When transplants are performed, patients have to take drugs to suppress the immune system, keeping it from rejecting the new cells it sees as foreign. Unfortunately, the suppression can also leave patients vulnerable to attacks from routine viruses (such as cytomegalovirus) that the immune system usually handles easily.

To control the cytomegalovirus, Vical (Nasdaq: VICL) has developed TransVax, and now it has some big-pharma firepower to push the drug through clinical development. Vical announced yesterday that it had licensed TransVax to Astellas Pharma for $35 million in the near term, and potentially another $95 million if the drug hits development milestones.

Total payments of $130 million aren't really all that much for a phase-3-ready compound; consider that Micromet's (Nasdaq: MITI) preclinical deal with Amgen (Nasdaq: AMGN) had a price tag of $975 million for two drugs. But it looks like Vical might have traded some milestone payments for a higher royalty rate. Instead of "tiered royalties that can reach double-digits," as is typical for licensing deals, Vical said it's due double-digit royalties -- as in at least 10% from day one of the launch.

While the vaccine will have a much smaller market than vaccines like Pfizer's (NYSE: PFE) Prevnar, Merck's (NYSE: MRK) Gardasil, or GlaxoSmithKline's (NYSE: GSK) Cervarix, it'll likely come with a much higher price tag to make up for the limited patient population. For instance, AstraZeneca's (NYSE: AZN) Synagis, which is used to prevent infections of the respiratory syncytial virus in premature babies, is still a blockbuster.

Of course, talk of sales and royalties is a little premature at this point. TransVax needs to prove successful in its yet-to-be-started phase 3 trial before we can transplant those milestone and royalty payments to the revenue line.

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Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. Click here to see his holdings and a short bio. The Motley Fool owns shares of GlaxoSmithKline. Motley Fool newsletter services have recommended buying shares of GlaxoSmithKline and Pfizer. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool's disclosure policy is an organ donor and thinks you should be, too.