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IMV Inc. (NASDAQ:IMV)
Q1 2021 Earnings Call
May 12, 2021, 8:00 a.m. ET

Contents:

  • Prepared Remarks
  • Questions and Answers
  • Call Participants

Prepared Remarks:


Operator

Good morning, and thank you for standing by. Welcome to the IMV Inc. first-quarter 2021 conference call. [Operator instructions] I would now like to hand the conference over to Pierre Labbé, chief financial officer.

Thank you. Please go ahead.

Pierre Labbe -- Chief Financial Officer

Thank you, Takke. Good morning, everyone. My name is Pierre Labbé, CFO at IMV, and I'm pleased to welcome you to our clinical and operational update and first-quarter financial results conference call. I'm joined today by Fred Ors, our chief executive officer; and Andrew Hall, our chief business officer, who will be available for the question-and-answer period at the end of the call.

Fred will begin with an overview of the company's operational highlights, and Andrew will follow with comments about the clinical programs. I will conclude with the financial summary of the quarter. During this call, we will discuss our business outlook and make forward-looking statements. Any forward-looking statements made today are pursuant to and within the meaning of the safe harbor provisions of applicable securities laws.

These comments are based on current expectations of management regarding future events and operating performance. They are not guarantees of future performance or results. All forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks are discussed in our continuous disclosure documents filed in compliance with applicable securities law.

The press release, the MD&A and the financial statements are all posted on our website at imv-inc.com. If you wish to receive a copy of these documents, please do not hesitate to contact us. Finally, take note that we will take questions only from sell-side analysts. I will now turn the call over to Fred.

Fred?

Fred Ors -- Chief Executive Officer

Thank you, Pierre. Good morning, everyone, and welcome. I am very pleased today to have the opportunity to review our progress in the first quarter, including important milestone in our cancer T cell therapy program. Our clinical programs continue to progress according to plan, including the initiation of our Phase II relapsed/refractory DLBCL study in combination with Merck's Keytruda.

With respect to this important study, we completed regulatory filings, and we have started enrolling clinical sites in the U.S. and Canada and are expanding into other countries. At the same time, we continue to expand the footprint of Maveropepimut-S beyond the current ongoing trials in solid and hematological malignancies. Earlier this week, we announced a new investigator-initiated study in breast cancer, which we plan to initiate in the first quarter of this year.

Andrew will provide further details about this study later in the call, but I want to share the enthusiasm that we have about this study. First of all, survivin has been identified by investigators at Providence Cancer Institute in Portland, Oregon, has a biomarker of resistance to treatment in this patient population. This discovery is giving us the opportunity for the first time to test our survivin-targeted T cell therapy in an earlier line of treatment. It is also a neoadjuvant study, providing a unique opportunity to access complete tumor resection after surgery and thus demonstrate the in vivo response to our therapy.

We believe that both the level of information and demonstration that can come out of this study has the potential to create significant value for our platform and our shareholders. We are also on track to initiate in the second half of the year, a Phase I study in non-muscle-invasive bladder cancer through a collaboration with the Research Center of University Laval in Québec City. This study is sponsored by IMV and will be partly funded by government grants. In this study, which is also in an earlier line of treatment, we will be targeting MAGE protein family member, A9 and survivin.

Both has been associated with the biology of bladder cancer and a poorer prognosis. This is an exciting milestone for the company as this is the first-in-human trial for our second immunotherapy, DPX-SurMAGE. This trial has the potential to further demonstrate the receptivity of our platform and its ability to generate targeted T cell therapies for various indications. Andrew will also give more detail about this dual-targeted immunotherapy later in the presentation.

Before I turn the conference to Andrew, I wish to welcome to IMV, two exceptional new board members. Mr. Kyle Kuvalanka and Dr. Michael Kalos.

