One of the best ways to gain wealth is to get in on the ground floor of something that goes on to become really big. Semiconductors back in the '70s, PC software in the 80s, and the internet in the '90s are great examples. 

But what's something that might be a fit today? Consider cannabis. While the cannabis industry is already growing significantly, it's only in the early innings. There's a realistic chance that investing in the best cannabis companies could create tremendous wealth over time.

Here are three marijuana stocks that could even be millionaire makers.

Cannabis leaf on top of a pile of $100 bills.

Image source: Getty Images.

Ayr Wellness

Ayr Wellness (AYRW.F -5.67%) is something of a rarity among cannabis stocks: It's relatively inexpensive. The multistate cannabis-operator's shares trade at only five times sales, well below nearly every other pot stock on the market.

Even better than its attractive valuation, though, is its growth. The company's sales soared 74% year over year and nearly 23% quarter over quarter in the first quarter of 2021 to $58.4 million. Ayr expects even more impressive growth in Q2.

There's a good reason behind Ayr's optimism. The company recently closed on key acquisitions in Arizona, Florida, and Ohio. It should complete another acquisition in New Jersey this summer. Ayr's business in its other markets of Arizona, Massachusetts, Nevada, and Pennsylvania also continues to grow at a strong pace.

Over the long term, Ayr could become much bigger. CEO Jonathan Sandelman told my Motley Fool colleague Eric Volkman last month that Ayr "love[s] the idea of setting up in neighboring states, when possible." He also said that the company thinks that Florida "has the potential to rival California" if it legalizes recreational marijuana. 

Cresco Labs

Cresco Labs (CRLBF -4.76%) ranks as one of the biggest multistate cannabis operators in the U.S. It's also one of the most attractively valued, with shares trading at a little over four times sales.

The company reported revenue of $178.4 million in Q1, up nearly 169% year over year and almost 10% quarter over quarter. Cresco projects an annualized revenue run rate of more than $1 billion by the end of this year.

Seven of the 10 most heavily populated states in the U.S. have legalized medical and/or recreational cannabis, and Cresco operates in all of them. It's especially strong in California, Illinois, and Pennsylvania.

Cresco's strategy is focused in large part on being the wholesale cannabis leader. That's been a smart approach in other markets, with wholesale delivering higher profit margins than retail. I think that Cresco is poised to become a much bigger winner than it already is as it executes on this wholesale strategy in more markets.

Jushi Holdings

Jushi Holdings (JUSHF -5.64%) stands out as another relative bargain among cannabis stocks. Its shares currently trade at 5.5 times sales.

The company's revenue is growing so fast that Jushi didn't even provide a year-over-year comparison in its first-quarter update. Instead, the company noted that sales soared 29% quarter over quarter to $41.7 million.

Jushi's strong growth is primarily coming from two markets right now -- Illinois and Pennsylvania. However, the company's recent and pending acquisitions in California, Massachusetts, Nevada, and Ohio should make those states more important to its business in the near future.

Perhaps the most intriguing opportunity for Jushi, though, is in Virginia. The state's legal recreational-cannabis market will open in 2024. Jushi already serves the medical cannabis market in the fast-growing northern part of the state, home to nearly 30% of its total population. The company appears to be in a great position to leverage its medical cannabis leadership position to also be a top player in Virginia's recreational market.