The company is licensing a compound from Bayer AG
The new approach by deCODE finally helps answer some of the questions surrounding its business model. With the collapse of such genomics-based stocks as Human Genome Sciences
The new deal between Bayer and deCODE is rather intriguing because it turns traditional drug discovery on its head. The usual paradigm has been to screen a boatload of molecules for disease-treating properties, then figure out what it did, send it through trials, and hopefully get one of those 100,000 molecules approved as a new drug.
deCODE has reversed the drug discovery process by first identifying the target through their genetic research and, instead of trying to design or screen its own compounds, the researchers hunted for a drug that already possessed the desired properties. Now, instead of going through the initial screening and phase I trial, they have a compound ready to leap into phase II, thanks to the development time and money Bayer has already forked into it. Of course, deCODE will have to pay Bayer milestone payments and royalties if the drug progresses successfully through trials, in a role reversal of the usual relationship between biotech and pharmaceutical companies.
deCODE's stock has been on a tear recently, rising from about $3 three months ago to over $8, fueled by a string of genetic discoveries and the resulting milestone payments from its research partners. With such a rapid rise, the company has an enterprise value of about $450 million. Like most biotech companies, it's losing money, albeit at a slower rate than last year, with the third-quarter loss shrinking to just over $1 million, but the burn rate will likely increase as the company begins its clinical trial.
Time will tell if deCODE can cipher the riddle of profitability.
David Nierengarten, Ph.D., works with a biotechnology venture capital fund. He often contributes to Fool.com and is an active member of the TMF Community as DavidMN. He does not own shares of any of the companies mentioned in this article. He appreciates your comments at firstname.lastname@example.org and on the Biotechnology discussion board.