Logo of jester cap with thought bubble.

Image source: The Motley Fool.

Date

Thursday, May 7, 2026 at 8:30 a.m. ET

Call participants

  • Chief Executive Officer — Thomas McCourt
  • Chief Commercial Officer — Tammi Gaskins
  • Chief Medical Officer — Michael Shetzline
  • Chief Financial Officer — Greg Martini

Need a quote from a Motley Fool analyst? Email [email protected]

Takeaways

  • LINZESS U.S. Net Sales -- $272.5 million, up 97% year over year, driven by improved net price and 5% prescription demand growth.
  • LINZESS Net Price Drivers -- Improvement was attributed to elimination of inflationary rebates and favorable timing of gross to net rebate reserves.
  • LINZESS Market Expansion -- FDA accepted a supplementary new drug application for use in children 2 to 5 years with a PDUFA action date of May 24, 2026 and priority review status.
  • U.S. Brand Collaboration Revenue -- $104.2 million, a 169% increase from $38.8 million in prior-year quarter.
  • Total Revenue -- $106.5 million reported for the quarter.
  • GAAP Net Income -- $40.8 million declared in the period.
  • Adjusted EBITDA -- $76.7 million delivered for the quarter.
  • Cash and Cash Equivalents -- $220.5 million at quarter-end, with $105.8 million in accounts receivable expected to be collected before June 15 note maturity.
  • 2026 Debt Repayment Plan -- Management plans to use cash and ongoing LINZESS cash flows to repay the June 2026 convertible note and reduce total debt to approximately $300 million by year-end.
  • LINZESS Full-Year Guidance -- U.S. net sales forecast of $1.125 billion to $1.175 billion, Ironwood revenue guidance of $450 million to $475 million, and adjusted EBITDA greater than $300 million.
  • LINZESS Prescription Growth Outlook -- Company projects low single-digit percentage demand growth for the year, following a 5% increase in the quarter.
  • Apraglutide STARS-2 Trial -- Confirmatory Phase III trial to assess SBS-IF patients, with 124 participants targeted and site initiation on track for the second quarter.
  • Apraglutide Clinical Data -- Pooled long-term safety results consistent with prior studies, showing low discontinuation due to adverse events and no new safety findings.
  • Apraglutide Market Opportunity -- Total addressable market estimated at $4 billion in the U.S. for roughly 8,000 SBS-IF patients dependent on parenteral support 3 or more days per week.
  • Apraglutide Peak Sales Potential -- Tammi Gaskins states, “Based on apraglutide's clinical profile and our market research, we believe that apraglutide has the potential to increase the number of GLP-2 treated patients extend days on therapy and achieve greater than $700 million in peak net sales in the U.S.”
  • STARS-2 Trial Design -- 1:1 randomization of SBS-IF patients (including stoma and colon-in-continuity), primary endpoint is relative parenteral support volume change at week 24, with secondary endpoints including 20% support volume reduction, days off support, and enteral autonomy.
  • Apraglutide Extension Study -- “approximately 1 in 5 or 20% of patients achieved enteral autonomy as of January 2025.” in Phase III long-term extension (STARS Extend).
  • Provider Insights -- Survey data presented at DDW showed 46% of providers prioritized reducing the number of days per week on total parenteral nutrition, while 30% prioritized reducing hours per day.
  • Reimbursement Update -- Ironwood’s commercial expense reimbursement from AbbVie declined 90% from prior year due to completed organizational restructuring, now expected to be representative of future run rate.

Summary

Ironwood Pharmaceuticals (IRWD 3.08%) delivered a significant first-quarter revenue and profit surge, with management citing stronger and more stable net price realization across key channels. New regulatory progress for LINZESS and the approaching potential pediatric indication signal expanding addressable markets, while execution milestones for apraglutide’s STARS-2 trial move the rare disease pipeline forward. Cash position and debt plans suggest robust liquidity and a defined deleveraging path. Clear guidance for 2026 underscores expectations for record U.S. LINZESS net sales and continued profitability, with management projecting steadier sales trends across quarters than in the prior year.

