Image source: The Motley Fool.
DATE
Tuesday, March 24, 2026 at 5 p.m. ET
CALL PARTICIPANTS
- President & Chief Executive Officer — Mark Newcomer
- Chief Financial Officer — Jeffery Baker
- President, Patient Affordability — Matthew Turner
- Chief Payments Officer — Matt Lanford
TAKEAWAYS
- Total Revenue -- $82 million, up 40.5%, with patient affordability and plasma businesses as main contributors.
- Net Income -- $7.6 million, an increase of 98%.
- Adjusted EBITDA -- $19.9 million, rising 107% year over year.
- Operating Margin -- Reached 9% (up from 1.7%), evidencing operating leverage and scalability.
- Patient Affordability Revenue -- $33.9 million, climbing 168%, with claims processed up approximately 79%.
- Plasma Revenue -- $45.6 million, increasing 4%, with the total number of plasma centers up by 115 to 595 (despite lower average donations per center offsetting some revenue growth).
- Dynamic Business Rules Savings -- Platform saved clients over $325 million in 2025 and almost $150 million year-to-date, mitigating costs associated with co-pay maximizer programs.
- Total Active Patient Affordability Programs -- 131 across more than 70 clients, with 55 new programs added during the year.
- Presence in Pharma Market -- Active programs now include 6 of the top 10 U.S. pharmaceutical manufacturers by revenue.
- Cash Position -- $21.1 million, nearly double prior year, and zero bank debt; acquisition funded from operating cash flow.
- 2026 Revenue Outlook -- Projected at $106.5 million to $110.5 million (up 30%-35%), with plasma and pharma expected to contribute equally and $2.5 million expected from other revenue.
- Margin Guidance for 2026 -- Gross profit margin forecast at 60%-62%; operating expenses are expected to rise 20%, with depreciation, amortization, and stock-based compensation detailed separately.
- 2026 Net Income Forecast -- $13 million to $16 million (up nearly 100%), or $0.21 to $0.26 per diluted share; adjusted EBITDA expected between $30 million and $33 million.
- Q1 2026 Guidance -- Revenue expected at $27 million to $27.5 million (up 45.2%-47.8%), with 137 active patient affordability programs and 589 plasma centers targeted at quarter end; operating margin of 20%-22% and adjusted EBITDA margin of 34.5%-36.5% projected.
- Platform Differentiators -- Dynamic business rules capable of delivering "97% efficacy on first fill," with 131 programs and business rules adoption driving higher revenue per specialty claim than retail claims.
- Regulatory Status -- BECS (blood establishment computer system) donor management system currently under FDA 510(k) review, with feedback expected within 60 days.
- Market Trends Noted -- Management described ongoing expansion within large pharma clients, robust pipeline ahead of industry conferences, and no slowdown in pharma client activity, with "push for innovation" cited.
Need a quote from a Motley Fool analyst? Email [email protected]
RISKS
- Average plasma donations per center declined due to elevated plasma inventory, leading to lower average monthly revenue per center despite overall center growth.
- "Fourth quarter net income was impacted by a higher effective tax rate of 45.4%, which reduced earnings per share by $0.02 per fully diluted share versus the prior period," per Chief Financial Officer Jeffery Baker.
- Management cited ongoing investor misunderstanding of the company's co-pay model and highlighted that "the market has been in a show-me state sort of stake with the operating leverage from the patient affordability business."
SUMMARY
Paysign, Inc. (PAYS +37.53%) reported a 40.5% increase in revenue and nearly doubled net income for the year, with patient affordability business scaling to become a central driver. The platform’s dynamic business rules technology generated significant client savings and proved to be a differentiator among competitors. Management issued 2026 guidance reflecting continued margin expansion, notable revenue growth targets, and a near doubling of net income, underpinned by operating leverage and increasing scale in both patient affordability and plasma businesses.
- The company forecasted balanced revenue contributions from both pharma and plasma businesses in 2026, accelerating plasma revenue due to collection efficiencies and normalized capacity utilization.
- Management described competitive positioning as driven by transparency, unique technology, and the ability to provide real-time financial data to clients through proprietary payments infrastructure.
- No material customer attrition or headwinds in core medical/pharmacy segments were indicated; management stated, "we do not view these dynamics as a material threat to our business."
- Q1 2026 is expected to set new highs for pharma segment revenue before seasonal normalization across the year, while plasma segment revenue is projected to ramp after a seasonal low in the first quarter.
