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What happened

After announcing the acquisition of the privately held Kolltan and reporting third-quarter financials, shares in Celldex Therapeutics (NASDAQ:CLDX) jumped 22% last month, according to S&P Global Market Intelligence.

So what

Acquiring Kolltan nets Celldex a pipeline of early stage biologics targeting receptor tyrosine kinases that Celldex believes complements its existing drug development plans.

Among the interesting biologics Celldex is acquiring are KTN0158, a monoclonal antibody that inhibitors KIT activation and receptor dimerization in tumor cells and mast cells, and KTN3379, a monoclonal antibody designed to block the activity of ErbB3 (HER3). KTN0158 is currently in a Phase 1 dose escalation study in refractory gastrointestinal stromal tumors, and KTN3379 recently completed a Phase 1b study for use alongside Erbitux in refractory head and neck squamous cell carcinoma and BRAF-mutant non-small cell lung cancer.

Celldex also updated investors on its financials and clinical trial progress early last month.

The company's third-quarter operating expenses were $32.2 million and its net loss was roughly $30 million. Celldex finished September with $203 million in cash and equivalents, down from $220 million in June, and $16.2 million in long-term liabilities. Management expects that cash on hand and money that can be raised via an existing stock issue plan can fund operations through 2018.

Celldex's lead product candidate, glembatumumab vedotin, continues to enroll patients with metastatic triple negative breast cancer over-expressing gpNMB in a phase 2b study. Management reports enrollment in this trial has accelerated and they expect to provide an updated target for completing trial enrollment early next year.

Management also reminded investors that they had reported data from a phase 2 study of glemba in checkpoint-refractory metastatic melanoma last quarter. The study met its primary overall response endpoint, and they're now enrolling patients to evaluate glemba in combination with other therapies, including Celldex's varlilumab and commonly prescribed checkpoint inhibitors.

Now what

Celldex's investors took a big hit earlier this year when Rintega failed in a phase 3 brain cancer trial. Now, shares could be finding their footing as investors model for opportunities associated with other potential treatments that are making their way through Celldex's pipeline.

Celldex's firm financial footing, and the potential for pipeline data over the next year or two, makes this stock intriguing. However, Celldex's focus is on oncology, and historically, 93% of cancer trials fail in clinical studies. Therefore, Celldex is a high risk/high reward stock that's best left to aggressive investors able to withstand additional future trial failures.

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