  • Management repeatedly emphasized that LINZESS’s favorable net price dynamics are expected to continue reducing variability in quarterly net sales during 2026 compared to 2025.
  • Enrollment for the STARS-2 confirmatory trial will not apply formal stratification between stoma and colon-in-continuity patients but will be tracked to ensure adequate representation as discussed with the FDA.
  • Management stated intentions to broaden LINZESS life cycle through OTC conversion in partnership with AbbVie, though provided no timing or regulatory detail.
  • The adult irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) segments remain central to LINZESS demand growth according to commercial leadership, with pediatric expansion viewed as incremental.
  • Approximately 1,500 to 2,000 SBS-IF patients currently use GLP-2 therapy in the U.S, indicating substantial potential market expansion for apraglutide.

Industry glossary

  • SBS-IF: Short bowel syndrome with intestinal failure, a rare condition where patients depend on parenteral nutrition due to a significant loss of small intestine function.
  • GLP-2: Glucagon-like peptide-2 analogs, a class of drugs used to enhance intestinal absorption in SBS-IF patients.
  • TPN: Total parenteral nutrition, intravenous feeding used when the gastrointestinal tract is nonfunctional.
  • PDUFA: Prescription Drug User Fee Act, refers to the date the FDA must decide on a drug application.
  • STARS: A series of clinical trials for apraglutide evaluating efficacy and safety in SBS-IF patient populations.
  • Enteral Autonomy: The state where a patient no longer requires parenteral nutrition for nutritional support.

Full Conference Call Transcript

Tom McCourt, our Chief Executive Officer, will begin with a brief overview. Tammi Gaskins, our Chief Commercial Officer, will provide a commercial update, including discussion of the commercial opportunity for apraglutide in short bowel syndrome with intestinal failure. Mike Shetzline, our Chief Medical Officer, will discuss our pipeline and I will review our financial results and guidance. Today's webcast includes slides. So for those of you dialing in, please go to the Events section of our website to access the accompanying slides separately. With that, I'll turn the call over to Tom.

Thomas McCourt: Good morning, everyone and thanks for joining us today to review our first quarter 2026 financial guidance results and business updates. Earlier this year, we laid out our top priorities for 2026, which are maximizing LINZESS, advancing apraglutide and delivering sustained profits and cash flow. We believe these priorities are key to achieving our goals of redefining standard of care for patients suffering from GI and rare diseases, while maximizing shareholder value. During the first quarter, we made significant progress on each of these priorities. First, LINZESS, which continues to be the prescription leader for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation in its 14th year on the market.

We reported an outstanding first quarter financial performance with 97% year-over-year net sales growth for LINZESS, driven primarily by improved net price and supported by 5% prescription demand growth. These first quarter results position us well to achieve our full year 2026 financial guidance, which will return LINZESS to blockbuster status and will set a new all-time high for annual U.S. net sales for the brand since launch. We are also continuing to make progress in bringing LINZESS to younger age groups. In the first quarter, the FDA accepted a supplementary new drug application for LINZESS for the treatment of functional constipation in patients 2 to 5 years of age.

The application received a priority review with a PDUFA target action date set for May 24, 2026. At present, LINZESS is the only FDA-approved drug for the treatment of children 7 years and older with irritable bowel syndrome with constipation and for children 6 to 17 years old for functional constipation. If approved, the indication in children 2 to 5 years old for the treatment of functional constipation would further broaden the clinical utility of LINZESS in younger age groups and we look forward to hearing from the FDA in the coming weeks.

Also in the first quarter, we advanced our STARS-2 confirmatory Phase III clinical trial, assessing apraglutide for the treatment of patients with short bowel syndrome with intestinal failure, including completion of the clinical site feasibility and we remain on track for the clinical site initiation in the second quarter. This past weekend, we had a chance to present findings at Digestive Disease Week meeting in Chicago from the LANDMARK survey which underscores the need for therapies that address multiple dynamics and dimensions of the burden of total parenteral nutrition based on real-world experience of patients suffering from short bowel syndrome with intestinal failure. The survey identified reduction in days of total parenteral nutrition as the top priority for patients.

At DDW, we also presented additional data from the long-term extension study of apraglutide showing a long-term safety profile consistent with previous studies. Dr. Mike Shetzline, our Chief Medical Officer, will share more details of this data later in the call. Finally, in the first quarter, we delivered strong profits with $40.8 million in GAAP net income and $76.7 million in adjusted EBITDA. Looking ahead for the year, we believe the cash flows from LINZESS will continue to fund development and commercialization of apraglutide approved, while simultaneously reducing our debt.

With that, I'll hand the call over to our Chief Commercial Officer, Tammi Gaskins, for a LINZESS commercial update and an overview of the opportunity in short bowel syndrome with apraglutide. Tammi?

