What: ZIOPHARM Oncology (NASDAQ:ZIOP) ended Tuesday up about 14% after announcing that it had a study published in Scientific Reports.

So what: The paper shows how eliminating the expression of a protein called human leukocyte antigen-A (HLA-A) using Sangamo Biosciences'(NASDAQ:SGMO) zinc finger nucleases can make it easier to transplant hematopoietic stem cells and restore bone marrow function.

In mice.

ZIOPHARM's press release conveniently leaves out that detail. While it's a nice proof-of-concept study, investors should keep in mind that scientists can treat a lot of diseases in mice that can't yet be treated in humans.

Interestingly Sangamo Biosciences ended the day down 6%. Admittedly, getting the technique to work isn't as important to Sangamo Biosciences' valuation, but the drop still suggests ZIOPHARM's investors might be overreacting just a bit.

Now what: Finding matched donors for hematopoietic stem cells transplants is difficult because there are multiple components -- HLA-A, HLA-B, HLA-C, and HLA-DRB1 -- that need to match to avoid rejecting the transplant. By removing HLA-A, ZIOPHARM is trying to make off-the-shelf treatments that can treat a wide variety of patients.

It's certainly good that researchers at ZIOPHARM and its academic partner The University of Texas MD Anderson Cancer Center were able to get the system working in mice, but investors should still be cautious until they can show that the process works in humans.