Following the recent departure of Wayne Pisano and the announced retirement of James Hall following this year's annual meeting. I'd like to take this opportunity to thank both of them, Wayne and James for their dedications and guidance throughout the years and wish them the very best going forward. Mr. Kyle Kuvalanka, currently serves as chief financial officer and chief operating officer at Goldfinch Bio, a precision medicine company.

Kyle brings over 20 years of experience as a senior leader in the biopharmaceutical industry with a successful track record in forming and negotiating strategic collaborations, leading financings, including the IPO of Blueprint Medicine, as well as building and directing business and finance functions. I also want to welcome Dr. Michael Kalos, a pioneer and internationally recognized expert in T cell therapy and immunotherapy, who brings over 25 years of experience across cell therapy and immuno-oncology in global organizations such as Janssen and Eli Lilly. The laboratory he founded and directed at the University of Pennsylvania played a key role in the success of the cell therapy program at Penn, including the clinical development that led to the approval of Kymriah, the first-ever FDA-approved CAR-T cell therapy.

Finally, a management update today, Dr. Joanne Schindler, gave her resignation for personal reasons effective June 11, 2021. Over the next week, Joanne will transition responsibilities, while remaining in her role as chief medical officer, and we are actively working with our recruitment firm to hire a new chief medical officer, who will drive Maveropepimut as toward registration. In the meantime, our clinical and regulatory teams will continue to execute and keep on track of our development program.

We thank Joanne for her contribution during her tenure and wish her the very best. This concludes my opening remarks, and I will now turn the conference over to Andrew for a more detailed review of our clinical program.

Andrew Hall -- Chief Business and Commercial Officer

Thank you, Fred. Good morning, everyone. Before I get into the specifics, I'd like to emphasize, as illustrated on Slide 6, the steady progress IMV has made, expanding the clinical footprint supporting the broad utility of Maveropepimut-S. I'm also excited to present for the first time our second clinical asset, DPX-SurMAGE, a dual-targeted T cell therapy that will be first investigated in bladder cancer.

Looking ahead, we now have clear path to market for Maveropepimut-S in DLBCL and compelling data in many indications with multiple pending catalysts set to occur over the next 12 months. I would like to remind you all the clinical success demonstrated with Maveropepimut-S is supported by the outstanding value proposition behind IMV's novel DPX platform. This technology has enabled the demonstration of efficacy through a unique and potentially synergistic with other mechanism -- with other immunotherapies that is well tolerated, easy to administer, and importantly, cost-effective to manufacture. It also supports DPX-SurMAGE, and we are exploring its application for other non-peptide therapeutic targets.

With that said, I will now review the progress of our oncology programs, starting on Slide 9 with relapsed/refractory DLBCL. As Fred mentioned, we filed our investigational new drug application with the FDA and the clinical trial application to Health Canada in parallel to support the initiation of the Phase IIb study. Considering the typical procedures and potential questions regulators may ask prior to approval, we anticipate the trial to be initiated toward the end of quarter two this year. This trial will first involve U.S.

and Canadian sites and then expand to Europe and Australia later this year. Our strategy here is to move as quickly as possible for this trial and to activate as many sites as necessary to ensure rapid recruitment. We know the space is competitive, although from initial conversations with prospective clinical sites, we are confident that the differentiation of Maveropepimut-S and Keytruda will drive timely enrollment. As a reminder, this trial is a three arm, randomized, parallel group, Simon two-stage study designed to assess the combination of Maveropepimut-S and Keytruda with and without cyclophosphamide.

With a third arm to evaluate Maveropepimut-S as a single agent. Across the three arms of this study, IMV's lead compound will be evaluated in up to 150 patients with relapsed or refractory DLBCL who have received at least two prior lines of systemic therapy and who have failed autologous stem cell transplant or CAR-T therapy. The primary endpoint of the study is the objective response rate centrally evaluated per Lugano 2014 criteria and measured by the number of subjects achieving a best response of partial or complete response during the two year treatment period. All subjects will be evaluated for their baseline PD-L1 expression, so to validate the exceptional SPiReL data we reported this year -- or last year, I should apologize, that highlighted PD-L1 as a predictive biomarker for clinical success.

