showed a proof-of-concept with activity with single-agent selinexor in that setting and relapsed MDS with a response rate greater than 30%. So there is that proof-of-concept now with both selinexor and eltanexor in MDS that provides that body of data and the confidence around signed compounds in MDS.

David Lebowitz -- Morgan Stanley -- Analyst

And the decision, I guess, to move with eltanexor in this population was it based on the tolerability?

Richard Paulson -- President, Chief Executive Officer & Director

Yes. So as we look at the totality of the data, there are differences with eltanexor, where with the ability to give low dose continuous eltanexor for five days in a row. We saw better activity in our early data with eltanexor. When you look at the totality of data with selinexor and eltanexor, where we made a decision to really develop eltanexor in MDS and the myeloma malignancies.

David Lebowitz -- Morgan Stanley -- Analyst

Got it. Thank you very much for taking my questions. Congrats on the quarter.

Operator

The next question comes from Brian Abrams from RBC Capital Markets.

Lennette -- RBC Capital Markets -- Analyst

This is Lennette on for Brian, thanks for taking our questions. I actually wanted to stay with eltanexor for a moment. So I'm curious what you guys are thinking about in terms of the regulatory and clinical bar and MDS for eltanexor, kind of what you're hoping to see and how you're seeing this landscape evolve right now? I mean, is there a potential for this to be a registrational trial, given the unmet need? I'm just curious on your thoughts there. Thanks.

Mike Mason -- Senior Vice President, Chief Financial Officer & Treasurer

Yes, great question. And so as, this field of MDS is rapidly evolving. But what's clear is this, right, HMA therapies are the standard of care in first line. All the other drugs in development and there are no other drugs other than HMA -- HMAs right now they are approved in MDS. Number two, when you look at all the other kind of study drugs that are being evaluated in MDS, those are all being evaluated in newly diagnosed MDS. So the field is actually not evolving in the relapsed/refractory space.

There are no drugs approved in the relapsed/refractory space, and there's really limited to no therapies being developed in that relapse space. So we look at the other -- most of the other studies, they're all in newly diagnosed based. So that really leaves a very clear unmet need and an opportunity in the relapse space, and that's where we see a clear signal with eltanexor in that setting. And so as you look at the field, in the relapsed/refractory space, the field is not evolving as quickly as you would anticipate.

Richard Paulson -- President, Chief Executive Officer & Director

And then I think maybe Jade, just to expand on, if you look at the evolution of the data and with the study, how we would look at positively engaging with regards to the FDA based on the outcomes I think our data continues to hold up. It's obviously a big impact for patients and positive for them.

Jason Finkelstein -- Senior Vice President

Yes, absolutely, there's a clear unmet medical nether. And when you look at the response rates that we see with eltanexor, I think if we continue to see response rates in this range, then these would be positive. And we'll have discussions with the agency at that point in time.

Lennette -- RBC Capital Markets -- Analyst

Got it, thank you.

Operator

The next question comes from Eric Joseph from JP Morgan.

Anna -- JPMorgan -- Analyst

This is Anna on for Eric, thanks for taking the questions. Just a few from us. So first, looking more closely at the new patient starts, are you able to see if there's any efficient stickiness, meaning, like are you seeing any formally prescribing physicians now prescribing exposure for their patients in earlier lines? Or are the majority of those underlying scripts coming from new prescribers?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. Thanks for the question. We're seeing a continued growth in new patient starts, and that's driven by an expansion in both the breadth and depth of use. So there's new prescribers coming onboard and trying XPOVIO for the first time as well as we're growing in depth. So there's prescribers that had used XPOVIO in the original later line indications, and we're now seeing them growing in confidence in using it in earlier lines. So we're seeing that shift into second and third line.

Richard Paulson -- President, Chief Executive Officer & Director

Does that address your question, Anna?

Anna -- JPMorgan -- Analyst

Yes. That addresses it. And then moving toward just your recently initiated Phase II trial in combination of pembrolizumab for melanoma. Just where and how do you see this combination sitting into the indication in the current treatment.

Richard Paulson -- President, Chief Executive Officer & Director

I'll turn it to Jatin on that.

Jatin Shah -- Executive Vice President & Chief Medical Officer

Yes. No, absolutely. So a great question around that. So we've seen some activity now as presented by the MD Anderson Group looking at selinexor and pembrolizumab in patients with disease that's refractory to checkpoints. And based on kind of early promising signals there, we're continuing to really confirm the signal there for what the activity that we see with this combination specifically in checkpoint refractory disease. And the field is evolving there, especially in checkpoint naive patients, I think there's still a clear unmet need and opportunity in patients with checkpoint refractory disease. And we're evaluating both those patients who have primary refractory disease or those who have response and then become refractory, those have two different biologies. And based on the data of that, we'll form our guidance in terms of the next steps.

Anna -- JPMorgan -- Analyst

Great, thanks for taking the questions.

Operator

The next question comes from Jonathan Chang from SVB Leerink.

Jonathan Chang -- SVB Leerink -- Analyst

Good morning and thanks for taking my questions. First question, can you remind me what data you have available that gives you color into what lines of treatment and combination XPOVIO is being utilized?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. As you know, it's very difficult to get an accurate picture of lines of therapy, but we do have syndicated data from payer claims data that gives us good coverage on our patients that indicate that shift in line of therapy.

