Novavax (NVAX) Q1 2020 Earnings Call Transcript

Novavax (NVAX)
Q1 2020 Earnings Call
May 11, 2020, 4:30 p.m. ET

Contents:

• Prepared Remarks
• Questions and Answers
• Call Participants

Prepared Remarks:

Operator

Ladies and gentlemen, thank you for standing by, and welcome to the Novavax first-quarter 2020 financial results conference call. [Operator instructions] It is now my pleasure to introduce associate director of IR-PR, Erika Trahan.

Erika Trahan -- Investor and Public Relations

Thank you, Operator. Good afternoon and thank you to everyone who has joined today's call to discuss our first-quarter 2020 operational highlights and financial results. A press release announcing earnings is currently available on our website at novavax.com and an audio archive of this conference call will be available on our website later today. Joining me today are Stan Erck, president and CEO; John Trizzino, chief business officer and chief financial officer; Dr.

Gregory Glenn, president of research and development will be available for our Q&A portion of the call. Before we begin with prepared remarks, I need to remind you that we will be making forward-looking statements during this teleconference that could include financial, clinical or commercial projections. Statements relating to future financial or business performance or strategy and other financial and business-related matters, including expectations regarding revenue, operating expenses, cash usage in clinical development and anticipated milestones are forward-looking statements within the meaning of the Private Securities Litigation Reform Act. Novavax cautions that these forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change over time.

I'll now hand it over to Stan to get the call started.

Stan Erck -- President and Chief Executive Officer

Thanks, Erika. And thanks to all of you listening to this call. First and foremost, given the ongoing COVID-19 pandemic, I sincerely hope everyone on the call and all of your respective families is well and safe. I'll start the call today by discussing the historic funding from CEPI for our coronavirus vaccine candidate that we just announced a few minutes ago and provide a brief status on our activities around NVX-CoV2373.

I'll then provide a recap of the positive Phase 3 results for NanoFlu that we announced back in March, following a quick update on our ResVax program. John Trizzino will then provide a financial overview. After that, Greg Glenn, John, and I will be available for questions. As a prelude to my remarks, I just want to say that our accomplishments so far in 2020, including our progress in our influenza and COVID-19 vaccine programs are the most impressive in the company's history.

So let's get started. Beginning with our coronavirus program, we are thrilled that CEPI has chosen to invest up to $388 million of funding in support of 2373. As CEPI's CEO indicated, this arrangement represents CEPI's single biggest investment to date. This CEPI funding will allow us to advance our candidate through Phase 2.

It will also support the rapid scale-up of the vaccine antigen and our proprietary Matrix-M adjuvant, the critical components of 2373. In addition, this funding will allow us to dramatically increase our large-scale manufacturing capabilities. As we previously announced, we identified 2373, which will incorporate Matrix-M, to enhance our immune response and immediately begin testing in preclinical studies. Our studies have shown 2373 is highly immunogenic in animal models, including mice and nonhuman primates, high levels of spike protein-specific antibodies with ACE-2 human receptor binding domain blocking activity.

And SARS-CoV-2 wild-type virus neutralizing antibodies were observed after a single immunization. In addition, the already high microneutralization titers seen after one dose increased eight-fold with a second dose. It is generally accepted that high-titer microneutralizing antibodies are evidence that the vaccine is likely to be protective in humans. We are now launching our Phase 1/2 trial, clinical trial of 2373.

In a few days, we will initiate a placebo-controlled observer-blinded Phase 1 portion of the clinical trial in approximately 130 healthy adults in Australia. Key assessments include the dosage amount and number of vaccinations. The Phase 2 portion of the trial will likely begin in Australia and the US, importantly, we are just a couple of months away from human clinical data as immunogenicity and safety results from the Phase 1 are expected in July. As I mentioned earlier, the additional funding from CEPI will have a significant impact on our ability to quickly begin manufacturing.

It will now be possible for us to begin manufacturing the vaccine with a target of manufacturing 100 million doses by the end of 2020 and with the goal of escalating production to 1 billion doses in 2021. I should point out that these production goals are based upon two key assumptions. Those assumptions are regarding the actual dose of the approved product in the manufacturing yields that we actually achieve at a large scale. We previously announced an agreement with Emergent BioSolutions to provide contract development and manufacturing services, including supply Novavax with GMP vaccine products for Phase 1 and Phase 2 clinical trials.

