Upstream Bio

(NASDAQ) UPB

Current Price$9.07

Market Cap$494.68M

Since IPO (2024)-59%

5 YearN/A

1 Year+3%

1 Month-8%

Upstream Bio Financials at a Glance

Market Cap

$494.68M

Revenue (TTM)

$2.85M

Net Income (TTM)

$143.44M

EPS (TTM)

$-2.66

P/E Ratio

-3.41

Dividend

$0.00

Beta (Volatility)

1.20 (Average)

Dividend

$0.00

Beta (Volatility)

1.20 (Average)

Price

$9.07

Volume

456,143.446

Open

$8.88

Price

$9.07

Volume

456,143.446

Open

$8.88

Previous Close

$9.09

Daily Range

$8.80 - $9.35

52-Week Range

$7.25 - $33.68

Dividend

$0.00

Beta (Volatility)

1.20 (Average)

Price

$9.07

Volume

456,143.446

Open

$8.88

Previous Close

$9.09

Daily Range

$8.80 - $9.35

52-Week Range

$7.25 - $33.68

UPB News

Upstream Bio (UPB) Q2 R&D Soars 169%

Motley Fool Markets TeamAug 6, 2025

UPB: Motley Fool Moneyball Superscore

Our CEO Is Handing Members His Secret Weapon

It's called Motley Fool Moneyball, our new proprietary AI tool

We spent over half a million dollars in R&D to build a tool that makes stock research faster, sharper, and smarter. Our analysts use it every day, and now, you can too.

Get Access Now

About Upstream Bio

Industry

Biotechnology

Sector

Health Care

Employees

CEO

E. Rand Sutherland, MD

Website

www.upstreambio.com

Headquarters

Waltham, MA 02451, US

UPB Financials

Key Financial Metrics (TTM)

Gross Margin

97%

Operating Margin

-56%

Net Income Margin

-50%

Return on Equity

-35%

Return on Capital

-47%

Return on Assets

-41%

Earnings Yield

-29.33%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$494.68M

Shares Outstanding

54.42M

Volume

456.14K

Avg. Volume

1.26M

Financials (TTM)

Gross Profit

$2.67M

Operating Income

$160.36M

EBITDA

$160.36M

Operating Cash Flow

$133.28M

Capital Expenditure

$165.00K

Free Cash Flow

$133.28M

Cash & ST Invst.

$341.51M

Total Debt

$1.27M

Upstream Bio Performance Analysis

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name

Q4 2025YOY CHG

Revenue

$668.00K

+9.0%

Gross Profit

$611.00K

-0.3%

Gross Margin

91.47%

N/A

Market Cap

$494.68M

N/A

Market Cap/Employee

$9.51M

N/A

Employees

N/A

Net Income

$42.46M

-99.9%

EBITDA

$46.11M

-75.5%

Quarterly Fundamentals

Name

Q4 2025YOY CHG

Net Cash

$340.24M

-27.4%

Accounts Receivable

$668.00K

-43.4%

Inventory

$0.00

N/A

Long Term Debt

$549.00K

-51.4%

Short Term Debt

$720.00K

+2.3%

Return on Assets

-40.55%

N/A

Return on Invested Capital

-47.12%

N/A

Free Cash Flow

$30.68M

-55.0%

Operating Cash Flow

$30.63M

-56.2%

Other Investments to Explore

People Also Watch

SymbolSymbol / CompanyCompanyPricePrice Chg

ZBIOZenas BioPharma, Inc.

ZBIOZenas BioPharma, Inc.$19.64+1.92%

AMLXAmylyx Pharmaceuticals, Inc.

AMLXAmylyx Pharmaceuticals, Inc.$14.73-3.09%

WVEWave Life Sciences Ltd.

WVEWave Life Sciences Ltd.$7.18-0.83%

NVAXNovavax, Inc.

NVAXNovavax, Inc.$10.11+9.53%

NTLAIntellia Therapeutics, Inc.

NTLAIntellia Therapeutics, Inc.$14.09+2.77%

SNDXSyndax Pharmaceuticals, Inc.

SNDXSyndax Pharmaceuticals, Inc.$21.49+4.63%

PHVSPharvaris N.V.

PHVSPharvaris N.V.$30.09+1.38%

Trending Stocks

SymbolSymbol / CompanyCompanyPricePrice Chg

RXTRackspace Technology

RXTRackspace Technology$5.49+0.56%

TSLLDirexion Shares ETF Trust - Direxion Daily Tsla Bull 2x Shares

TSLLDirexion Shares ETF Trust - Direxion Daily Tsla Bull 2x Shares$15.62+0.08%

IRENIren

IRENIren$61.20+0.08%

NOKNokia

NOKNokia$12.82+0.04%

POETPoet Technologies

POETPoet Technologies$10.95+0.14%

TQQQProShares Trust - ProShares UltraPro Qqq

TQQQProShares Trust - ProShares UltraPro Qqq$76.28+0.07%

SQQQProShares Trust - ProShares UltraPro Short Qqq

SQQQProShares Trust - ProShares UltraPro Short Qqq$42.57-0.07%

Questions About UPB

What is the current price of Upstream Bio?

Upstream Bio is trading at $9.09 per share.

What is the 52-week range for Upstream Bio?

Over the past 52 weeks, Upstream Bio has traded between $7.25 and $33.68.

How much debt does Upstream Bio have?

As of the most recent reporting period, Upstream Bio reported total debt of $1.27M.

How much cash does Upstream Bio have on hand?

Upstream Bio reported $101.58M in cash and cash equivalents in its most recent financial results.

What is Upstream Bio’s dividend yield?

Upstream Bio does not currently have a dividend yield.

Upstream Bio

Upstream Bio Financials at a Glance

UPB News

Upstream Bio (UPB) Q2 R&D Soars 169%

UPB: Motley Fool Moneyball Superscore

Our CEO Is Handing Members His Secret Weapon

About Upstream Bio

UPB Financials

Key Financial Metrics (TTM)

Stock Overview

Financials (TTM)

Upstream Bio Performance Analysis

Revenue Growth Rate

Earnings Per Share Growth Rate

Quarterly Performance

Quarterly Fundamentals

Other Investments to Explore

People Also Watch

Trending Stocks

Questions About UPB

What is the current price of Upstream Bio?

What is the 52-week range for Upstream Bio?

How much debt does Upstream Bio have?

How much cash does Upstream Bio have on hand?

What is Upstream Bio’s dividend yield?

Premium Investing Services