Please ensure Javascript is enabled for purposes of website accessibility

The Surprising Thing Most of 2014's Top 10 Stocks Have in Common

By Keith Speights - Jan 11, 2015 at 10:03AM

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

8 out of 10 of last year's best-performing stocks have this one important common denominator.

Are you good at spotting patterns? Most of us are. We even spot patterns when they're really not there -- like seeing faces in clouds.

The list below of 2014's top 10 stocks with a market cap above $300 million, however, reveals a very real pattern -- and one that might be surprising. See if you can identify what it is.

Rank Stock Return Sector Industry
1 Avanir Pharmaceuticals (NASDAQ: AVNR)  404.5%  Healthcare  Biotech & Pharma
2 Agios Pharmaceuticals (AGIO 3.95%)  367.8%  Healthcare Biotech & Pharma
3 bluebird bio (NASDAQ: BLUE) 337.2%  Healthcare  Biotech & Pharma
4 Receptos (NASDAQ: RCPT) 322.6%  Healthcare  Biotech & Pharma
5 Achillion Pharmaceuticals (NASDAQ: ACHN) 269.1%  Healthcare  Biotech & Pharma
6 PTC Therapeutics (NASDAQ: PTCT) 205.1% Healthcare Biotech & Pharma
7 Tetraphase Pharmaceuticals (NASDAQ: TTPH)  193.7% Healthcare Biotech & Pharma
8 Hawaiian Holdings (NASDAQ: HA) 170.5% Consumer Discretionary Passenger Transportation
9 Chimerix (NASDAQ: CMRX) 166.4% Healthcare Biotech & Pharma
10 Skyworks Solutions (NASDAQ: SWKS) 156.4% Technology Semiconductors

Common denominator
This little exercise was probably very easy. A whopping eight of the top 10 best-performing stocks from last year all belonged to the healthcare sector and, more specifically, the biotech and pharma industry. It's probably no surprise that biotech and pharma were well represented among the best stocks of 2014 -- but to this extent? Investors looking for big wins in 2015 should try to understand why this dominating performance happened and whether it's repeatable.

Each of those eight healthcare stocks experienced catalysts from promising clinical trial results. Top-ranked Avanir Pharmaceuticals announced positive results for an experimental Alzheimer's disease drug in September. That good news was followed a few months later by a $3.5 billion buyout offer from Otsuka Pharmaceuticals

Second-ranked Agios Pharmaceuticals received boosts throughout 2014 from continued good news related to its pipeline, including leukemia drug AG-120. The company has also benefited from its relationship with Celgene, which has a collaboration deal with Agios and owns over 4 million shares of the smaller biotech. 

Looking to the future
We could go one by one through the others to find out about the clinical results that turbocharged each stock, but that won't necessarily help investors in finding 2015's versions of Avanir, Agios, and the other top stocks from last year. Instead, let's look to the future to see which biotechs could have promising potential over the next 12 months. A couple to watch closely include Exelixis (EXEL 0.37%) and NPS Pharmaceuticals (NASDAQ: NPSP).

Exelixis had an awful 2014, with shares plunging nearly 80%. That dismal performance came on the heels of disappointing results for its drug Cometriq in treating prostate cancer. However, the small biotech gets another chance with the drug in 2015. Results from a phase 3 trial of Cometriq as a kidney cancer treatment are expected in second quarter of 2015. 

NPS Pharmaceuticals experienced an up and down year in 2014. The FDA is scheduled to announce a decision on hypoparathyroidism drug Natpara by Jan. 24. Good news would no doubt send the stock considerably higher.

Of course, just as with the big winners from last year, there's no way to know in advance whether clinical results or FDA decisions will be positive or negative. One important thing to remember when investing in this industry is that the biggest potential for gain also comes with the biggest risk. 


Keith Speights owns shares of Celgene. The Motley Fool recommends Celgene and Exelixis. The Motley Fool owns shares of Skyworks Solutions. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

Invest Smarter with The Motley Fool

Join Over 1 Million Premium Members Receiving…

  • New Stock Picks Each Month
  • Detailed Analysis of Companies
  • Model Portfolios
  • Live Streaming During Market Hours
  • And Much More
Get Started Now

Stocks Mentioned

Exelixis, Inc. Stock Quote
Exelixis, Inc.
$21.52 (0.37%) $0.08
Celgene Corporation Stock Quote
Celgene Corporation
Agios Pharmaceuticals, Inc. Stock Quote
Agios Pharmaceuticals, Inc.
$29.74 (3.95%) $1.13

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

Related Articles

Motley Fool Returns

Motley Fool Stock Advisor

Market-beating stocks from our award-winning analyst team.

Stock Advisor Returns
S&P 500 Returns

Calculated by average return of all stock recommendations since inception of the Stock Advisor service in February of 2002. Returns as of 08/07/2022.

Discounted offers are only available to new members. Stock Advisor list price is $199 per year.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.