We are also exploring larger-scale manufacturing capabilities globally. Details of those efforts will be forthcoming in the coming months. The significance of this funding cannot go understated, nor can our appreciation for CEPI's vote of confidence in our technology platform and progress. I'd also like to reiterate my thanks to everyone at Novavax.

It has been an enormous undertaking to get this program up and running since January, although we have made major progress in a very short period of time to make this vaccine a reality. Now let's move on to Novavax's most advanced program, NanoFlu, our recombinant quadrivalent seasonal influenza vaccine. While COVID-19 has grabbed the world's attention, we believe that NanoFlu will also be a game-changer for the prevention of influenza. The Phase 3 data we delivered validates its potential.

Given our detailed March update for the program upon announcement of the Phase 3 results, I'll just provide a high-level recap today. To put it simply, we achieved every single one of our goals in the Phase 3 trials. The trial included 2,650 clinically stable adults, 65 years of age, and older at 19 US sites. It was randomized one to one between NanoFlu and Fluzone subjects were given a single vaccination.

The data we've presented to date has been the 28-day results. The trial's primary objectives were to demonstrate non-inferior immunogenicity of NanoFlu compared to Fluzone Quadrivalent using the day 28 ratio of geometric mean titers and the differences of zero conversion rates. Our primary objectives also included the overall safety of NanoFlu. We've measured immunogenicity by HAI assays using egg-derived reagents.

We achieved the primary endpoints for all strains included in the vaccine. The NanoFlu was well-tolerated and had a safety profile comparable to Fluzone Quadrivalent. The secondary endpoints, which evaluate the immunogenicity using both egg-propagated virus and wild-type reagents for all four actually homologous strains and select drifted strains at day 28. For these endpoints, NanoFlu demonstrated significantly higher geometric mean titers and zero conversion rates than Fluzone Quadrivalent across all four strains included in the vaccine and NanoFlu also demonstrated a significantly higher geometric mean titers with zero conversion rates in Fluzone Quadrivalent for four drifted H3N2 strains, not included in the vaccine but circulated this year.

We believe this is a validation of NanoFlu's ability to overcome issues related to egg-adaptation and antigenic drift, which are major issues with current vaccines. We look forward to providing additional detail from the study in the near future, including the cell-mediated immunity responses, the T-cell responses, and microneutralization data. We believe these data will differentiate NanoFlu from leading licensed vaccines. NanoFlu has Fast Track status from the FDA and we plan to use the agency's accelerated approval pathway.

We will conduct our required CMC activities in parallel with compiling the immunogenicity and safety portion of our BLA. We will communicate additional timelines once we have finalized our plan. Before I turn the call over to John, a quick update on our ResVax vaccine. We continue to believe in our ResVax vaccine.

We're the only company to have demonstrated potent efficacy in clinical trials in both the older adult population and by vaccinating pregnant women to protect their infants. While not meeting the pre-specified primary endpoints for the Phase 3 trials, we observed that the vaccine had significant effects on hospitalization and pneumonia the volume in both trials, which provides critical insights on the continued need for RSV vaccine. We believe that we can design an affordable pathway to a licensed product over the coming years and are designing new clinical trials that we believe could take us to a licensed product. Now, we have a strengthened balance sheet, we will continue to invest in this program.

Now let me turn the call over to John.

John Trizzino -- Chief Business Officer and Chief Financial Officer

Thanks, Stan. Today, we announced financial results for the first quarter of 2020. For the first quarter, we reported a net loss of $25.9 million or $0.58 per share, compared to a net loss of $43.2 million or $2.11 per share in the first quarter of 2019. The reduction in net loss was mainly due to reduced R&D expenses.

Revenue in the quarter decreased 15% to $3.4 million from $4 million for the same period of 2019, and the decrease was primarily due to the completion of the Prepare trial and 2019 partially offset by revenue reported from CEPI's funding. R&D expenses decreased by 52% to $16.9 million in the first quarter of 2020, compared to $35.5 million in the same period of 2019. This decrease was primarily due to decreased development activities of ResVax, lower employee-related costs and other cost savings due to the Catalent transaction in 2019. G&A expenses increased coming in at $9.4 million in the first quarter of 2020, as compared to $8.7 million for the same period in 2019.