- FDA review of a new donor management software system is ongoing, with management expecting to hear back from the FDA within the next 60 days.
- Matthew Turner sees early-stage growth potential for its patient affordability offering, stating, "We're very much in the beginning. And I think we'll continue to see very strong growth out of this vertical for many years to come."
INDUSTRY GLOSSARY
- Dynamic Business Rules (DBR): Proprietary claim-processing logic that optimizes manufacturer co-pay assistance programs by detecting and combating maximizer programs, increasing savings and revenue per claim.
- BECS (Blood Establishment Computer System): Software system for managing donor and collection data in plasma and blood collection centers, subject to FDA 510(k) review for regulatory approval.
- Patient Affordability Platform: Suite of pharma manufacturer services that administers co-pay assistance, optimizes access for high-cost, branded medications, and manages manufacturer spend.
- Maximizer Program: Insurance or pharmacy benefit strategy designed to maximize manufacturer co-pay contributions, frequently increasing costs for drug makers; Paysign’s technology mitigates this impact.
- FDA 510(k) Review: Regulatory premarket evaluation process for certain medical devices, required to demonstrate substantial equivalence to a legally marketed device before U.S. commercialization.
- GLP-1: Glucagon-like peptide-1, a drug class for diabetes and weight loss products, referenced for its volume potential versus specialty drugs in the company’s platform mix.
Full Conference Call Transcript
Mark Newcomer: Thank you, Kevin. Good afternoon, everyone, and thank you for joining us today for Paysign's Year-end 2025 Earnings Call. I'm Mark Newcomer, President and Chief Executive Officer. Joining me today is Jeff Baker, our Chief Financial Officer. Also on the call are Matt Turner, our President of Patient Affordability; and Matt Lanford, our Chief Payments Officer, both of whom will be available for Q&A following our prepared remarks. Earlier today, we announced our fourth quarter and full year financial results for 2025, which demonstrated continued strength and exceptional growth across all key metrics. For the full year, revenue increased 40.5% to $82 million. Net income increased 98% to $7.6 million and adjusted EBITDA increased 107% to $19.9 million.
Importantly, operating margins increased 723 basis points, providing clear evidence that we've reached a key inflection point where future revenue growth should drive increasing operating leverage and profitability. We continue to deliver strong growth in our patient affordability business. Annual revenue grew 168% year-over-year, reaching $33.9 million compared to $12.7 million in 2024 and claims processed increased by approximately 79%. For those newer to our story, our patient affordability platform helps pharmaceutical companies ensure patients can access high-cost medications by administering co-pay assistance programs. In 2025, our platform helped deliver nearly $1 billion in financial assistance to patients, supporting access to high-cost therapies for more than 840,000 individuals.
At the same time, we help manufacturers better control how those dollars are spent, which is one of the key value propositions we provide. A key differentiator of our platform is our dynamic business rules technology, which helps pharmaceutical manufacturers avoid unnecessary costs associated with co-pay maximizer programs. In 2025 alone, this solution saved our clients over $325 million. And this year, we have already saved our clients almost $150 million. That level of savings represents a meaningful economic benefit for our customers and highlights the value of our platform. We added 55 programs during the year, bringing total active programs to 131 across more than 70 patient affordability clients.
A mix of transition programs and new launches contributed to both immediate and long-term revenue growth. Our programs span both retail and specialty pharmacy as well as in-office administered and infused products. Oncology and other cancer treatment products remain a significant portion of our program base and biologics represent approximately 50% of claim volume across the platform. We continue to see strong expansion within our existing client relationships. For example, following the onboarding of one of the nation's largest pharmaceutical manufacturers in 2024, those programs scaled successfully throughout 2025. and we added 4 additional programs from that same manufacturer during the year.
This type of expansion within large pharmaceutical clients highlights both the scalability of our platform and the durability of demand. Paysign now has active programs with 6 of the top 10 U.S. pharmaceutical manufacturers ranked by revenue. Next month, we attend the Asembia Specialty Pharmacy Summit here in Las Vegas. As in prior years, we are seeing strong interest from potential clients evaluating our solutions, and we enter the conference with a robust pipeline. Over the past several months, we've had conversations with shareholders, analysts and prospective investors to help them better understand the patient affordability business and the broader industry landscape in which we operate. Increasingly, those discussions have touched on legislative, regulatory and policy-related topics.
So I thought it would be helpful to ask Matt Turner, our President of Patient Affordability, to provide some additional context.
