Editor's Note: The article has been corrected to remove certain incorrect information about Regeneron Pharmaceuticals' Eylea. The Fool regrets the error.

Biotech stocks can often make big moves after reporting trial data, but it's FDA drug approvals or denials that can really make stocks in the industry pop or drop. For that reason, we asked three Motley Fool experts what FDA decisions they're most excited about. Read on to learn which three companies and drugs are on their radar.

Source: Celgene Corporation.

Todd Campbell: It's not often that a top-selling blockbuster drug can have an opportunity to see its sales grow dramatically, but that's exactly what could happen to Celgene Corporation's (NASDAQ:CELG) multiple myeloma drug Revlimid if the FDA grants approval for its use as a first-line treatment this month.

Revlimid is already selling at a $5 billion annualized clip, but that success stems from its market share leadership as a second-line multiple myeloma drug. If the FDA approves Revlimid for newly diagnosed patients, revenue could march handily higher this year. Although the FDA could always decide to say no, results during phase 3 trials seem to indicate that the FDA will say yes. In those trials, Celgene reported that there was nearly a 30% reduction in risk of disease progression or death in patients treated with Revlimid and dexamethasone versus the control arm. 

If the FDA does grant Celgene approval to market Revlimid as a first-line therapy, chances are that Celgene will have a better shot at hitting its targets of Revlimid sales of between $5.6 billion and $5.7 billion this year and Revlimid sales of $7 billion by 2017. That suggests that investors should keep a close eye on the FDA on Feb. 22, the date on which the agency is set to make its decision.

Brian OrelliVertex Pharmaceuticals (NASDAQ:VRTX) has a couple of FDA decisions coming up, with radically different potentials to increase the biotech's revenue.

First, the agency is expected to rule by March 17 on expanding the use of Vertex's cystic fibrosis drug, Kalydeco, to treat children ages 2 to 5 who have the G551D or one of the eight additional gating mutations.

Kalydeco is already on the market for patients 6 and older with those same mutations. In all of North America, Europe, and Australia, Vertex estimates there are only 2,600 cystic fibrosis patients with the mutations, so this particular expansion isn't going to move the revenue needle much.

Vertex's lumacaftor combined with Kalydeco, on the other hand, will have a major effect on revenue. The company estimates there are 8,500 people in the U.S. alone age 12 and up with the F508del mutation that responds to the combination treatment. With the FDA approval, Vertex will quadruple the number of cystic fibrosis patients it can treat even before adding in an EU approval that should come toward the end of the year.

The FDA has a goal of making a decision on the combination treatment by July 5, but if you're looking to buy ahead of the decision, I wouldn't wait too long. When Kalydeco was first approved in 2012, the FDA made its decision two and half months before its PDUFA goal date. 

Brian Orelli has no position in any stocks mentioned. Cheryl Swanson owns shares of Celgene. Todd Campbell is long Celgene. The Motley Fool recommends Celgene and Vertex Pharmaceuticals. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.