Encysive's lead compound is pulmonary hypertension treatment Thelin, a drug that's often compared to Gilead Sciences'
But Glaxo won't have the advantage of competing against a diminutive rival in the E.U. anymore. Encysive leveled the David-and-Goliath battle against Glaxo in the multibillion-dollar pulmonary hypertension market two days ago, when it agreed to be acquired by Pfizer
Thelin sales won't start feeling the effects of competition from ambrisentan for a while. Glaxo still has to negotiate reimbursement pricing among many of the European countries where it will sell the drug, which will go by the brand name Volibris. Last year, Encysive recorded $12 million in worldwide sales and has guided for $40 million to $50 million in sales for 2008.
The pulmonary hypertension drug market is in its infancy and still carries an orphan indication, although it's growing quickly. In fact, Thelin and Volibris are far from the only drugs to treat pulmonary hypertension, a condition that can make walking even a few feet difficult and tiring. Last year, Gilead's U.S. sales of ambrisentan were in the low-double-digit millions.
The E.U. approval of ambrisentan came a little sooner than Encysive and Pfizer probably would have liked, but it was expected, considering the drug's efficacy, safety, and 2007 FDA approval.
Instead, the early approval of ambrisentan is more troublesome for Actelion's Tracleer, the leader in the endothelin receptor antagonist category of pulmonary hypertension treatments. Last year, sales of Tracleer topped $1 billion worldwide, so ambrisentan will bite into Tracleer's sales fortunes much more than it will Thelin's.
More from The Motley Fool
3 Top Stocks That Are Cash Cows
It's not just the cash. It's what these companies do with it that really matters.
Even in This Rich Market, Gilead Sciences, Inc. Is Offering Investors Value
Here's why this biotech stock's single-digit earnings multiple looks more like an opportunity than a trap.
You'll Be Stunned by How Many Cancer Immunotherapies Are Being Developed
But is "the more the merrier" really "the more the messier"?