With profits at its back, one-hit wonder Onyx Pharmaceuticals
Yesterday, the formerly pipeline-less drugmaker announced its second license in the last few months. In November, it licensed a pre-clinical drug from England's BTG International, and yesterday it licensed two more drugs from privately held S BIO. Both compounds -- one phase 1 and one preclinical -- are JAK2 inhibitors. JAK2 seems to be involved in a wide range of diseases, including cancer and autoimmune diseases, so affecting how that protein works makes a tempting target.
The drugs are behind other JAK2 inhibitors being tested against myelofibrosis, a disease that inhibits bone marrow production of blood cells -- Exelixis'
My biggest problem with Onyx has always been that, without a pipeline, it was completely reliant on Nexavar for income. I realize that it's not easy developing a second major hit -- just ask fellow class members Elan
I'm not quite ready to jump on the Onyx bandwagon yet, however. With its new pipeline drugs still in the early stages of development, Onyx's near- and even medium-term prospects rely solely on sales of Nexavar. The drug is approaching saturation for treating liver and kidney cancer, so it'll have to get approved for another indication to see sales really take off again. Unfortunately, Nexavar has failed to show an effect in skin and lung cancers, so further growth is far from guaranteed.
While yesterday's developments aren't a reason to run out and buy Onyx, the company is looking better and is certainly worth keeping an eye on.
