Accessibility Menu
 

Upstream Bio

(NASDAQ) UPB

Current Price$9.92
Market Cap$543.66M
Since IPO (2024)-55%
5 YearN/A
1 Year+14%
1 Month+15%

Upstream Bio Financials at a Glance

Market Cap

$543.66M

Revenue (TTM)

$2.85M

Net Income (TTM)

$143.44M

EPS (TTM)

$-2.66

P/E Ratio

-3.75

Dividend

$0.00

Beta (Volatility)

1.21 (Average)

Price

$9.92

Volume

6,613

Open

$9.91

Previous Close

$9.99

Daily Range

$9.78 - $9.98

52-Week Range

$7.25 - $33.68

UPB News

UPB: Motley Fool Moneyball Superscore

59

Our CEO Is Handing Members His Secret Weapon

It's called Motley Fool Moneyball, our new proprietary AI tool

We spent over half a million dollars in R&D to build a tool that makes stock research faster, sharper, and smarter. Our analysts use it every day, and now, you can too.

Get Access Now

About Upstream Bio

Industry

Biotechnology

Employees

75

CEO

E. Rand Sutherland, MD

Headquarters

Waltham, MA 02451, US

UPB Financials

Key Financial Metrics (TTM)

Gross Margin

97%

Operating Margin

-56%

Net Income Margin

-50%

Return on Equity

-35%

Return on Capital

-47%

Return on Assets

-41%

Earnings Yield

-26.67%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$543.66M

Shares Outstanding

54.42M

Volume

6.61K

Short Interest

0.00%

Avg. Volume

1.31M

Financials (TTM)

Gross Profit

$2.67M

Operating Income

$160.36M

EBITDA

$160.36M

Operating Cash Flow

$133.28M

Capital Expenditure

$165.00K

Free Cash Flow

$133.28M

Cash & ST Invst.

$341.51M

Total Debt

$1.27M

Upstream Bio Performance Analysis

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name
Q4 2025YOY CHG

Revenue

$668.00K

+9.0%

Gross Profit

$611.00K

-0.3%

Gross Margin

91.47%

N/A

Market Cap

$543.66M

N/A

Market Cap/Employee

$10.45M

N/A

Employees

52

N/A

Net Income

$42.46M

-99.9%

EBITDA

$46.11M

-75.5%

Quarterly Fundamentals

Name
Q4 2025YOY CHG

Net Cash

$340.24M

-27.4%

Accounts Receivable

$668.00K

-43.4%

Inventory

$0.00

N/A

Long Term Debt

$549.00K

-51.4%

Short Term Debt

$720.00K

+2.3%

Return on Assets

-40.55%

N/A

Return on Invested Capital

-47.12%

N/A

Free Cash Flow

$30.68M

-55.0%

Operating Cash Flow

$30.63M

-56.2%

Other Investments to Explore

People Also Watch

Symbol / CompanyPricePrice Chg
ZBIOZenas BioPharma, Inc.
$21.14-3.09%
NVAXNovavax, Inc.
$8.65-2.09%
WVEWave Life Sciences Ltd.
$7.59+1.40%
AMLXAmylyx Pharmaceuticals, Inc.
$17.64-3.92%

Trending Stocks

Symbol / CompanyPricePrice Chg
TSLLDirexion Shares ETF Trust - Direxion Daily Tsla Bull 2x Shares
$13.26-0.05%
NOKNokia
$10.56+0.02%
TQQQProShares Trust - ProShares UltraPro Qqq
$57.98-0.01%
FRMIFermi
$5.38-0.18%

Questions About UPB

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.