Matthew Turner: Thank you, Mark. Before addressing some of the questions we've been hearing from investors and analysts about potential headwinds to our business, I want to briefly give an overview of how our patient affordability business fits within the broader health care ecosystem. Our platform is focused on helping pharmaceutical manufacturers support patient access to high-cost branded therapies, primarily within the commercially insured patient population. These are typically branded medications where out-of-pocket cost can be significant and where co-pay assistance programs are essential to ensuring patients can begin and stay on therapy. At the same time, our platform helps manufacturers better manage how those assistance dollars are deployed, particularly in an environment where payer dynamics can introduce inefficiencies into the system.
That combination of improving access while also driving economic value is what underpins the demand for our solutions. With that context, I'll address a few areas we've been asked about. First, on the expansion of the direct-to-consumer, also known as DTC and cash pay models, these programs have existed in various forms for over a decade and are not new. They were built primarily for products with little or no commercial insurance coverage. That is a very different segment from where we operate today.
For the types of high-cost branded therapies on our platform, where list prices can be tens of thousands of dollars, which represents approximately 90% of the drugs in our platform, cash pay and discount alternatives are simply not a viable solution for most patients. Commercial insurance, combined with manufacturer co-pay assistance remains the most effective model for patients. As a result, we view DTC expansion as a complementary solution in certain cases, but not a meaningful substitute for our core business. Second, regarding pharmacy discount programs such as GoodRx, TrumpRx, Cost Plus or similar offerings.
These products have existed for more than 20 years and serve an important role in reducing cost for lower-priced generic medications or for those patients without insurance. They are not designed for nor do they compete with branded specialty medications where commercial insurance and co-pay programs are the standard of care. Our business is squarely focused on that branded drug segment and the more than 850 specialty drugs. So these programs are simply not relevant to what we do. Third, and perhaps most important, given the current policy environment on legislative and regulatory considerations, most of the activity around co-pay accumulator and maximizer programs have taken place at the state level.
And despite ongoing discussions and congressional committees, there has been no meaningful federal action to date nor do we expect any in the foreseeable future. The key reason is simply structural as a large portion of commercially insured Americans are covered under employer-sponsored health plans governed by ERISA, which limits the impact of state-level regulations. We do not see that as changing. As a result, these programs continue to operate despite changes in state laws. Importantly, demand for our dynamic business rule solutions, which helps manufacturers navigate maximizer programs continues to grow. As Mark said, this year, we have already saved our clients almost $150 million that would otherwise have been absorbed by those programs.
So stepping back, we continue to monitor the competitive and regulatory landscape closely. But based on what we see today, we do not view these dynamics as a material threat to our business. If anything, they continue to reinforce the need for solutions like ours, which is reflected in the continued growth of our business and pipeline. Our differentiated dynamic business rules capability is a driving tangible ROI for our pharma customers while we enhance affordability for hundreds of thousands of consumers. Back to you, Mark.
Mark Newcomer: Thank you, Matt. Turning to our plasma donor compensation business. In 2025, plasma compensation contributed $45.6 million in revenue, representing a 4% increase over 2024's $43.9 million. We believe the business will continue to exhibit revenue growth driven primarily by center filling excess capacity rather than new center openings. That said, we do expect a modest number of new center openings in 2026, maintaining our market share of just under 50%. We exited 2025 with 595 centers, an increase of 115 centers over the previous year, and we continue to engage the remaining plasma collection companies who are currently not our customers.
We believe our expanded suite of donor management and engagement tools we acquired last year creates additional opportunities to grow our footprint in this space. As we await FDA 510(k) review of our donor management system, also known as a BECS or blood establishment computer system, we are actively working to integrate the BECS with a number of plasmapheresis device and strengthen our relationship with those manufacturers to make installations and transitions to our solution as seamless as possible. This integration is included in our latest filing with the FDA.
Our broader suite of solutions continue to receive positive feedback from blood and plasma collection organizations across the United States, Europe and Asia, and we are highly encouraged by the long-term growth potential of this business. 2025 marked a meaningful step forward as our patient affordability business scaled and became a central driver of growth and profitability, while our plasma business continued to provide a stable foundation. We believe we are still in the early stages of our patient affordability opportunity and enter 2026 with strong momentum in which to build upon. With that, I'll turn it over to Jeff for additional details on our quarterly and full year-end financial results.