Jonathan Chang -- SVB Leerink -- Analyst

Got it. And second question, and this is a higher-level question. Can you talk about how you're thinking about moving toward being a cash flow positive company in the future, both on the revenue and expense side and how we should be thinking about your strategy in relation to your cash runway?

Jason Finkelstein -- Senior Vice President

I think maybe I'll just start off. I mean, obviously, as we look moving forward, a number of catalysts. First is just continuing to drive our breadth and depth in multi myeloma and continuing to grow in multiple myeloma. And obviously, moving forward, I think with our SIENDO study, as we're talking to that being very near term, and I think also, as you've heard from Jatin, in that opportunity, right now, that's an opportunity which has a very different uptake than you see in multi myeloma, a much more rapid uptake because there is no approved therapy for patients in this setting. And obviously, there's a big incidence population, which would benefit pretty rapidly from having an improvement in the setting of actually having more time to extend in remission when you're looking in endometrial cancer patients.

And then continuing to build on that, obviously, we're bringing other new indications forward. So driving our revenue growth is key. And I think also making sure, as we talk to, that we're very focused in terms of where we invest in terms of having the highest impact for patients and the highest probability of success. And then on top of that, I'll let Mike talk to it, but you've heard some of the talk about our partner revenue and different areas that we're adding in terms of evolving our cash runway. Mike?

Mike Mason -- Senior Vice President, Chief Financial Officer & Treasurer

Sure. Yes, I would -- let's get summary. Just to add. I think, obviously, on the inflow side, our goal with Europe, with potential approval in the first half of 2022 is to be commercially ready there potentially with the partner. So that's certainly one source of capital that's coming in outside of traditional revenues or financing. We also have $40 million remaining on our healthcare royalty finance agreement as another tool in our belt. And as Richard said, and we'll give a lot more color on this in our R&D day in about a month on how we really focus on prioritizing our investments in our pipeline.

Jonathan Chang -- SVB Leerink -- Analyst

Got it, thank you.

Operator

The next question comes from Colleen Margaret Kusy from Baird.

Margaret Kusy -- Baird -- Analyst

Great, thanks so much for taking my questions. Congrats on the quarter. For the top line growth that you saw in 3Q, are you able to comment on between longer duration in new patients, what was more of a driver in 3Q? And looking forward, where you see the bigger opportunity for growth, whether it's adding new patients or prolonging the duration.

Richard Paulson -- President, Chief Executive Officer & Director

Thanks, Colleen. I'll just start at a high level, and then turn it to Sohanya. But again, I think it's a combination of both. As you heard Sohanya talk to, we're going to continue to drive the breadth and depth as we move into earlier lines of therapy, which we've done very well in this quarter with the greatest growth being in -- through the year in that third-line setting. And as we move up into earlier lines, patients have a greater duration of therapy. So it's both in terms of bringing new patients onboard in earlier lines and having a greater duration of therapy through the patients obviously benefiting in the earlier lines. Sohanya anything you want to add to that?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

No, I think that's a great summary, Richard, yes.

Richard Paulson -- President, Chief Executive Officer & Director

Does that address your question, Colleen?

Margaret Kusy -- Baird -- Analyst

Yes, it does. And on the impact from COVID that you saw in 3Q, can you just put that into context versus what you saw in 2Q? And what your expectations are for that in the coming quarters?

Richard Paulson -- President, Chief Executive Officer & Director

So I'll turn to Sohanya on that?

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Yes. So we saw an increase in 3Q field activity and an increasing proportion of our visits being in person versus virtual, but we have not returned to pre-COVID levels. Similar trend on patient visits. While there is a gradual increase over time in patient visits, that also has not returned to pre-COVID. At Karyopharm, we have a nimble, dedicated, very patient-centric team that is able to reach our prescribers to ensure they have the right education. We've also strengthened our digital capabilities to complement field efforts. So we are entirely focused on strong execution. We have to actively monitor the COVID impact and adjust our engagements as needed, but we remain focused on strong execution.

Margaret Kusy -- Baird -- Analyst

Great, thanks so much for taking our questions.

Operator

We have no further questions at this time. I would like to hand back to Richard to conclude. Thank you.

Richard Paulson -- President, Chief Executive Officer & Director

Thank you, operator, and thank you again to everyone for joining our call today. Looking forward to continue to update you on our success as we continue to bring XPOVIO to more patients, not only in multiple myeloma, but also in other key hematological indications in solid tumors with a high unmet need, where we can make a significant impact to positively impact the lives of cancer patients. Thank you for joining us today, and have a great day.

Operator

[Operator Closing Remarks]

Duration: 47 minutes

Call participants:

Jason Finkelstein -- Senior Vice President

Richard Paulson -- President, Chief Executive Officer & Director

Sohanya Cheng -- Head of Sales & Commercial Operations and Senior Vice President of Sales & Commercial Operations

Jatin Shah -- Executive Vice President & Chief Medical Officer

Mike Mason -- Senior Vice President, Chief Financial Officer & Treasurer

Maury Raycroft -- Jefferies -- Analyst

Peter Lawson -- Barclays -- Analyst

David Lebowitz -- Morgan Stanley -- Analyst

Lennette -- RBC Capital Markets -- Analyst

Anna -- JPMorgan -- Analyst

Jonathan Chang -- SVB Leerink -- Analyst

Margaret Kusy -- Baird -- Analyst

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