Wells Fargo (NYSE:WFC) is undoubtedly seen as the strongest big U.S. bank, but investors should always be reevaluating their positions to see if their investment thesis has changed. Knowing when to sell is always a difficult decision, but shareholders who can anticipate game-changing impacts are rewarded.

In this video, Motley Fool banking analysts David Hanson and Matt Koppenheffer discuss potential scenarios that might signal that its time to sell your shares of Well Fargo. 

David Hanson has no position in any stocks mentioned. Matt Koppenheffer has no position in any stocks mentioned. The Motley Fool recommends Wells Fargo. The Motley Fool owns shares of Wells Fargo. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.