Tammi Gaskins: Thanks, Tom and good morning, everyone. As Tom highlighted, the first quarter U.S. net sales of $272.5 million for LINZESS represent a 97% increase compared to the first quarter of 2025, driven by significantly improved net price and 5% year-over-year demand growth for LINZESS. Now I'd like to share some additional context from these results. To start, improved year-over-year net price in the first quarter of 2026 was driven primarily by 2 factors: First, net price benefited from elimination of inflationary rebates across channels, including Medicaid. We expect that this benefit from reduced inflationary rebates to persist throughout 2026 as captured in our full year LINZESS U.S. net sales guidance.

The second factor that contributed to improved net price in the first quarter was favorable time phasing of gross to net rebate reserves as compared to the first quarter of 2025. Looking ahead in 2026, we expect reduced variability in sequential quarterly LINZESS U.S. net sales than occurred in 2025 as a result of more consistent net price across channels in 2026. Additionally, we recognized $104.2 million in U.S. brand collaboration revenue in the first quarter of 2026, which represents a 169% increase compared to $38.8 million in the first quarter of 2025. So in just a minute, Greg will speak to additional first quarter 2026 financial results. Now moving on from LINZESS's performance.

I would like to spend a few minutes on the anticipated commercial potential of apraglutide for SBS-IF. For some context, SBS is a severe organ failure condition resulting from surgical resection of a significant portion of the small intestine, leading to a dependence on parenteral support to meet patients' nutritional needs for survival. And on average, SBS-IF patients require 10 hours a day, 6 days per week of parenteral support, with a severe quality of life burden.

Parenteral support meets patients' nutritional needs for survival but as highlighted by the LANDMARK survey, central line infections, fatigue, central line pain and abdominal pain are all common, highly distressing challenges associated with parenteral support, thereby underscoring the need for therapies to address multiple dimensions of total parenteral nutrition. Now data from the STARS Phase III clinical trial, which is the largest Phase III trial in SBS-IF conducted to date, demonstrated a twofold relative PS volume reduction from baseline at 24 weeks with apraglutide once weekly dosing as compared to placebo. Importantly, these longer-term data have demonstrated that more patients continue to lean off PS with longer exposure to apraglutide.

In our Phase III long-term extension study called STARS Extend, approximately 1 in 5 or 20% of patients achieved enteral autonomy as of January 2025. At DDW this week, we presented new data highlighting the long-term safety profile of apraglutide that was pooled from the STARS clinical program that includes the Phase II STARS Nutrition trial, STARS Phase III trial and the ongoing open-label extension STARS Extend. These data for apraglutide showed a long-term tolerability and safety profile consistent with previous studies, low discontinuation rates due to treatment-emergent adverse events and no new safety observations.

Based on the clinical data generated to date, we believe that apraglutide has the potential to reduce volume and days on parenteral support for patients with SBS-IF. Now turning from data, let's look at the market size. We estimate that there are roughly 18,000 SBS-IF patients across the U.S., Europe and Japan. Within that patient population, we estimate that there are more than 8,000 patients in the U.S. with SBS-IF who are dependent on parenteral support for 3 or more days a week. This group of patients dependent on parenteral support 3 or more days per week represents the total addressable SBS-IF market of more than $4 billion in the U.S.

Based on apraglutide's clinical profile and our market research, we believe that apraglutide has the potential to increase the number of GLP-2 treated patients extend days on therapy and achieve greater than $700 million in peak net sales in the U.S. With that, I'll turn the call over to Mike Shetzline, our Chief Medical Officer, to discuss apraglutide's ongoing clinical development. Mike?

Michael Shetzline: Thanks, Tammi and good morning, everyone. As you've heard today, we're very excited about the opportunity to help more patients with SBS-IF and have generated strong clinical data, some of which can be highlighted through our STARS and STARS Extend trials. Over the past few months, we've made significant progress as we moved towards site initiation of our confirmatory Phase III trial, STARS-2, this quarter. STARS-2 is designed based on our interactions with the FDA to confirm and further support the positive data generated in the STARS Phase III clinical trial. We plan to enroll 124 patients with SBS-IF in a 1:1 randomization. Enrollment will be for the overall SBS-IF patient population, which includes patients with both stoma and colon-in-continuity.

