What happened

Shares of Gilead Sciences (GILD 0.91%) were jumping 6.7% higher as of 11:21 a.m. EST on Tuesday. The gain came after Morgan Stanley analyst Matthew Harrison upgraded the stock to overweight from equal weight. Harrison set a one-year price target for Gilead of $83, reflecting a premium of 31% above the closing price on Friday. In addition, the U.S. Supreme Court declined to review Merck's (MRK 0.44%) appeal of a lower federal court's decision to overturn a $2.54 billion verdict against Gilead for infringing patients with its hepatitis C drugs Harvoni and Sovaldi. 

So what

The bigger catalyst for Gilead today was definitely Morgan Stanley's upgrade. It wasn't all that surprising that the Supreme Court opted not to take on Merck's case. But it was at least a little surprising that Matthew Harrison expects the biotech stock to soar to $83.

Man wearing a coat and tie with a thumbs up

Image source: Getty Images.

Harrison is certainly more bullish than most Wall Street investors. The average price target for Gilead is a little over $72, which still reflects a double-digit upside compared to the stock's closing price at the end of last week. 

Gilead could meet Harrison's optimistic outlook. However, it won't be easy. COVID-19 therapy Veklury ranked as the company's primary revenue growth driver in the third quarter. Sales growth will likely be harder to come by later this year as more people across the world receive COVID-19 vaccines.

Now what

In just a few weeks, Gilead will announce its fourth-quarter results. Veklury will likely again be the big story. Going forward, though, the biotech's big investments in oncology will need to pay off for Gilead to return to its winning ways of several years ago.