By the current time line, we anticipate dosing our first patient shortly and look forward to presenting an interim clinical analysis for this trial early in 2022. I will now briefly discuss our plans in recurrent ovarian cancer on Slide 10. As previously communicated, biomarker analyses are ongoing from the tissue collected in the DeCidE trial and are expected to be completed this quarter. The goal here is to better understand the treatment activity and potential predictive biomarkers in this population to help inform the next stage of development.

With the balance and efficacy -- sorry, with the balance of efficacy and tolerability demonstrated with Maveropepimut-S in patients with ovarian cancer, use early in the treatment regimen is a natural fit. As a trial in this population will be larger and longer, the ability to predict response is really important. Once the analysis is completed, we will request a meeting with the FDA in the second half of this year to finalize the design of the next trial. We will also present the analysis of the translational data set in an upcoming scientific conference.

Before discussing the new investigator-initiated study in breast cancer, I'll quickly mention that there's no material update to provide with respect to the Basket Trial. As a demonstration of our expanded footprint in oncology and the potential of our lead immunotherapy, we announced earlier this week that Maveropepimut-S will be investigated in patients with hormone receptor positive/HER2-negative breast cancer. I would like to remind you this population includes nearly 70% of all patients with breast cancer and the unmet need remains high considering the well-understood poor response to neoadjuvant endocrine treatment. This investigator-initiated Phase Ib study will be conducted at the Providence Cancer Institute in Portland in Oregon and is expected to begin later this summer.

The trial is a three-arm investigation of Maveropepimut in combination with an aromatase inhibitor with and without radiotherapy or cyclophosphamide prior to surgery. Across the three arms of the study, Maveropepimut-S will be evaluated in 18 subjects with resectable, non-metastatic hormone receptor positive HER2-negative breast cancer. The primary objective is to evaluate the safety of the neoadjuvant combination. The study will also examine the tumor microenvironment in detail to validate the therapeutic hypothesis that survivin-specific T cells are driving the efficacy of Maveropepimut-S in solid tumors.

As such, this study will also include an extensive translation analysis of collective tissue and serum to identify markers of activity in the tumor and within the tumor microenvironment. We're particularly enthusiastic about the therapeutic potential of Maveropepimut-S in breast cancer. As Fred mentioned, we know that survivin expression is positively correlated with negative outcomes in this tumor type. Not only will this trial deepen our understanding of both Maveropepimut-S and the DPX platform in a new and different population of patients, but it will also identify markers that may derisk future clinical studies in other solid tumors with high survivin expression.

Moving on to Slide 12. I'd like to briefly introduce our second clinical product, DPX-SurMAGE, a dual-targeted T cell therapy. This product combines the DPX platform in two types of cancer antigens, survivin and MAGE-A9. MAGE-A9 is a member of the mage protein family, which is frequently expressed in human cancers, including bladder, lung and kidney.

Selected peptides of MAGE-A9 will be formulated with selected peptides from the survivin protein and the DPX platform to form a new and dual-targeted T cell activating therapy, DPX-SurMAGE. Dr. Fradet, and his team have successfully completed preclinical evaluations, and we are really excited to move this important therapy into clinic. Our first investigation of DPX-SurMAGE will be as monotherapy in patients with non-muscle invasive bladder cancer and in combination with a checkpoint inhibitor in muscle-invasive bladder cancer.

This IMV sponsored trial will be led by Dr. Yves Fradet and his team. Dr. Fradet is a professor of surgery and researcher in cancer immunotherapy at the Hospital Research Center at Laval University in Québec City.

The first study will evaluate DPX-SurMAGE with and without cyclophosphamide prior to transurethral resection of recurrent low-grade or high-grade non-muscle invasive bladder cancer and is scheduled to be initiated in the second half of this year. The second study, which will be initiated sequentially, will evaluate DPX-SurMAGE and an anti-PD-1 for the treatment of muscle-invasive bladder cancer prior to and following cystectomy. Before turning the conference back to Pierre for a review of the quarter's financials, I'll quickly mention that there is no material update to provide with respect to the COVID-19 program in this quarter. Pierre, I'll pass the conference back to you.