Jeffery Baker: Thank you, Mark. Good afternoon, everyone. As Mark highlighted, the fourth quarter and full year results reflect both strong growth in our patient affordability business and the early benefits of operating leverage across the platform. For 2025, total revenues increased 40.5% to $82 million. Pharma industry revenue increased 167.8% to $33.9 million, driven by the addition of 55 net patient affordability programs launched during the past 12 months and a corresponding increase in monthly management fees, setup fees, claim processing fees and other billable services such as dynamic business rules and customer service contact center support. Process claims increased over 79%.
This growth reflects continued expansion of our platform and increasing demand for solutions that improve patient access while helping manufacturers better manage their co-pay assistance spend. Plasma revenue increased 4% to $45.6 million, primarily due to the addition of 115 net plasma centers adding during the past 12 months, offset by a decline in average plasma donations per center as plasma inventory levels were elevated throughout much of 2025. This led to a reduction in our average monthly revenue per center as compared to the same period in the prior year. We exited the year with 595 centers versus 480 centers at the end of 2024.
Other revenue increased by $671,000 or 36.2%, primarily due to the growth in usage in the number of cardholders of our payroll, retail and corporate incentive programs. More importantly, we are beginning to see the benefits of operating leverage across the business. Total operating expenses were $41.4 million, an increase of 32.6%, well below the revenue growth we experienced, which, coupled with our improved gross profit margin to 59.4% versus 55.1% drove our operating margins to 9% versus 1.7% in the prior year. We have reached an important inflection point where our fixed costs can support meaningful scalability without commensurate increased expenses. So we expect further improvements in these metrics throughout 2026.
This is consistent with what Mark described earlier as patient affordability becomes a larger part of our business, we expect to see continued improvement in margins and operating leverage. Here are a few other important details to point out for the fourth quarter and full year results. For the fourth quarter, our earnings before taxes increased to $2.5 million versus $1.2 million the same period last year. Fourth quarter net income was impacted by a higher effective tax rate of 45.4%, which reduced earnings per share by $0.02 per fully diluted share versus the prior period.
The fourth quarter adjusted EBITDA, which is a non-GAAP measure that adds back stock compensation to EBITDA was $5.4 million or $0.09 per diluted share versus $2.9 million or $0.05 per diluted share for the same period last year. The fully diluted share count for the quarters used in calculating the per share amounts was $61.6 million and $55.5 million, respectively. We exited the year with $21.1 million in cash, almost double from the prior year. This excludes any impact to pass-through receivables and payables we periodically have related to our pharma patient affordability business. We also continue to have zero bank debt, funding operations and our Gamma acquisition through operating cash flow. Turning to our outlook for 2026.
We expect revenue of $106.5 million to $110.5 million, representing 30% to 35% year-over-year growth, with plasma and pharma contributing equally and other revenue contributing $2.5 million. Considering the seasonality in both our main health care businesses, we expect plasma revenue to be the lowest in the first quarter with tax refunds going out and ramp up throughout the remainder of the year, while we expect pharma revenues to be the highest in the first quarter and decline throughout the remaining of the year as patient affordability claims ramp down. This outlook reflects continued momentum in our patient affordability business, which we expect to remain the primary driver of growth.
Gross profit margins are expected to be between 60% to 62%, reflecting increased revenue contribution from our pharma patient affordability business. Operating expenses are expected to increase 20% over 2025 as we continue to make investments in people and technology. Of this amount, depreciation and amortization expense is expected to be between $9.5 million and $10 million, while stock-based compensation is expected to be approximately $5.5 million. Given our large unrestricted and restricted cash balances and the current interest rate environment, we expect to generate interest income of approximately $3.1 million. Our full year tax rate is estimated to be between 22.5% and 25%.
Net income is estimated to nearly double over 2025, reaching a range of $13 million to $16 million or $0.21 to $0.26 per diluted share and adjusted EBITDA to be in the range of $30 million to $33 million or $0.49 to $0.53 per diluted share. The number of fully diluted shares for the year is estimated to be 62.3 million. For the first quarter of 2026, we expect revenue of $27 million to $27.5 million, representing a 45.2% to 47.8% growth over first quarter 2025 and expect to have 137 active patient affordability programs and 589 plasma centers exiting the quarter.
Margins are expected to expand across the income statement versus the same period last year, equating to an operating margin between 20% to 22%, net margin between 17% to 19% and adjusted EBITDA margin between 34.5% to 36.5%. Fully diluted earnings per share is estimated to be $0.07 to $0.08, while adjusted EBITDA per share is estimated to be $0.15 to $0.16. Overall, our outlook reflects continued strong growth driven primarily by our patient affordability business, along with further margin expansion as we scale. With that, I would like to turn the call back over to Kevin for questions and answers.
