AstraZeneca (AZN -0.25%) announced changes in its top management team in an official statement released today.The crucial post of president of research and development, currently held by the departing Martin Mackay, is to be eliminated and replaced by three individuals responsible for different pharmaceutical segments.

In addition, the company's top sales executive, Executive Vice President of Global Commercial Tony Zook, is to leave the company. His position will also be eliminated and carried out by three managers, each responsible for a different commercial region -- North America, Europe, and international.

The shakeup comes several months after the appointment of current CEO Pascal Soriot, who took his position last summer following the sudden retirement of his predecessor, David Brennan.