Team Rule Breakers
What happens when a Rule Breaker wins the war and starts setting the rules in the market it created? Do we declare victory and move on? Vertex Pharmaceuticals (NASDAQ:VRTX) joined the Rule Breakers scorecard in January 2005. Shares are up more than 50-fold since, roughly 3,747 percentage points ahead of the S&P 500 over those 20-plus years.
- The market it created is mature: Vertex's cystic fibrosis drugs address more than 90% of mutations, and most eligible patients in developed markets are already on a therapy. In this industry, that usually starts investors worrying about patent expirations and the end of the party.
- Disruption is built into its DNA: Vertex turned the cash from those therapies into a war chest. It created a new class of non-opioid painkillers while opioid addiction ravages parts of the country. It helped deliver the first approved functional cure for sickle cell disease. Now it's pushing into kidney disease with the same focus that made it synonymous with cystic fibrosis.
The thread running through Vertex isn't cystic fibrosis. It's excellence in drug design and business development. As the company straddles Rule Breaker and Rule Maker, its maturity becomes its strength.
Team Rule Breakers has a five-year price prediction of $1,061. It trades around $550 today.