Operator: [Operator Instructions] Our first question is coming from Jacob Stephan from Lake Street Capital Markets.
Jacob Stephan: Congrats on a really nice quarter here. I appreciate all the color on the pharma industry. One thing I kind of wanted to touch on a little bit. So we're kind of hearing some pharma services providers that the drug manufacturers have actually been kind of less active recently with regards to new initiatives. I'm wondering if you're seeing any difference in behavior with your pharma manufacturers over the last few months here.
Matthew Turner: No. I mean, this is Matt Turner. I would argue that it's just the opposite. If you were at JPMorgan and listening to the conversations there, nobody is slowing down anything. We were sitting there listening to Dave Ricks, the CEO of Lilly, and he was talking about the billions of dollars they're pumping into AI and the fact of doing a deal every 9 days. And almost all the presentations there really pointed to not a slowdown by any means. Everybody's pipelines are really strong right now. Almost every manufacturer has some form of a weight loss or GLP-1 type product in line. FDA calendar for PDUFA this year looks really good.
So no, I mean, I don't really see a slowdown. I would say that the push for innovation is growing overall. And I think that's obviously what we've been trying to provide for the last 7 years as we built out this vertical really is the innovation side of things. So no, I don't see a slowdown from our perspective at all, especially not in the patient affordability business.
Jacob Stephan: Okay. And maybe -- I mean, you did kind of touch on the GLP-1 opportunity. I'm wondering what that looks like for you guys? Do you have any current GLP-1s on the platform? And how are you thinking about attacking that market going forward?
Matthew Turner: Yes. So that's -- we don't have any of the 2 larger GLP-1s that are for weight loss nor do we have the diabetes products. Those are largely retail plays, and we're certainly making a push. We've been making a push in that area. Those drugs have been in market now for a little bit. If you look at those products as well, they're very much -- they're much more of a DTC product than they are a traditional co-pay type product. It's not to say the co-pay offers aren't out there, they are. But it represents a very small subset of that actual volume is going through co-pay.
So there's not a ton of upside on a GLP-1 product used for weight loss. There would be if you're looking at the diabetes side. We have one client that has the GLP-1 product. I think [indiscernible] that's coming to market. I think we're in an excellent position to win that business as we do have a very good portion of their retail as well as almost all of their specialty products. So I think we're in a very good spot to pick up a GLP-1 in the next 12 to 18 months. And I think that's as much as I can really say there.
I don't -- we don't have any commitment saying that it's ours or anything and plus we don't know what the volume is going to look like there. But yes, we're certainly trying to make inroads to get access to more of those programs.
Jacob Stephan: Got it. And then maybe just last one for me. Jeff, you made an interesting comment about fixed cost potentially kind of plateauing, minimal additions kind of needed. I'm wondering, from just looking at the math, that looks like around a $22 million to $23 million quarterly kind of cost basis. I'm wondering if you could kind of give me some more color on that.
Jeffery Baker: Yes. So the comment really on the -- when we talk about fixed cost is like the base cost of what our business has been in 2025. So we looked at our OpEx of $41 million. The incremental costs that we have to add going forward as the business grows is certainly a lot less than what it has been historically. If you look at 2024, we were pushing -- SG&A growth was pretty much tracking with revenue growth. 2025, really strong improvements there. In 2026, we think there's even more operating leverage to win out of that business. So when you look at it, we're going to do a good job trying to control our costs.
We're only looking for SG&A to grow 20%. And when you peel the onion back, keep in mind, some of that growth is related to the acquisition we did in March. It wasn't even in for a full year in 2025. So you have a full year of amortization in 2026. And then you have some stock comp increase about $1.5 million year-over-year. So take those 2, if you -- however you want to look at that and adjust it out or whatever, but our controllable SG&A is really looking very leverageable.
Operator: Our next question today is coming from Gary Prestopino from Barrington Research.
Gary Prestopino: I couldn't write down fast enough. Did you say you were going to exit Q1 with about 137 pharma programs?
Jeffery Baker: Yes, that's correct.
Gary Prestopino: And then -- and what did you say for the plasma? Was it 589?
Jeffery Baker: 589. Yes, we had -- in the first quarter, we had 5 centers get sold to a competitor. So they left us and then 1 center closed. So there are 6 -- those are the 6 centers.
Gary Prestopino: Okay. Okay. That's fine. And then just getting back to when you were talking about like the GLP-1s versus your high-cost branded pharmaceuticals. Is there any difference in the revenue per claim process there if you're doing basically kind of lack of a better word, it's not really a specialty drug, like, say, a cancer and oncology drug?
