WASHINGTON (AP) -- President Barack Obama presided Monday over the first meeting of his new-look Cabinet in a sobering climate of forced fiscal belt-tightening, urging humane management of spending cuts for communities and families that are "going to be hurting."

Obama said he's continuing to seek out Republican partners to reach a deal to end the so-called "sequester," but there was no sign that a breakthrough was in the works to reverse the $85 billion in budget reductions that went into effect Friday.

"We are going to manage it the best we can to minimize the impact on American families," the president told reporters allowed in for the beginning of the meeting. "It's not the right way to go about deficit reduction."

Obama sat next to his newly confirmed Defense Secretary Chuck Hagel, with new Treasury Secretary Jack Lew across the long oval table, next to Vice President Joe Biden. Obama said his team also planned to discuss other priorities for his second term, including immigration reform, gun control, and expansion of funding for preschool.

Obama's spokesman was more pointed in his comments on sequestration in a briefing preceding the Cabinet meeting. White House press secretary Jay Carney said it's remarkable some Republicans are calling the deep government-wide cuts a win for the conservative tea party, or for Republicans who stood up to the president.

Carney said the cuts go against conventional GOP goals of increasing defense spending and border security. He also said the cuts do nothing to address Republican priorities for long-term deficit reduction or tax reform.

Obama "hopes that having achieved this empty victory, at least as they see it, the Republicans will understand that their goals are being unmet here," Carney told reporters. "So not only are Americans suffering from this, regular folks, but their objectives are being unmet and there's an opportunity to change that dynamic."

The Senate's Republican leader, Mitch McConnell, on Sunday called those cuts modest, and House Speaker John Boehner said he wasn't certain that they will hurt the economy.

"This modest reduction of 2.4 percent in spending over the next six months is a little more than the average American experienced just two months ago, when their own pay went down when the payroll tax holiday expired," McConnell said on CNN's "State of the Union."

"I don't know whether it's going to hurt the economy or not," Boehner said on NBC's "Meet the Press." ''I don't think anyone quite understands how the sequester is really going to work."