Pierre Labbe -- Chief Financial Officer

Thanks, Andrew. Before I get into the financial, I want to underline a change in our accounting policy. Effective January 1st, 2021, we adopted the U.S. dollar as our functional and presentation currency.

Prior to this date, the functional and presentation currency was the Canadian dollar. The change in the functional currency from the Canadian dollar to the U.S. dollar was made to more closely reflect the primary economic environment in which we currently operate. The change in functional currency was applied prospectively.

For the change in presentation currency, it was applied retrospectively, and therefore, the financial statements are presented in U.S. dollars, together with the comparative information as of December 31st, 2020, and for the three-month period ended March 31st, 2020. You can find more information on this change in Note 2 of the financial statements for the three-month period ended March 31st, 2021. Now back to the financials.

For the three months period ended March 31st, 2021, R&D expenses were 4.7 million compared to 5.1 million for the same period last year. The decrease of $400,000 was mainly due to a decrease in expense related to the ongoing Basket Trial and also the timing of manufacturing activities for DPX-Survivac and DPX-SurMAGE. It was partly offset by an increase in personnel costs due to an increase in headcount and expenses related to the preclinical development of the DPX-COVID-19. The Government assistance totaled 1.2 million for the three months period ended March 31st, 2021 compared to $400,000 in Q1 2020.

This increase is mainly explained by government grants from the Canadian government for the development of DPX-COVID-19. The G&A expenses increased to 3.2 million from 2.3 million last year. And this is explained entirely by an increase of $900,000 in insurance premium. The net loss and comprehensive loss was 7 million or $0.10 per share for the quarter compared to 7.2 million or $0.14 per share for the same period last year.

As of March 31st, 2021, the company had cash and cash equivalents of 30.5 million compared to 36.3 million at the end of 2020. For the purpose of assessing the corporation as a going concern, although it is difficult to predict funding requirements based on the current operational plan, it is anticipated that existing cash and cash equivalents and identified potential sources of cash will fund operations and capital expenditure requirements until the first quarter of 2022. These estimates are based on assumptions and plans which may change and which could impact the magnitude and/or the timing of operating expenses, capex and the corporation's cash balance. It also does not take into account any use of the ATM that we have in place or any other potential non-dilutive funding.

Cash and cash equivalent decreased by 5.8 million in the first quarter of 2021. We used $7.8 million of cash in operating activities and 0.4 million in investing activities. Financing activities generated $2 million and effect of foreign exchange on cash generated 0.1 million. The cash generated by financing activities come from our at-the-market facility for gross proceeds of $2.3 million.

As of May 11, 2021, the number of issued and outstanding common shares was 67.8 million and a total of 5.1 million stock options, DSUs and warrants were outstanding. Finally, take note that the corporation's financial statements for the three months period ended March 31st, 2021, and the related MD&A are available on SEDAR, on EDGAR and on the company's website. Thanks for your attention. And I will now turn the call back over to Fred for his closing comments before the Q&A session.

Fred?

Fred Ors -- Chief Executive Officer

Thanks, Pierre. Our presentation today should give you a good indication of the significant recent progress we have made expanding the footprint of Maveropepimut-S in new indications and broadening our pipeline toward new targeted T cell therapies. At the same time, we are able to attract new and high-quality board members that would provide valuable guidance on advancing IMV to the next level on our path from a clinical-stage company today to a successful pharma tomorrow. As we continue making progress in our quest to deliver improved outcomes for patients, we are also grateful for the continued support of all our dedicated employees, stakeholders, partners and shareholders.

Thank you for your attention. Operator, we are now ready to take questions.

Questions & Answers:


Operator

[Operator instructions] Your first question comes from the line of Tom Shrader of BTIG. Please go ahead. Your line is open.

