In the following video, Motley Fool health-care analyst David Williamson discusses Depomed's (ASRT -4.54%) major FDA advisory committee embarrassment. The company's menopause drug Sefelsa received a nearly unanimous vote against it, not based on risk vs. reward, but on efficacy. Depomed paid $1 million for the opportunity to be reviewed by the panel. In the video, David tells investors how the company could have made such a miscalculation, why it could be a win on the market if the drug were to be approved, but why it's such a long shot that it isn't worth the risk, and what else Depomed has in its arsenal.