As of March 31, 2020, Novavax had $244.7 million in cash, cash equivalents, and restricted cash. Net cash used in operations for the first quarter of 2020 was $23.1 million, compared to $50.6 million for the same period of 2019. During this quarter, we further strengthened our balance sheet. In the first quarter of 2020, we raised $186 million in net proceeds.

And from April 1 to May 8, we raised an additional $74 million in net proceeds for a total of $260 million since the end of 2019 through our ATM offerings. Novavax's cash position is now in excess of $300 million. That concludes my financial review and I will turn the call back to Stan.

Stan Erck -- President and Chief Executive Officer

Thanks, John. We look forward to updating you on the Phase 1 clinical trial of 2373 in July. And with that, I'll turn it back over to the operator for Q&A.

Questions & Answers:

Operator

[Operator instructions] And I'm showing our first question comes from the line of Michael Higgins with Ladenburg Thalmann.

Michael Higgins -- Ladenburg Thalmann -- Analyst

Thanks operator. Hi, guys. How are you?

Stan Erck -- President and Chief Executive Officer

Great.

Michael Higgins -- Ladenburg Thalmann -- Analyst

Great. Thank you. Congrats with the CEPI funding. That's impressive, especially you have the biggest they have put out so far.

Looking ahead a bit, trying to understand with this ACT accelerator, what kinds of margins you can expect and do you look at anything you're learning from Gilead's Remdesivir and the discussions you are having with the investment community? Thanks.

Stan Erck -- President and Chief Executive Officer

Yes. It's a bit early to predict margins at this point. We do know that we expect to be producing at very large scale and we should be able to have efficient production. We don't know the cost of that production yet.

And nor do we know what the selling price is. So it's a new world out there in the pandemic setting and my expectation is this will have reasonable gross profit operating margins.

Michael Higgins -- Ladenburg Thalmann -- Analyst

The question we will be looking ahead to this summer and just a follow-up from two months to go in the last quarterly call, which is once you've got data in July, you talked a bit about the schematics can come and update as to how you roll into a larger study coming into the fall? Does the I&D stay open? Is it a separate study, separate sites? Obviously, you want to review the data before you can start moving forward, but it sounds like it's happening in a bit of a rolling fashion, can you give us kind of an update on that? Thanks.

Gregory Glenn -- President of Research and Development

Great. So I can jump in. Yes. It will be done under I&D, the data we file to I&D.

And when we see the Phase 1 data, we've written the protocol so that we can pivot rapidly into a later-stage trial. Right now, we anticipate that that will be a Phase 2 trial on the order of 2,000 subjects. However, there is a lot of discussion about how one might accelerate that. So we're doing our best just to be prepared with sufficient animal data and human immunogenicity data to take the next step.

And you'll see, you may have seen we announced that on Wednesday, we're going to give a more detailed update on the COVID preclinical and steps, next steps.

Michael Higgins -- Ladenburg Thalmann -- Analyst

Yes. I noticed that. That's helpful.

Gregory Glenn -- President of Research and Development

OK. Glad you saw that. Yes.

Michael Higgins -- Ladenburg Thalmann -- Analyst

And then the last one. I'm sure it's a busy Q. Just trying to get a sense for the global manufacturing, this is a heck of an update from up to 10 million per month by year end to 100 million by year-end '20, possibly billings next year. I would think it depends not just on the yield that you mentioned on the call, but also securing access to manufacturers.

Obviously, CEPI can help with that, but a lot of the folks that are involved in this data top five globally, they've had a lot of press releases and comments out about securing other manufacturers. How confident can you be that you'll have enough ability to manufacture? Is that's something that CEPI helps with, that WHO helps with, how do we kind of think about that?

Erika Trahan -- Investor and Public Relations

So we did just start thinking about that and so we've been working on it for a while. We have been very optimistic about our data. We've seen this before, we've seen it with two coronaviruses. We've seen in the pandemic flu viruses, we've seen it with Ebola, where we get early clinical data, sorry, early preclinical data and that in mice, that translates into nonhuman primates, that translates into humans and then Phase 1 and Phase 2 trials with the immunogenicity.

We bet. And, of course as you know, we don't have Phase 1 results yet. We bet a while ago that our technology would give us good data in Phase 1. So we didn't wait.

