Please ensure Javascript is enabled for purposes of website accessibility

Here's Why Assembly Biosciences Jumped Again on Thursday

By Cory Renauer - Oct 17, 2019 at 5:38PM

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

Investors digesting a late-breaking data drop pushed up the stock.

What happened

Shares of Assembly Biosciences (ASMB 0.46%), a clinical-stage biopharmaceutical company, jumped for the second day in a row. There was a lot to unpack in a pair of abstracts released on Wednesday that will accompany a late-breaking poster presentation at the American Association for the Study of Liver Diseases (AASLD) annual meeting next month.

Investors thrilled with signs of success for the company's experimental hepatitis B therapies ABI-H0731 and ABI-H2158 drove the biotech stock 21% higher on Thursday and 61.7% higher over the past two trading sessions.

So what 

There still aren't any cures available for around 250 million people infected with the hepatitis B virus (HBV), and Assembly Biosciences was beaten up earlier this year for not delivering on a promise to completely cure the virus with ABI-H0731. The stock is still worth far less than it was a year ago, but investors have come around to the idea that a new standard antiviral treatment that almost cures HBV is still worth a great deal.

Hand drawing an upward sloping chart.

Image source: Getty Images.

There's still a pretty good chance that a functional HBV cure will emerge from Assembly's pipeline. Follow-up results for ABI-H0731 plus Baraclude look good enough to take patients off the combination treatment next year to see if patients start showing signs of the infection in the long term.

Investors were even more impressed with the first look at the company's next-generation HBV core inhibitor, ABI-H2158. The first dose in an ascending dose study with ABI-H2158 as a monotherapy led to steep declines in signs of HBV infection after just 14 days of treatment.

Now what

If either of Assembly's HBV drugs becomes modestly successful, this company's recent $381 million market cap will more than double, more than once. We'll get a clearer picture when the company describes its poster presentations at AASLD on Monday, Nov. 11, 2019.

After burning through $46 million in the first half of 2019, the company finished June with $174 million in cash and securities. That's only enough to fund the company's expanding operations into the beginning of 2021, which means a dilutive secondary offering is probably right around the corner.

Cory Renauer has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Invest Smarter with The Motley Fool

Join Over 1 Million Premium Members Receiving…

  • New Stock Picks Each Month
  • Detailed Analysis of Companies
  • Model Portfolios
  • Live Streaming During Market Hours
  • And Much More
Get Started Now

Stocks Mentioned

Assembly Biosciences, Inc. Stock Quote
Assembly Biosciences, Inc.
ASMB
$2.17 (0.46%) $0.01

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

Related Articles

Motley Fool Returns

Motley Fool Stock Advisor

Market-beating stocks from our award-winning analyst team.

Stock Advisor Returns
373%
 
S&P 500 Returns
122%

Calculated by average return of all stock recommendations since inception of the Stock Advisor service in February of 2002. Returns as of 08/11/2022.

Discounted offers are only available to new members. Stock Advisor list price is $199 per year.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.