Kaveri Pohlman -- BTIG -- Analyst

Hi, this is Kaveri for Tom. Thanks for taking our question. I just have one. Can you talk about your rationale for selecting HR-positive/HER2-negative breast cancer? There aren't a lot of immunotherapies approved in this setting, and patients seem to respond well to therapies like CDK inhibitors and SERD.

Fred Ors -- Chief Executive Officer

Thanks for your question. This is Fred here. I'll start and turn -- and maybe Andrew can complete. So it's really -- the investigators that found us, found our survivin T cell therapy because they have, like Andrew was explaining, identified that in the neoadjuvant setting, so it's really in the neoadjuvant setting first, the rate of response of the drugs that are currently being used is quite low, I'd say 10%.

But when you are looking at those nonresponders, which is the majority of women being treated at neoadjuvant stage, and you look at what could be the potential reasons for that, they found out that survivin was one of the most upregulated biomarker for resistant to this treatment. So they found us, really, we didn't found them. But what we like very much about it, and you've heard us saying this many times, we believe that there are two things that are important for making T cell therapy work is. The first one is creating a meaningful dose of T cells in the blood of patients, so controlling the pharmacokinetic, which we are doing with our platform, DPX.

And the second thing is targeting something in cancer that is really associated with the biology of cancer, something that plays a role in the evolution of cancer or resistance to treatment. And this is really the perfect case here for us, not only we have all of this, but it's also in much earlier line of setting in a neoadjuvant setting where it's probably the best place for immunotherapy to be. And at the same time, the bar is quite low, again, in the neoadjuvant setting. I don't know, Andrew, if you want to add more on this.

Andrew Hall -- Chief Business and Commercial Officer

Yes. I'll just add a little flavor. And I think it's important to recognize as a sort of a strategic driver for IMV now that the idea of following the biology with the high expression of survivin in this population that appears to be more consistent to treatment is a really compelling reason to go into this population. I mean, commercially, it is the largest point in breast -- the largest-sized population in breast cancer, and it's obviously very appealing for the reasons that Fred mentioned with respect to earlier lines of treatment and a more immune enabled population and potentially a more available population as we understand that that late-line in breast cancer is very competitive.

But this idea of following the biology in a population where we'll be able to collect tissue to do analysis and then maybe identify other solids that we can follow behind that is a really exciting step forward for this technology. And importantly, as we're now creating other therapeutics with other therapeutic targets, we may start to find an improved rationale for even further expansion of the IMV footprint beyond what we're showing with Maveropepimut. So it's an excellent question, and I think the observation that we're following of biology is important to reiterate.

Kaveri Pohlman -- BTIG -- Analyst

Great. Thank you and congrats on the progress.

Fred Ors -- Chief Executive Officer

Thank you.

Operator

Your next question comes from Joe Pantginis of H.C. Wainwright. Please go ahead. Your line is open.

Joe Pantginis -- H.C. Wainwright -- Analyst

Hey guys. Good morning and thanks for taking the question. And sad to see Joanne go, and good luck in your next steps. So just continuing in the breast cancer vein here, I wanted to just continue on talking about benchmarking.

So first, with regard to the upcoming study, I know you talked about broadly the inclusion criteria, but what stages of diseases are the patients going to be? And then let me know if this is a fair statement since you talked about response rates being essentially under 10%. Is it fair then that any responses that you see above that, based on the translational analyses that you'll be conducting, could certainly implicate a role for the immunotherapy? And what would you consider to be a meaningful improvement of responses at this point?

Fred Ors -- Chief Executive Officer

Thank you, Joe. It's -- like we said, it's a very early line of setting where women are typically treated with neoadjuvant aromatase inhibitors and sometimes given neoadjuvant chemotherapy, depending on some specific analysis of the state of the tumor. And basically, you don't see a lot of tumor downstaging or reduction, but it can certainly provide some benefits before the surgery. So that's really where this is used and has limited benefit other than, like, I was just saying for surgery.