Matthew Turner: Yes. So I mean each claim type, right, is going to have different potential transactional fees that will attach to it. If you look at the specialty -- and I would say that overall, if you just look at a base, say, pharmacy claim or medical claim, it doesn't really matter if it's specialty or pharmacy, we're going to make on that claim processing fee, we're going to make about the same. But when you look at the bolt-ons that can happen in the specialty space, they compound pretty quickly. A dynamic business rule claim is worth far more to us. than just the singular co-pay claim.
So while the volume around retail products like GLP-1s or any of the cardiovascular drugs, if you go back historically and look at like Crestor, Lipitor, Plavix, Modern Day Brilinta. Sure, there's a lot of volume there, but your chance to make -- to kind of add on the additional functionality that can generate larger revenue is just not there on the retail side, which is one of the reasons we highly target the specialty space because we can make far more money on 1,000 DBR claims than we can on, say, 20,000 retail claims. So profit potential and even bottom line margin is far superior in the specialty space.
That being said, we are working to bring on more retail brands so that we have a very weighted and comprehensive portfolio of products.
Operator: Our next question is coming from Jon Hickman from Ladenburg Thalmann. Our next question is coming from Peter Heckmann from D.A. Davidson.
Peter Heckmann: I had a follow-up, Jeff, on -- in terms of thinking about the guidance for 2026, you talked about equal contribution from plasma and pharma. I assume you're talking about from a dollar of revenue perspective. And if so, that still represents a pretty significant acceleration on the plasma side. I didn't hear in your prepared comments why that might be. And so if you could provide a little bit of additional color in terms of whether that's an increase in revenue per center or anticipation of a big addition of net centers for the year.
Jeffery Baker: Yes. So -- the revenue comment -- the comment on the [ Equal ] business was revenue, both from the plasma and the patient affordability or pharma side. The one of the main drivers in the plasma, if you recall, we had 132 centers in June and July. So we're going to have those uncomped until that time, so midyear. So you're going to see the growth of plasma with those numbers for the first half of the year be much stronger than the second half of the year, obviously. My expectations haven't changed with plasma is that in a normalized year, it's about a 5% grower, and it's a very good cash cow, and we manage the business accordingly.
Mark Newcomer: And let me give a little more color on the plasma revenue growth. The increase in collection efficiencies associated with the latest hardware upgrades effectively gives the average plasma center approximately 10% greater capacity. So a good way to look at that would be for every 10 centers, a collector can now get 11 centers worth of capacity, which is reducing the demand for new center openings. So that just -- it gives them the ability to collect more.
Peter Heckmann: I see. That's helpful. Okay. And then just going back to the Nuvec system. Any feedback so far from the FDA or any thoughts in terms of the potential time line there for the completion of the review?
Mark Newcomer: Yes. I mean it's currently under review. We expect to hear back from them within the next 60 days. And that's kind of about as much as I'll go into at this point. But so far, everything is very positive. We've gone into our substantive review with them.
Operator: Our next question is coming from Jon Hickman from Ladenburg Thalmann.
Jon Hickman: Could you give us some sense of where you are on the pharma side with your kind of part of the market? What's the TAM here? And where -- like are you in the second inning, third inning of growth here? Or can you elaborate?
Matthew Turner: Yes. So we -- this is Matt. We always hesitate to give the TAM because it's very difficult for us to give a TAM for something that you can't -- you just -- there's no way to exactly tell the dollars are wrapped up in marketing amounts and everything else and nobody discloses exactly how much money they're paying these vendors. So we estimate the TAM is somewhere between $500 million to $850 million at any given time. We think with some of the offerings that we have, specifically the dynamic business rules that we are pushing that TAM higher as we're able to generate revenue from some of these unique offerings that we're bringing to the table.
Also, as we continue to build this out and add more features, add more products, we think the TAM can expand even further upwards to $1 billion. Asking about kind of what inning we're in, I think we're in the first inning. There's still a lot of growth potential here. We don't see anything slowing down when it comes to new program acquisition. And if you look at the growth that we're doing year-over-year and not just from a dollar perspective, right, just from also throwing in the number of programs that we're adding in. Last year, it was 1 every 6-point-something days we were putting a new program up.
And hopefully, this year, we have similar metrics as far as the number of programs that we're pulling in. But it's -- we're nowhere near the middle of this at all. We're very much in the beginning. And I think we'll continue to see very strong growth out of this vertical for many years to come.