Our primary endpoint for the study will be the same as our prior STARS Phase III clinical trial, evaluating relative parenteral support volume change from baseline for the overall population at week 24. Secondary endpoints also to be measured at week 24 for the overall population include clinical response defined as a 20% reduction in parenteral support volume, number of days off parenteral support per week and enteral autonomy. In designing the Phase II trial, we've incorporated feedback from our prior FDA interactions and leveraged learnings from the positive STARS Phase III trial. In preparing for the STARS-2 trial, we've taken steps to refine and optimize the dose administration instructions.

A key consideration in designing STARS-2 was the dose selection, which we intended to confirm the efficacy and tolerability demonstrated in STARS with patients receiving 3.5 milligrams once weekly of apraglutide. We're getting close to initiating clinical trial sites in anticipation of dosing our first patient and look forward to providing additional updates as we continue to progress. Before turning the call over to Greg, I'd like to take a few minutes to highlight our presence at DDW this week.

As you've heard, we had the opportunity to present pooled long-term safety data on apraglutide as well as new findings from the LANDMARK survey in which surveyed providers emphasized the importance of reducing patients dependent on total parenteral nutrition or TPN, to improve quality of life, reduce line infections and lower the risk of thrombosis. About 46% of providers identified reducing the number of days per week on TPN as a priority attribute for further -- for future therapies and an additional 30% prioritized reducing TPN hours per day. Survey results also highlighted the significant burden associated with long-term TPN dependence among patients with SBS. Our development strategy is informed by what we're hearing from patients in the medical community.

The design of our STARS and STARS-2 clinical trials of apraglutide evaluate multiple dimensions of parenteral support dependence. These real-world insights from providers and patients will help us better target the outcomes that most impact SBS patient lives. Our strong presence at DDW this past week further highlights our commitment to developing life-changing therapies for people living with gastrointestinal and rare diseases through enhanced research and a deeper understanding of the challenges these patients face. With that, I'll turn it over to Greg to review our financial performance in the first quarter. Greg?

Greg Martini: Thanks, Mike and good morning, everyone. I'm happy to walk through the highlights of our very strong first quarter financial performance, beginning on Slide 12. In the first quarter, total revenue was $106.5 million. GAAP net income was $40.8 million and adjusted EBITDA was $76.7 million. We ended the first quarter of 2026 with $220.5 million of cash and cash equivalents on the balance sheet as well as $105.8 million in accounts receivable, which we expect to collect prior to the June 15 convertible note maturity.

As noted in prior updates, we plan to use cash on hand and cash flows generated throughout 2026 to reduce our total debt balance and plan to repay the 2026 convertible note in cash at maturity in June. We also expect to end the year with approximately $300 million of total debt on the balance sheet, less than 1x our expected 2026 adjusted EBITDA. Moving to financial guidance on Slide 13. We are reiterating our 2026 guidance at this time. This includes LINZESS U.S. net sales of between $1.125 billion and $1.175 billion. We continue to expect low single-digit percentage LINZESS prescription demand growth.

We expect Ironwood revenues of between $450 million and $475 million and we expect adjusted EBITDA of greater than $300 million. In summary, 2026 is off to a great start with strong LINZESS performance, a significantly improved financial position relative to 2025 and the impending initiation of the STARS confirmatory -- STARS-2 confirmatory trial. We continue to make progress on executing on our strategic priorities as we strive to redefine the standard of care for patients living with GI and rare diseases. I'd like to close by thanking all of our employees, patients, caregivers and advocates for their shared dedication to advancing life-changing therapies. Operator, you may now open up the line for questions.

Operator: [Operator Instructions] Your first question comes from the line of Mohit Bansal with Wells Fargo.

Mohit Bansal: Congrats on all the progress. So one question I have is on LINZESS. So LINZESS has been very strong in first quarter of '26 and wondering like so the volume growth and improved pricing, it does seem like a very strong quarter. So would love to understand like how -- what is your thought process on the guidance given this quarter? Or is there any onetime item that we need to think about here?

Greg Martini: Yes. Thanks, Mohit. I think overall, we're very encouraged by the first quarter results. Prescription demand, as you noted, 5% in the first quarter is slightly above our full year commentary on low single digits. That is a dynamic that we did anticipate the first quarter to be in line with our expectations that are factored into our overall full year guidance. And from an overall brand performance and improved net price, I would say, again, first quarter was very much in line with our expectations. I think positions us very well for our full year guidance.

And one dynamic that we called out in the prepared remarks is we don't expect the same fluctuation or volatility in quarterly net sales for the rest of this year as we saw in 2025. So I would expect more consistency in the quarterly phasing of LINZESS net sales for 2026, which puts us on a nice trajectory for the full year.