We didn't lose six months by waiting for Phase 1 data. We started on it a right away and are securing sufficient capacity to be able to make the statement that we made in this press release.

Stan Erck -- President and Chief Executive Officer

Appreciate it. Congrats again. Thanks, guys.

Operator

And our next question comes from the line of Mayank Mamtani with B. Riley. Pardon me, Mayank Mamtani, please check your mute button. And our next question comes from the line of Vernon Bernardino with H.C.

Wainwright.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Hi, guys. Thanks for taking my question and congrats on the amazing achievement. I'm very curious and that's because I'm very excited for your very large amount of funding that you got from CEPI. I was wondering if you could tell me what exactly excited them the most as far as the vaccine programs out there to choose your program in particular.

And as far as the candidate concerned, you chose CoV2373, how many candidates did you screen and what led to the choice of that particular candidate for going forward into clinical trials?

Stan Erck -- President and Chief Executive Officer

Thanks for it and I'll answer the first question and let Greg answer the second part of the question. I think what got them most interested in our program was the fact that we are an experienced emerging infectious disease vaccine company, our platform has produced, as I mentioned in my last comment, has produced vaccines that have shown not only good immune responses and safety but efficacy in animal models, nonhuman primary models. We've done in Ebola, we've probably had the best immune responses ever gotten from a vaccine, with our Matrix adjuvant vaccine. So I think it's the experience of that combined with the fact that our process has been scalable.

We've done it with flu. We've done it with RSV. And so we have a lot of confidence we can scale. And I think when you ask how -- when looking across the field and how do they compared to others, I think there are a lot of other good technologies out there that just have not had the experience that we have and so both with the immune responses and with scale.

And so ours just probably represents a fairly safe bet. And the others are exciting and time will tell.

Gregory Glenn -- President of Research and Development

Yes. Hi, Vernon, and thanks for your support.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Hi, Greg.

Gregory Glenn -- President of Research and Development

Let me just jump on this question. I think the hallmark of our vaccine is the immunogenicity. It's very immunogenic and we were able to construct some good assays to demonstrate that and so I think that's good. That was important.

So as you asked, we actually I think out about 30 constructs we made in a short period of time. And we did evaluate them based on several factors, so stability, productivity, because we knew a lot of doses would be required in immunogenicity. I think when we look at our immunogenicity, you may know this on Wednesday, we're going to provide some detail. We have a half-an-hour talk on our COVID program, you'll see our preclinical data.

I think when they saw that that it is very compelling that the vaccine should work and be protective. So I think at that combination immunogenicity, productivity, the stability of the construct, these are proteins that are inherently can be unstable and their structure is really critical. And I think it's a mature technology. We just completed a Phase 3 trial with the same kind of construct.

It's a recombinant nanoparticle Matrix-M, we had very good results there. So I think all those things have come together at this moment. We're very excited and grateful that CEPI stepped up to support us in this magnitude.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Great. I have two follow-ups on that that are related. So one part of the deal is to increase the production of Matrix-M adjuvant. What exactly is that for? And then, Stan, you mentioned that you saw high neutralizing antibodies just after a single dose.

Is part of the thinking and all this such that if you need only a single dose, but you're testing, let's say, V2 to two doses, but because of Matrix-M, the availability of it, allows you to get away with single dose. Does that play into the whole thinking about the one billion doses by the end of 2021?

Stan Erck -- President and Chief Executive Officer

Well, I think I'll let Greg respond.

Gregory Glenn -- President of Research and Development

Yes. First of all, I think we're not seeing real limitation with the adjuvant supply. So our staff has worked very hard to make sure, when you look at those dose numbers, that is not going to be limited by either. So it's a relatively simple process to make Matrix-M.

It's a very good adjuvant. We're going to look at this in the trial setting. As you know that after one dose, we get a very good response. We get neutralizing antibodies.

And we see dose sparing. This is a virus hour, it's highly infectious. It has a very tight binding to the human cell, so disrupting that is going to be very important. And there could be a lot of merits in having really high neutralizing antibody and we're going to weigh all those factors as we move into our late-stage trials.

We'll have the data to look at that and I think we have assays that are really meaningful. They're conservative in terms of neutralization. They're functional in terms of blocking receptor binding. And we think it's gets to the heart of the critical nature of how this infection spreads.

