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Here's Why Adverum Biotechnologies Is Soaring Today

By Cory Renauer – May 6, 2020 at 12:53PM

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The company's experimental gene therapy for a common cause of blindness showed promise in a clinical trial.

What happened

Shares of Adverum Biotechnologies (ADVM 2.50%), a clinical-stage gene therapy company, jumped today in response to some compelling clinical trial results. Positive interim data from a study with the company's lead candidate, ADVM-022, has lifted the stock 12.2% as of 12:34 p.m. EDT on Wednesday.

So what 

Adverum has been treating patients who require frequent anti-VEGF injections to slow the progression of wet age-related macular degeneration (AMD) with different sized doses of its lead candidate ADVM-022. A single injection of ADVM-022 at the lowest dose tested helped four out of six patients go for a median of 36 weeks without requiring rescue injections. The same dose helped four out of five patients with a 20-week followup avoid rescue injections. 

Cash money raining down on a smiling investor.

Image source: Getty Images.

Among six patients treated with a higher dosage, none have required anti-VEGF rescue injections 60 weeks after a single injection of Adverum's gene therapy candidate.

Now what

At the moment, Eylea from Regeneron (REGN -0.29%) is the top-selling anti-VEGF injection and it's on pace to generate $7.4 billion in sales this year. Government payers tired of paying for regular Eylea injections could make ADVM-022 a go-to solution for growing numbers of older adults losing their vision to AMD and related disorders. 

As a once-and-done injection, Adverum needs to set a hefty price for ADVM-022 and it's going to take more than 60-week data to convince payers to take a chance on a longer-term solution. Adverum's AMD candidate could turn a multi-billion market for anti-VEGF drugs on its head if it continues to impress, but there's still a long road ahead.

Cory Renauer has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

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Stocks Mentioned

Adverum Biotechnologies, Inc. Stock Quote
Adverum Biotechnologies, Inc.
$1.02 (2.50%) $0.03
Regeneron Pharmaceuticals, Inc. Stock Quote
Regeneron Pharmaceuticals, Inc.
$732.99 (-0.29%) $-2.14

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