Jon Hickman: So a follow-up. So are you inviting competition here? Are people starting to pay attention to what you're doing?
Mark Newcomer: There's always really been competition.
Matthew Turner: I mean -- yes.
Mark Newcomer: I mean we've come into the market and really gone up against the competition. And by bringing new functionality, new features to the market, that's part of the reason why we're winning the business.
Matthew Turner: Yes. This was a very stale business that had become almost commoditized. It was treated like just picking something off of the shelf. And that made it very easy for some manufacturers. And of course, they enjoyed that when things like maximizers and accumulators weren't an actual threat to their bottom line. And as that has emerged as a bigger threat, the need for innovation was there. Unfortunately, kind of the legacy dinosaurs in the industry just never reacted. So yes, there's some new players popping up. It just -- that happens every time there's an industry that's ripe for disruption.
I would say the good thing for us is we were ahead of that, and we also helped to cause a lot of the disruption. If you look at how we have sold into this industry, we have -- we've really shaken a lot of things up and forced manufacturers to rethink how co-pay programs should function as a whole, how they should pay for them. The open book pricing that we brought to the table where we're not making shading money that we can't tell people how we're getting paid, like that really was a disruptor to this marketplace.
And if you kind of look at our -- the catapult that we had for growth, you go back to, I think it was 2023 when we -- in June, July, when we put out a webinar around pricing transparency and a lot of things in that area. That was really part of the lift off for us because we did show the industry there's a better way to do this. You can still make money, you can still have everything that you need. Just we can do it in a way that we're not robbing you blind behind your back, which is what a lot of other competitors were doing.
Jeffery Baker: And another thing, Jon, when we look at our competitive advantage, certainly, that's one very important one. Another one is -- and we take it for granted as a payments company, but our competitors don't have the same say, insight into -- for their pharma customers' programs like we do. I mean we give our customers a web portal. They come in, they can see bank balances. They can see transaction data. They see a lot of information that we're able to provide them so they could figure out if their program is successful or not.
And we take that as for granted as it's kind of table stakes as a payments company, but there -- our other competitors don't have that because they're not payments companies. And then the last thing is the dynamic business rules. I can't stress enough the fact that with 97% efficacy on first fill that's completely agnostic to the consumer that is getting their drug that we're able to identify whether that transaction is related to a Maximizer program or not. That's huge. It's unheard of and nobody else in the market has that technology.
Jon Hickman: Okay. One more question. So Matt, what are you most worried about here on this side of the business?
Matthew Turner: That's a tough one. I don't know that right now, we really have a lot of worries. We -- it's pretty positive on our side. If you look at what we've built out, I would say, going back 3 years, it was a lot around personnel and how would we scale this inside with people. It was about finding talent at that point that we could bring in and that could help the organization grow. And we spent the last few years really doing that. We invested a lot of time and energy in bringing the right people in creating a pathway for people that were really good to be able to grow inside the organization.
And now that we have that in place, as you look at over the 55 programs that we brought in last year, we didn't have a growth issue when it came to dealing with people. We had already actually built the systems around that. So we were able to just drag people in, drop them into the right place. We have established training curriculums now. It's become a much easier lift for us. So I would say I don't really have any fears at the moment. It's all positive for us right now. And we look forward to the continued growth that we have. We're looking forward to expanding on the partnerships that we currently have.
Jon Hickman: Nice results.
Matthew Turner: Thank you.
Operator: Our next question is coming from Gary Prestopino of Barrington Research.
Gary Prestopino: Yes. I just have a follow-up. Did you give -- Mark, did you give any indication of your pipeline on the patient affordability side? I mean, at times, you have said that you feel pretty confident you're going to exit the year at x amount of programs. Could you maybe just comment on that?
Matthew Turner: This is Matt. So I don't know that we've ever given that guidance this early in the year. And I'll also kind of point back to our selling cycle is for most of our opportunities is in the 90-day area. We know what the pipeline looks like right now for a number of opportunities. I think we would probably comment on that as we got a little more further down the year, exited the Asembia conference, things like that. That's really where we kind of start to narrow down what we think the pipeline will look like between now and the end of the year.
Plus it gives us a chance to do a better evaluation of the FDA PDUFA calendar and what opportunities out of that, we believe are truly winnable for us. So yes, I don't think we can give a number of programs this early in the year. But hopefully, we can do that in the next quarter if everything lines up right.
