There aren't too many biotechs around that are as hot as Incyte Corporation (NASDAQ:INCY) is right now. Incyte's stock might be down a little year to date, but shares have surged since April. Can Incyte keep the momentum going in the new year? I think so. Here are three reasons why the biotech's stock could soar in 2017.

1. Jakafi's monopoly

Incyte's JAK1 inhibitor Jakafi has gone over five years without a competitor in the myelofibrosis market. With Gilead Sciences' (NASDAQ:GILD) myelofibrosis candidate momelotinib failing to prove more effective than Jakafi in late-stage studies, it appears that Incyte will retain its virtual monopoly in the indication.

Woman in white coat and safety glasses, examining vials on a table in a laboratory

Image source: Getty Images.

The great news is that Jakafi has plenty of room to run. Incyte has around a 50% market penetration in the myelofibrosis indication and only 10% penetration in the polycythemia vera indication. Jakafi should be able to reach annual revenue of $1.5 billion for the two indications in the U.S., where Incyte holds commercialization rights. Novartis has rights to the drug outside of the U.S.

There are no worries about patent exclusivity, either. Jakafi's U.S. patents don't expire until 2027. That gives Incyte plenty of time to make plenty of money. I expect strong growth from Jakafi will help drive the biotech's earnings -- and share price -- higher next year.

2. Loaded pipeline

Incyte's pipeline is loaded with potential. Another JAK1 inhibitor, baricitinib, had great results in multiple late-stage clinical studies targeting treatment of rheumatoid arthritis. One of those studies found that the experimental drug outperformed the current leading rheumatoid arthritis drug, Humira.  

Lilly (NYSE:LLY), which licensed baricitinib from Incyte, has filed for regulatory approval of the drug in the U.S. and Europe. Incyte stands to receive $165 million in milestone payments if baricitinib wins both approvals. Lilly will also pay tiered royalties between 20% and 29% to Incyte on all sales of the drug. Steven Stein, Incyte's chief medical officer, said at the Piper Jaffray healthcare conference that he expects a "slow and steady uptake" if baricitinib gains approval.

Stein also stated that he is "proudly cautious" about the potential for epacadostat. The experimental drug is in a late-stage study as a potential first-line treatment for melanoma in combination with Merck's Keytruda. Final data from this study is expected in 2018.   

Incyte's pipeline also includes several other candidates that aren't as far along in development. One that stands out especially is the company's fibroblast growth factor receptor (FGFR) candidate targeting treatment of bladder cancer and bile duct cancer. Steven Stein thinks this FGFR drug has "best in class" chemistry and could be poised for accelerated approval in the U.S.

3. Potential acquisition target

Incyte is frequently mentioned as a potential acquisition target. Many investors expect (and hope) that Gilead Sciences will buy Incyte.

In many respects, Incyte would be a great fit for Gilead -- especially after the disappointment with momelotinib. Gilead's CEO John Milligan stated that the big biotech is especially interested in beefing up its oncology portfolio. Incyte would check off that box perhaps better than any other company.

However, Milligan has also said that some deals "might look good on spreadsheets" but would be difficult to manage. I wouldn't be surprised if he has been pestered everywhere he goes about buying Incyte. Milligan's spreadsheets comment just might be a veiled reference to Incyte.

It's possible that Gilead would prefer to make one or more smaller acquisitions rather than spend most of its cash on Incyte. Even if Gilead passes, though, other big companies could be interested in Incyte -- perhaps even one of the biotech's current partners.  

Happy New Year

I don't see any reason to doubt that Jakafi's success will continue. My view is that the odds for approval of baricitinib are pretty high. Both of these should be positive catalysts for Incyte next year. What about the chances of Incyte being bought? There's a reasonable possibility, although I wouldn't recommend buying the stock solely on acquisition potential.

There's still time left in this year. I think Incyte's stock could wind up posting a small gain in 2016. Even if it doesn't, my hunch is that the biotech's shareholders are in for a good year in 2017.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.