Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Zalicus (Nasdaq: ZLCS) shares jumped 10% in trading Monday on unusually high volume.

So what: There was not any news from the biopharmaceutical company today, but volume was high in early trading. In less than three hours of trading, more than 2.2 million shares had changed hands compared with a three-month average of 533,000.

Now what: Without any definitive news from the company, this appears to be a speculative move in the stock. The market can take wild turns on this kind of volume, so be careful with this move. This Fool doesn't have the stomach to buy here without positive news from the company.

Interested in more info on Zalicus? Add it to your watchlist by clicking here.