Gary Prestopino: All right. And you guys are doing really well. And obviously, the stock market has been a miniature disaster in the last couple of months here. Doesn't look like, obviously, the fundamentals of the business are reflected in the stock price. And I'm just wondering, as you go around and talk to investors, is it that they don't understand what's going on with your company? Is there, say, a fear that artificial intelligence is going to serve maybe your ability with your dynamic business rules? What can you pinpoint as to what is some of the hesitation among investors to grasp the story?
Jeffery Baker: Yes, Gary. So when we talk to investors, everybody obviously understands the plasma business. It's kind of like retail same-store sales type stuff. And I think the biggest -- the market has been in a show-me state sort of stake with the operating leverage from the patient affordability business. Now there's a lot of noise out there always with direct-to-consumer. If you remember back when Donald Trump was going to solve all the pricing issues, he had his own Donald Trump pharmacy and he had his direct-to-consumer initiative. And quite frankly, I mean, they announced that I think there were 30 drugs or something whatever. We had 2 of them on there.
And the pricing on the direct-to-consumer side for -- and again, those are cash paying customers was cheaper if you had insurance than if you paid directly to the consumer. So -- and keep in mind, there's roughly 160 million people out there on private insurance. That's what these co-pay programs are for. It's not for the cash paying customers. So I think there has -- I think people don't necessarily understand co-pay. I know for a fact, they don't understand co-pay. And we're going to work really hard in 2026 to tighten that message to make sure people understand that there is a copay -- the co-pay really exists. There's a market for co-pay.
We have a better mousetrap that nobody else has, and it's showing up in the numbers. And now this year in 2025, you definitely saw the operating leverage possible. I mean our operating margin goes from 1.7% to 9%, and that's not insignificant. And then based on the guidance that I've given, we expect that to go up substantially in 2026 and beyond. So we -- I can't control the stock price or the investor community or whatever, but I think the numbers speak for themselves and eventually, the market is efficient over the long term.
Matthew Turner: And one thing I'll add to, if you look at the other competitors that we have in the marketplace. If you go and look at Cencora, you look at McKesson, they both own co-pay offerings, right? But it's such a small part of their balance sheet that it never gets brought up in an earnings call. So we're really the first public company that's out here talking about this to where analysts are trying to absorb this information because for us, it's not a rounding error for McKesson, for Cencora, this represents a de minimis part of their overall portfolio.
So I think it's also given the Street a chance to catch up to see this as a new offering in the market. And hopefully, they'll get behind this, and we'll have more people understand it. I think the private equity market understands this well. There's a number of private equity funds that have purchased assets like this privately. If you were to go look at the private markets, there's a lot of M&A activity happening in this space, not just the co-pay space, but patient services as a whole. It's constantly changing.
So we had a chance to go down to the Cantor, HCIT conference and meet with a bunch of people and just listen to what they had to say. And it's -- there's a lot of activity in this space. It's just not in the public market. So I think that's part of the headwind for us, too, is explaining that and having people understand that this is -- there's a bigger amount of money at play here than what it just seems like on our side.
Gary Prestopino: What about from the standpoint of your competitive advantages, those dynamic business rules? Is there a feeling out there? And I guess this is a stupid AI question, could AI somehow usurp what you're doing in the market?
Matthew Turner: So I mean, I kind of -- I joke with clients when we talk on the phone that AI can do anything that you can dream of. I just don't know when it's going to be able to do it. I mean AI -- we don't view AI as a threat. We're working internally to build out our own AI-based systems to help us make our algorithm stronger so that we spot maximizers and accumulators easier. I think the other part of that to say is that just because they change what they're doing one time doesn't mean that we won't be right there changing it to find it.
And not to go into a ton of detail, but once I have one patient, and I know that patient is impacted by a maximizer, I can -- it doesn't matter what the plan does. I can back into that patient because I know they were a maximizer patient yesterday. They're probably a maximizer patient today. So we don't think that's really a threat to our business model. We see AI on our side is actually a positive, and we're going to be implementing more of that on the patient affordability side to help us have a stronger, more robust product across our vertical.
Operator: We reached the end of our question-and-answer session. I'd like to turn the floor back over for any further or closing comments.
Mark Newcomer: Thank you, Kevin. In closing, we delivered strong results in 2025. We remain confident in our long-term strategy. I want to thank you all for joining us today, and we look forward to speaking with you again in Q1.
Operator: Thank you. That does conclude today's teleconference webcast. You may disconnect your line at this time, and have a wonderful day. We thank you for your participation today.