Mohit Bansal: Very helpful. And if I may ask one on apraglutide as well. So I mean, in our chat at DDW, it does seem like there are a lot of patients who are on parenteral nutrition and the expert mentioned that about 70% of them probably could be on -- could be SBS patients -- SBS-IF patients. So in that context, first is like how underpenetrated the market is currently when you talk about GATTEX? And with the ICD-10 code and all, do you -- how do you expect this to improve in terms of penetration of these GLP-2s in this market?

Greg Martini: Tammi, do you want to comment on that?

Tammi Gaskins: Sure. Thanks for the question, Mohit. Just to sort of start at the top, as I mentioned in my remarks, we look at the total SBS population across U.S., Europe and Japan is about 18,000 patients. And then we've distilled that further based on research and the patient claims data codes that you've talked about to identify about 8,000-plus patients who we see as most likely to be prescribed a GLP-2 therapy as based on the definition of having -- requiring parenteral support 3 or more days a week.

Now within that and the numbers that I referenced from a total addressable market of $4 billion, that's looking essentially at that 8,000 patients times the price that we know for the currently available therapy of GATTEX. Within that opportunity, today, we estimate based on public disclosures and available claims data that about 1,500 to 2,000 of those patients are on GATTEX at any given time. So there's still significant opportunity to increase GLP-2 utilization overall and we believe in the potential of a brand such as apraglutide to also help improve adherence or days on therapy to really optimize treatment for those patients.

Operator: Your next question comes from the line of Amy Li with Jefferies.

Katherine Wang: This is Kathy on for Amy. I just wanted to ask a quick question about your plans for life cycle management for LINZESS after LOE. So you've previously alluded to being able to pursue OTC for LINZESS. When can we get an update on that? And have you had any conversations with the FDA on any additional data that you would need to share?

Greg Martini: Thanks, Katherine. Mike, do you want to take that one?

Michael Shetzline: Sure. It's a good question. I mean we've always been impressed with the performance of LINZESS and the availability of it for patients and we have a tremendously large safety database for LINZESS use. So we do think that the product has an opportunity for OTC. We have our ongoing engagement with AbbVie, our partner with a plan for OTC. We'll continue to do that and we look forward to updating you as we get more in the future.

Operator: Next question comes from the line of Jason Butler with Citizens JMP.

Jason Butler: Just a couple on the STARS-2 trial. One, just a clarification point. Are you stratifying CIC and stoma patients in STARS-2? What's your expectation for the proportion of those patients, like 2 different populations that will enroll in the trial? And then just in terms of learnings from the first Phase III trial, how specifically when we think about operationally, what are you doing to make sure your enrollment time lines remain on track? And what's the overlap in sites versus what you used in the prior trial?

Greg Martini: Thanks, Jason. Mike?

Michael Shetzline: Yes. Thanks, Jason. So stratification is a good question. For the STARS-2 program, we're not formally stratifying. This was actually an outcome from our discussions with the agency. It's clearly recognized by the agency and prescribers that CIC, colon-in-continuity and stoma patients have a significant medical need and benefit from GLP-2 therapy. So in our study, our endpoints now, both primary and secondary are aligned with the overall population, which includes colon-in-continuity and stoma patients. However, we do need to show a benefit over the populations. So we'll actually track the recruitment of stoma and CIC patients.

But again, to the point, there's no forced stratification but we'll align to get a representative group for both CIC and stoma patients as we discussed with the agency. In regards to the operational execution, I think this SBS is a complex disorder and we certainly did an excellent job in the original STARS program operationally. As you know, that was a very robust, largest SBS-IF study ever performed. We had a very well-executed trial as demonstrated by the low placebo response and the 2x, as Tammi highlighted, the twice benefit in terms of parenteral support volume reduction.

So we're certainly leveraging that experience on the path forward to STARS-2 and we feel confident in our ability to execute STARS-2 as we did in the original STARS program. We'll continue to use sites we have used in the original trial. We're looking at all the sites carefully. As you know, this is a rare disease. So the number of patients per site is something we have to actively include. So we need to consider that in the calculus. But that's, as Tom mentioned, we did a lot of site feasibility already and we're taking those learnings into as we initiate sites and prepare to dose patients in the near term.

