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Why Advaxis, Inc. Shares Are Soaring 16% Today

By Todd Campbell - Mar 21, 2016 at 1:51PM

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A positive trial in canines with bone cancer could have implications for human cancer patients, too.


What: After reporting intriguing data for its cancer therapy in dogs that could have implications for human cancer patients, shares in Advaxis, (ADXS 10.46%) are rallying 15% at 2:00 p.m. EST Monday.

So what: The clinical stage biotech's ADXS-HER2 is being evaluated as a cancer treatment for osteosarcoma, the most common primary bone tumor found in dogs and the most common bone cancer in children and teens.

In the canine study, 18 dogs with surgically treated osteosarcoma were given the immunotherapy and 15 of those dogs showed an antigen-specific response within six months of receiving ADXS-HER2. Importantly, ADXS-HER2 administration resulted in a median survival time of 956 days, which is far superior to the 423 median days historically associated with this cancer.

Now what: ADXS-HER2 is one of Advaxis listeria-based immunotherapies. These therapies are designed to deliver an engineered variation of listeria directly to tumors so that the immune system can identify the tumor and destroy it.

The news could support a conditional launch by Artana Therapeutics (PETX), which has licensed the drug for use in animal health, later this year.

However, we're still a ways away from this drug being proven effective in humans. Advaxis is evaluating three listeria bioengineered therapies in trials, the most advanced of which in human trials is axalimogene filolisbac, a treatment for cervical cancer, head and neck cancer, and anal cancer. It's also working on ADXS-PSA, a drug that's being studied for use alongside Merck & Co's PD-1 drug, Keytruda, in prostate cancer patients.


Overall, the concept of using immunotherapies to battle back against cancer is immensely intriguing and that makes this company one worth adding to a watch list to keep tabs on. 

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Stocks Mentioned

Merck & Co., Inc. Stock Quote
Merck & Co., Inc.
$92.51 (0.68%) $0.62
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Advaxis, Inc. Stock Quote
Advaxis, Inc.
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