So we're going to take into fact all those factors I think for making the dosing decisions going forward.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Great. Thanks for the question. I have a follow-up. I'll get back to you with other questions or follow up offline.

Thank you.

Operator

[Operator instructions] Our next question comes from the line of Mayank Mamtani with B. Riley.

Mayank Mamtani -- B. Riley FBR -- Analyst

Can you hear me guys now?

Stan Erck -- President and Chief Executive Officer

Yeah.

Gregory Glenn -- President of Research and Development

Yes.

Mayank Mamtani -- B. Riley FBR -- Analyst

Ok. Finally. I got disconnected first. Congrats on the update and thanks again for taking my questions.

Very quickly on the Phase 1 study design. I noticed that you are testing dose without Matrix-M adjuvant. So I'm just curious sort of what's the rationale for that doing with and without Matrix-M? And also as you think about the IgG antibody assessment, just curious how do you think about what you learned from there about other endpoints, the more core endpoints of geometric mean units and others like zero conversion. Could you maybe talk to that?

Gregory Glenn -- President of Research and Development

Yes. That's a great question. So look, whenever you do a trial with an adjuvant with a new compound like this, you need to clearly demonstrate the adjuvant effect. So that really is important and it allows you to compare and contrast the safety in immunogenicity.

With our Ebola vaccine, which I think is a very good blueprint for the immune responses we'll see here, we could see the adjuvant was critical and that was important for going forward for regulators and of course public health and ourselves. So that's its role, it's to demonstrate that the need for the adjuvant. The different measures, they are kind of, if you will, are fogging the looks at the immune response. Over-the over-arching response is a spike response, so we measure the IgG.

Because people are immune naive, we expect to have very high levels of zero conversion on the order of 99%. So that would be the norm here and I think we're going to see that in our adjuvanted, especially our adjuvanted two-dose formulation. The other assays measure different things. So as I mentioned earlier, receptor binding is the first event.

It's an important event. If you can block that, it's very high-affinity events or it takes a really good antibody in our opinion to block that binding. Neutralization is -- there is a different look. It's probably a combination of what you get from receptor binding blocking and some other epitopes, some other immune responses to the rest of the spike protein.

So when we look at all of them, they-as you'll see on Wednesday, when we talk about this, there is a really nice relationship between all those immune measures which makes sense. And I think those different looks at immune response really give us a lot of confidence the vaccine should work.

Mayank Mamtani -- B. Riley FBR -- Analyst

Great. That's super helpful. And then on the Wednesday presentation, I'm assuming this a combination of a nonhuman primate and mice study that you've talked about.

Gregory Glenn -- President of Research and Development

That's correct.

Mayank Mamtani -- B. Riley FBR -- Analyst

Any incremental color you could give on, I think you said 30 constructs you tested in mice. But in the nonhuman primates, was it just one candidate you tested?

Gregory Glenn -- President of Research and Development

Yes. We selected -- by the time, we got to nonhuman primate, we had generated a lot of confidence in the construct we made. So the nonhuman primate is just the 2373 construct.

Mayank Mamtani -- B. Riley FBR -- Analyst

OK. Great. And just final question on NanoFlu, are there any alternative regulatory thoughts that become available, obviously given the current environment, beyond the ones you obviously have like the Fast Track and the accelerated approval that are potential options for NanoFlu?

Gregory Glenn -- President of Research and Development

That's a good -- that's an interesting question. So right now, no, I think we expect to go through accelerated approval. We have an obligation to do a post-licensure efficacy study. I think we're on track for that.

I think it is very, very good data. I think it's intriguing there was a lot of flu when the COVID came around, it was really dominating and it's going to be interesting. I think what COVID will do for flu is we hope to generate interest in preventing this seasonal disease because every year there is a large number of people that die from seasonal influenza and we need a better vaccine. So I think we have very good evidence we have a better vaccine going forward.

And so I think that's going to emphasize this COVID, this pandemic will emphasize the problem we see every year with an annual seasonal influenza vaccine. And the issues we are addressing are the key issues, the fact that vaccines are not able to induce immune responses to recognize these drift strains, and especially around H3N2, so our data looks very strong in that arena. And I think shortly, we're going to be able to show the CMI data and frankly, the Phase 2 data will be published shortly as well. So you'll see that we think that's the missing arm of a good immune response to flu in older adults and I think you'll see our vaccine, I think we've mentioned it before, really gives a very good antigen-specific effector cell response and we think that's an important piece of the puzzle here going forward.