Thomas McCourt: And I think the other piece there, the bottom line on this is, one, working with the sites where we know there are existing patients and we certainly have a track record there. But this is also opening up additional sites because this is all about recruiting patients as fast as we can. And we're certainly going to make the most of the sites we have relationships with but we've identified a number of additional sites that we believe we could also harvest patients from. So I think we're excited to get rolling on this and that will be initiated in the upcoming weeks.

Operator: The next question comes from the line of Chase Knickerbocker with Craig-Hallum.

Chase Knickerbocker: Maybe just on guidance again, sorry, Tom or Greg, maybe just walk me through what went better than expected from a demand generation perspective in Q1? And then what are you keeping in mind or don't expect to recur to drive the decline in volume growth through the year that your guidance implies?

Greg Martini: Yes. Thanks, Chase. This is Greg. So I think as we gave our initial guidance for 2026, we had commented to the low single-digit prescription demand growth and that is still our expectation for this full year. And part of the reason we had anticipated that we may see a slowing in growth relative to 2025 or prior years is, as we enacted this pricing change, we expected that there would be some response and impact to prescription demand. But we were really focused on how we could maximize net sales overall over the remaining life cycle of brand. So we didn't expect that all of that would happen in the first quarter.

We thought this would happen progressively throughout the year. And I would say Medicaid, in particular, is one of those areas that we would expect to potentially have reduced growth in the second half of 2026 or -- for later portions. And so that's really what's factored into the guidance and where the 5% was more in line with expectations to start the year.

Chase Knickerbocker: Got it. Helpful. Maybe just on kind of gross to net through the year. Obviously, there's been quite a bit of change as far as the calculation there over the last 24 months. Can you just help us with how we should think about it sequentially, kind of balancing all the different drivers, including some of the dynamics later in the year with the redesign?

Greg Martini: Yes, absolutely. So I would say the biggest takeaway is full year, we feel very good about our overall forecast, the guidance we provided, which implies a more than 30% increase in net sales relative to 2025. I think to your point, there were quite a few fluctuations in net price throughout the quarters in 2025. In '26, we don't expect that same dynamic to occur because we now have more consistent or less variability in net price across channels. So we do expect more consistent net sales in each quarter in '26 than occurred in 2025. From a growth rate perspective, the quarterly year-over-year comparisons could have some anomalies, I'd say, such as the 97% year-over-year in Q1.

But from a dollar value, we expect more consistency in 2026.

Chase Knickerbocker: Got it. And then just last for me on the expense side. $300 million on EBITDA is seeming like a pretty safe floor at this point. But is there any incremental expense kind of outside of STARS-2 that we should be considering that could kind of materially drive spend sequentially from here?

Greg Martini: Yes. So I think you hit on the key point. As we initiate activities associated with STARS-2, we do expect our R&D expenses will ramp up throughout the remainder of 2026. But to your point, we continue to believe we'll be able to deliver greater than $300 million of adjusted EBITDA for the year.

Operator: Your next question comes from the line of Tom Rosenfeld with Intron Health Research.

Tom Rosenfeld: Tom Rosenfeld [indiscernible] from Intron Health. My first one is, can you talk us through the magnitude of the opportunity to invest in functional constipation in 2 to 5 year-olds and whether you anticipate any material revenues from this label expansion in H2.

Greg Martini: Yes. Thanks, Dominic (sic) [ Tom ]. I'm going to ask Tammi to speak to the opportunity we see with 2- to 5-year-olds pending an approval.

Tammi Gaskins: Yes. Thanks, Tom. First, we're very excited about the potential opportunity to extend -- expand and offer a -- potentially offer a prescription therapy for an additional pediatric patient population. We do expect that if approved, the 2 to 5, will support additional demand for LINZESS overall but we still see the adult IBS-C, CIC population as the main driver of growth over the next few years. So yes, all these additional pediatric indications add to supporting demand but the real continued inflection will come from the adult population.

Tom Rosenfeld: That's really helpful. And one more question, if I may. So AbbVie's reimbursement for the Ironwood commercial expenses was down 90% this quarter versus the prior year. Is that around the right run rate we should assume going forward?

Greg Martini: Yes. So if you recall, in first quarter of 2025, we completed a restructuring of our organization, which reduced the Ironwood portion of the selling efforts for LINZESS. So I would say first quarter 2026 is more representative of a run rate for the remainder of this year in terms of those reimbursements.

Operator: We have no further questions at this time. Ladies and gentlemen, that concludes today's call. Thank you all for joining. You may now disconnect.