The latest health care acquisition rumor is a doozy.

According to multiple news outlets, Pfizer (NYSE:PFE) was in talks with AstraZeneca (NYSE:AZN) to acquire the company for over $100 billion, although the companies apparently broke off talks. Interestingly, this news report kicked off a week of merger and acquisition news hitting the pharma space. This is an interesting possible reversal of the past drive to slim down, with pharma companies focusing in on their core strengths and spinning off divisions instead of seeking more diverse revenue sources. While the merger of Pfizer and AstraZeneca may not come to pass, there's a growing trend of mergers recently, including Actavis and Forest Labs, so perhaps the proposed tie-up isn't as implausible as it appeared at first glance.

In the video below, senior biotech specialist Brian Orelli and health-care bureau chief Max Macaluso give their thoughts on recent megamergers, such as Pfizer-Wyeth and Merck (NYSE:MRK)-Schering-Plough, and discuss why Pfizer might be coveting the British pharma giant.

Brian OrelliMax Macaluso, Ph.D., and The Motley Fool have no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.