Mayank Mamtani -- B. Riley FBR -- Analyst

Great. I appreciate you taking my questions and look forward to go through the NanoFlu update and then the July update on the Phase 1 study for COVID 19.

Gregory Glenn -- President of Research and Development

Thank you.

Operator

And our next question comes from the line of Vernon Bernardino with H.C. Wainwright.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Hi, guys. Thanks for taking my follow-up. One thing as far as the vaccine is concerned, you probably go into this at the World Vaccine Presentation, what is the actual amount of protein for the CoV2373 candidate that is actually being administered?

Gregory Glenn -- President of Research and Development

Yes. So I think we've mentioned this before, we're using two dose levels in our Phase 1 trial, 25 micrograms and 5 micrograms. It was our experience with Ebola using similar levels that we were really at the top of the dose-response S-curve, so five and 60 in that case micrograms were really no different in terms of immune responses. And so it's our expectation that's likely to be the case here.

So obviously 5 micrograms is very nice dose, wherein 25 micrograms is relatively low, but so we're just doing those two arms, with Matrix and then as you mentioned early on, without an adjuvant as a control. So that's our antigen dose level, 50 micrograms in Matrix, 25 and 5 of the antigens and we'll be giving that with two doses or we also have one arm with the one-dose immunization with 25 and 50 of Matrix.

Vernon Bernardino -- H.C. Wainwright -- Analyst

And as a follow-up, given sometimes the confusion of the symptoms, as far as when you initially look at somebody is infected with SARS-CoV-2 and people who are also infected with the flu, is there a potential to have actually a combination vaccine?

Gregory Glenn -- President of Research and Development

Well, yes, we think about that because our specialty is in registering vaccines, so it's got-it has that potential. I think what we need to see where this will go. Many experts think this will become a common annual seasonal issue and it would make sense to have a combination vaccine. It's certainly theoretically possible.

We could formulate the vaccine, it's the same platform. It's a nanoparticle, our recent Matrix-M in both those settings, that's a good thought.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Because if totally it doesn't go away, conceivably if you added it to a seasonal flu vaccine, then you're kind of taking care of both, and not really relying on the fact of the SARS-CoV-2 ever going away.

Gregory Glenn -- President of Research and Development

Yes. It's a good thought. It's a good thought.

Vernon Bernardino -- H.C. Wainwright -- Analyst

Well, congrats. I look forward to the additional data and really rooting for you guys. So good luck and thanks.

Gregory Glenn -- President of Research and Development

Thanks for your support. Yes. Thanks, Vernon.

Operator

Thank you. And I'm showing no further questions at this time. I will now turn the call back over to CEO, Stan Erck for any further remarks.

Stan Erck -- President and Chief Executive Officer

Yes. Thanks. As you can imagine, we are euphoric in the company. It takes a long time.

We've been working to be at this point for at least a decade that I've been with the company. We've had in the last six weeks, we've worked on a other project that virtually everybody in respiratory vaccines have been trying to do, which is to get a better flu vaccine. Our goal is to get a differentiated flu vaccine, not be as good as the best flu vaccine but differentiated from that and we've accomplished that. And that alone was a big deal.

And then coronavirus comes along and we do what we've been doing for the last half a dozen emerging infectious diseases. And we have a lot of confidence and we're being supported by large groups of academic and non-governmental organizations and I think corporations that will help us get to the point where we can help solve this problem. So we're proud of the work we've done and we're happy we're finally getting recognized for it. And we look forward to reporting data in a fairly short period of time.

And thanks very much for listening in. And at that, I'll sign off.

Operator

[Operator signoff]

Duration: 37 minutes

Call participants:

Erika Trahan -- Investor and Public Relations

Stan Erck -- President and Chief Executive Officer

John Trizzino -- Chief Business Officer and Chief Financial Officer

Michael Higgins -- Ladenburg Thalmann -- Analyst

Gregory Glenn -- President of Research and Development

Vernon Bernardino -- H.C. Wainwright -- Analyst

Mayank Mamtani -- B. Riley FBR -- Analyst

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