And so to answer your question, yes, we -- the premise of immunotherapy, as you know, is the potential to early create an immune activation or immune response in patients would like -- who could improve the long-term outcomes of patients. And that's why we like to be really at this line, because that's where immunotherapy can really make a difference what we like. And thanks for asking the question two is that, yes, we will be able to see the activity of the T cell therapy on the tumors. We will be able to see the impact between the start of treatment and surgery and see if T cell therapy can really make a bigger difference than what is currently used for neoadjuvant.

Joe Pantginis -- H.C. Wainwright -- Analyst

And if I could just shift gears for a second. I'll admit, maybe I'm just watching the news too much and just talking about manufacturing and everyone's just so concerned about different supply chains in the United States or what have you and across the world. So you, obviously, have made the case about very low-cost manufacturing for your assets, and that's very encouraging, especially when you compare against other types of immunotherapies or cellular therapies. So with that said, what could you consider any sort of rate rate-limiting steps with regard to the manufacturing process that anyone might be concerned about or shouldn't be concerned about, even if it's like sourcing the peptides or anything external that might cause potential concern if there's ever any supply chain issues?

Fred Ors -- Chief Executive Officer

Well, first of all, I have to say that luckily, and we are not experiencing any supply chain issues related to manufacturing and the reason is that the technology, we -- the drug delivery technology, we are developing is, it's a lipid bit nanoparticle technology, but the composition and the way it's manufactured is quite different from what is the source of supply chain issues in the world, which are with LNP technologies for mRNA vaccine. So if you think about the lipid composition, it's different, all the elements that we're using are different with -- as you know, it was invented by the company, and we own a very strong IP portfolio on this platform. And to my knowledge, we are the only one in the world at this time, developing a platform like this. So it protects us from those supply chain issues.

On the peptide side of things, again, the peptide vaccines are the next generation of vaccine, I would say, there's not a lot of peptide vaccines currently in development. So we don't suffer any supply chain issues related to peptide manufacturing. There's more than 100 peptides approved by the FDA, a lot of capacity in the world. So we don't foresee that in the future it's going to be a limiting factor for manufacturing.

Joe Pantginis -- H.C. Wainwright -- Analyst

Got it. Fred, I really appreciate that color. Thanks a lot.

Fred Ors -- Chief Executive Officer

Thanks.

Operator

[Operator instructions] Your next question comes from Ted Tenthoff of Piper Sandler. Please go ahead. Your line is open.

Ted Tenthoff -- Piper Sandler -- Analyst

Great, thanks guys and thanks for all the updates on all the progress. I wanted to ask about the IIb study of Maveropepimut and Keytruda in DLBCL. And again, sort of to get a better understanding of what you think the contribution of the low dose cyclophosphamide is. And I know that in that study, you have the single-arm Maveropepimut.

If that ends up showing that cyclophosphamide is not really adding anything, would it be removed from other studies? And kind of how do you see cyclophosphamide fitting into the future there? Will that all be data driven? And are there differences between DLBCL maybe in the other indications?

Fred Ors -- Chief Executive Officer

Thanks, Ted. So first answer -- first part of the answer is, yes, we are testing the contribution of CPA in the design of the study. If we see contribution, we're going to keep low dose CPA in the treatment. It's a drug that's available.

The safety profile is good. So it won't be a problem. If it doesn't show any meaningful benefit, then we'll simply remove it and we'll just keep Maveropepimut-S and Keytruda as a combination. Whether -- there is a lot of preclinical science around the use of cyclophosphamide with other immunotherapeutic agents.

However, we are the first to generate T cell therapy activity in -- with this technology in DLBCL. So I believe that confirmation in human is really what should be the base for the decision, and that's what we are doing. Either way, there's going to be a path to market for the combination. Will this translate into the same thing in other indications? It's certainly something we're going to be looking at.

