Please ensure Javascript is enabled for purposes of website accessibility

Why You're Smart to Buy Cara Therapeutics Stock

By Keith Speights - May 12, 2017 at 2:42PM

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

Don't worry about the recent pullback in Cara Therapeutics' share price. Here's why the stock remains a buy.

Cara Therapeutics (CARA 4.83%) isn't profitable and probably won't be for quite a while. The company lost over $27 million in the first quarter. It doesn't have a product on the market yet. Cara's stock is down by a double-digit percentage in just the last month. 

But Wall Street analysts think that Care Therapeutics shares are poised to more than double over the next 12 months. I wouldn't be surprised if their price targets prove to be relatively accurate. if you have recently bought or are planning to buy shares of Cara Therapeutics, you're pretty smart. Here's why.  

Man with light bulb drawings in background

Image source: Getty Images.

Bad news is good news

First, let's look at Cara's stock pullback over the last month or so. This is a textbook example of bad news now representing good news for the future. 

The reason why Cara's stock price fell was that the company sold more than 5.1 million shares through a public offering. That's bad for current shareholders, because the move diluted the value of their shares. But it's good news for anyone who recently purchased the stock or plan to do so soon.

Cara raised $86.5 million in net proceeds from the stock offering. This puts the biotech in solid financial position. Cara estimates that its cash position should allow it to fund operations into 2019. Investors who buy the stock now probably won't be at risk for further dilution for a long time to come. 

Multiple catalysts ahead

There are several potential catalysts for Cara Therapeutics stock coming up soon. The company will announce top-line data from its phase 2b study of oral CR845 in treating chronic pain associated with osteoarthritis. Cara also plans to report results from an interim conditional power analysis from a phase 3 study evaluating intravenous CR845 in treating post-operative pain.

On top of these two updates, it expects to get data from a pharmacokinetic safety trial of multiple doses of oral CR845 in hemodialysis patients. This data will help Cara define bioequivalent tablet strengths as part of its effort to develop an oral tablet formulation for moderate to severe uremic pruritus (itching caused by chronic kidney disease).

What's great for investors buying Cara stock now is that all of these catalysts will occur within the next seven weeks. Of course, if the results aren't positive, one or more of these updates could bring the stock down. There's reason for optimism, though. CR845 has looked good in previous clinical studies. 

Tremendous opportunity

It's not hard to see why investors get excited about the prospects for CR845. There has been much attention given to the opioid abuse problems in the U.S. Although opioid drugs are great at alleviating pain, they're also highly addictive. These addictive qualities can make healthcare professionals hesitant to prescribe the drugs and patients reluctant to take them. CR845 could present an appealing alternative.

Although CR845 is an opioid, it's quite different from the ones getting the negative publicity. Morphine, oxycodone, and hydrocodone bind to mu opioid receptors in the body's central nervous system. CR845, however, doesn't enter the brain like these drugs do. Instead, it targets kappa opioid receptors in peripheral nerve cells outside of the central nervous system. What that means is that CR845 can relieve pain without being addictive or having some of the other adverse effects of commonly used opioid drugs.


Image source: Getty Images.

The potential market is huge. Over 200 million prescriptions are filled each year for drugs to manage pain outside of the hospital setting. Another 100 million prescriptions are filled annually for managing chronic pain. Over 20 million Americans take prescription drugs for treating uremic pruritus.

If the clinical studies evaluating CR845 go as well as Cara hopes they will, the stock should soar. 


There are risks, however. It's possible that problems could arise in one or more of the CR845 studies. Cara has already had a study put on clinical hold by the U.S. Food and Drug Administration (FDA) because of potential safety concerns. (The hold was lifted later.) Even if clinical testing doesn't hit any snags, the FDA could find a reason to reject approval of the drug.

And there could be significant competition. Trevena (TRVN 7.26%) announced positive results from two late-stage studies of Olinvo in February. While Olinvo is a mu opioid drug like morphine, oxycodone, and hydrocodone, it selectively activates pain-relieving pathways and avoids the pathway associated with the adverse effects typically experienced with these other opioid drugs.

Trevena plans to submit Olinvo for FDA approval in treating moderate to severe pain in the fourth quarter of 2017. If the FDA gives the green light to the drug, Olinvo will beat CR845 to market.

Smart move

My colleague Sean Williams recently listed Cara Therapeutics as one of four marijuana stocks he thinks have a shot at reaching billion-dollar market caps. (Cara has a cannabinoid drug in pre-clinical development, which qualifies it as a marijuana stock of sorts.) I think Sean could be right. 

Cara has risks, but the potential rewards outweigh the risks in my view. Buying now could turn out to be a smart move.

Keith Speights has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Invest Smarter with The Motley Fool

Join Over 1 Million Premium Members Receiving…

  • New Stock Picks Each Month
  • Detailed Analysis of Companies
  • Model Portfolios
  • Live Streaming During Market Hours
  • And Much More
Get Started Now

Stocks Mentioned

Cara Therapeutics, Inc. Stock Quote
Cara Therapeutics, Inc.
$12.38 (4.83%) $0.57
Trevena, Inc. Stock Quote
Trevena, Inc.
$0.23 (7.26%) $0.02

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

Related Articles

Motley Fool Returns

Motley Fool Stock Advisor

Market-beating stocks from our award-winning analyst team.

Stock Advisor Returns
S&P 500 Returns

Calculated by average return of all stock recommendations since inception of the Stock Advisor service in February of 2002. Returns as of 08/10/2022.

Discounted offers are only available to new members. Stock Advisor list price is $199 per year.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.