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This 2020 Biotech IPO Is Poised to Break Out in 2021

By Patrick Bafuma - Apr 2, 2021 at 6:15AM

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Revolution Medicines' leading compound is shaping up to be a platform in a pill.

The notoriously difficult-to-target RAS cancer mutations may soon have a new enemy, and 230,000 U.S. cancer patients with RAS mutations may soon have good news. Revolution Medicines (RVMD -5.77%) and its lead compound, RMC-4630, are looking to become the backbone of treatment for RAS-driven cancers -- an opportunity worth more than $20 billion in the U.S. alone.

Currently in phase 2 trials, RMC-4630 is an oral therapy that Revolution's management team believes can be used either as a monotherapy or in combination treatment for cancer patients with tumors containing RAS mutations. In early trials, RMC-4630 has shown anti-tumor activity across multiple solid tumors, and there are multiple clinical readouts coming in the next year that may push Revolution Medicines even further past the 55%-plus gains investors have enjoyed since the company's February 2020 IPO.

A baseball resting in a baseball mitt next to a bat in the grass.

Image source: Getty Images.

Multiple shots with big partners

This April, at the American Association for Cancer Research Conference (or AACR21, for short), we will get a preview of more dose-escalation and safety data regarding monotherapy treatment of RMC-4630 in solid tumors. Later in 2021, the company will report clinical data for combination treatment with Amgen's sotorasib for non-small cell lung cancer. And in 2022, management expects to report data on combination treatment with Roche's cobimetinib in relapsed/refractory solid tumors with KRAS mutations. Additional early phase studies looking at RMC-4630 in combination with Merck's Keytruda for solid tumors and in combination with AstraZeneca's osimertinib in non-small-cell lung cancer are under way as well. That's a lot of players on base, and a lot of heavy-hitting partners.

The potential market is huge

With precision oncology medications typically fetching north of $100,000 per patient per year and a total addressable RAS market in the U.S. alone of 230,000 patients, that's an impressive $23 billion of potential. Revolution Medicines currently sports a $3.6 billion market cap, which makes it look cheap compared with peers; consider Mirati Therapeutics' $9 billion market cap, and the fact that Mirati's lead compound, adagrasib, targets only a subset of RAS mutations -- about 30,000 patients in the U.S. annually.

This sizable total addressable market has not gone unnoticed by big pharma, with Revolution Medicines already securing a deal with Sanofi (SNY 0.43%) for RMC-4630. Sanofi agreed to cover all research and development (R&D) costs for the program -- likely accelerating its development -- while Revolution Medicines gave up worldwide rights to the drug in exchange for royalties in the high single digits to the mid-teens and a 50/50 split on U.S. profits and losses. Given that Revolution Medicines is looking to make RMC-4630 a backbone for the treatment of all 230,000 oncology patients in the U.S. with RAS-driven cancer, many larger pharmaceutical companies are likely watching closely, and investors will want to do the same.

Biotech investors looking for a home run may want to take a look at Revolution Medicines at its current $3.3 billion market cap and see whether big-swinging RMC-4630 can knock phase 2 trials out of the park. If so, both investors and patients may win big in the end.

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Stocks Mentioned

Revolution Medicines, Inc. Stock Quote
Revolution Medicines, Inc.
RVMD
$15.67 (-5.77%) $0.96
Merck & Co., Inc. Stock Quote
Merck & Co., Inc.
MRK
$93.96 (0.14%) $0.13
Sanofi Stock Quote
Sanofi
SNY
$55.67 (0.43%) $0.24
AstraZeneca PLC Stock Quote
AstraZeneca PLC
AZN
$66.56 (0.23%) $0.15
Roche Holding AG Stock Quote
Roche Holding AG
RHHBY
$43.09 (2.94%) $1.23
Mirati Therapeutics, Inc. Stock Quote
Mirati Therapeutics, Inc.
MRTX
$59.76 (-6.01%) $-3.82

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

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