But at the same time, like you said, there are important differences in the tumor microenvironment, for example, between, let's say, DLBCL and ovarian cancer. And that's where a metronomic dose of chemotherapy can really help the T cells access the tumor, and it might not be the case in DLBCL. But, for example, it could be the case in ovarian. So we really want to base the decision on clinical data as we move forward for CPA.

Ted Tenthoff -- Piper Sandler -- Analyst

Got it. OK, cool, awesome. I appreciate. I'm really excited to see the more data coming this year.

Fred Ors -- Chief Executive Officer

Thank you, Ted.

Operator

Your next question comes from Chelsea Stellick of iA Capital Markets. Please go ahead. Your line is open.

Chelsea Stellick -- iA Capital Markets -- Analyst

Hi, good morning. I just have one or two quick questions just on the finance side. So, I guess, although the 30 million is sort of enough to fund operations through till the first quarter of 2022. I just kind of want to gauge further appetite in accessing the ATM again? And if so, what the use of funds would be? I guess I'm just trying to get more clarity and specificity on future funding or funding for future operations.

Fred Ors -- Chief Executive Officer

Pierre, do you want to take that one?

Pierre Labbe -- Chief Financial Officer

Yes. Sure. Thanks, Chelsea. Yes, for the use of the ATM, I think we don't have any specific plan to use it.

It's a tool that is there that we can have access to if we believe that it makes sense for the company in terms of share price and things like that. So -- and that's how we used it in the past. So there is no guarantee that we will use the ATM in the next 12 months. So just wanted to mention that in the cash that we have and in the duration of the cash, we don't take into account any use of the ATM, but it doesn't mean that we will use it in the next few months.

Fred Ors -- Chief Executive Officer

Maybe, Andrew, yes, sorry, I don't know Andrew if you want to add on the BD activities, too, that we are doing with the platform? Andrew?

Andrew Hall -- Chief Business and Commercial Officer

Sorry was on mute. Yes, I was in the office. To make very clear, we have a healthy appetite for mechanisms that are non-dilutive in our funding as well. And I'm encouraged by the progress we're making in those discussions.

I think for a company that is our size, we need to remain open to sort of the possibility of creating business development momentum. And as we create more therapeutic opportunities in our pipeline by sort of leaning into our technology as perhaps a drug delivery mechanism to create opportunities for other mechanisms that are maybe not peptide targets, we do start to open a revenue stream for non-dilutive opportunities through business development that is complementary to anything we will do through either an ATM or through other fundraising mechanisms. And it's an important element to balance the value of IMV in the midterm and the long term via an ultimate funding mechanism.

Chelsea Stellick -- iA Capital Markets -- Analyst

I guess just one more question from me. With the growing head count, what can we sort of expect for G&A over the next year?

Pierre Labbe -- Chief Financial Officer

Yes. For the G&A, we don't expect an increase in terms of head count and costs related to the G&A because, as I mentioned, the increase that we saw in the first quarter was directly related to an increase in insurance premium that we have in June of 2020. So nothing related to the addition of more people in G&A.

Chelsea Stellick -- iA Capital Markets -- Analyst

Thank you, that's all for me and I'm looking forward to sort of the second half of the year where there's quite a few catalyst events. Thank you.

Operator

There are no further questions at this time. I will turn the call over to Fred Ors for closing remarks.

Fred Ors -- Chief Executive Officer

Well, thank you very much, everyone for your time this morning and all the good questions, and have a good rest of the day.

Operator

[Operator signoff]

Duration: 40 minutes

Call participants:

Pierre Labbe -- Chief Financial Officer

Fred Ors -- Chief Executive Officer

Andrew Hall -- Chief Business and Commercial Officer

Pierre Labb -- Chief Financial Officer

Kaveri Pohlman -- BTIG -- Analyst

Joe Pantginis -- H.C. Wainwright -- Analyst

Ted Tenthoff -- Piper Sandler -- Analyst

Chelsea Stellick -- iA Capital Markets -- Analyst

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