Not many companies have monopolies, though some get pretty close. That list includes Russian telecom giant Mobile TeleSystems (NYSE:MBT), biotech player Gilead Sciences, Inc. (NASDAQ:GILD), and tobacco maker Altria Group, Inc. (NYSE:MO). Each one has a slightly different virtual monopoly, and they clearly have vastly different businesses. But if you are looking for income from seriously entrenched industry players, you'll want to get to know this trio of high-yielders.

A big company from the land of large companies

Rich Smith (Mobile TeleSystems): Russia's Public Joint-Stock Company Mobile TeleSystems isn't exactly a monopoly, but with annual revenue of $7.7 billion, it's easily the biggest telecom provider in the Russian Federation (according to data from S&P Global Market Intelligence).

Approximately 92% of MTS's revenue comes from Russia -- $7 billion annually, versus $5.5 billion for No. 2 MegaFon and $4.7 billion for Veon, which round out Russia's Big 3 telcos. And with a much bigger business comes much bigger profit margins. S&P Global data show MTS reaping a monster 21.5% operating profit margin from its business, versus Veon's 18.1% and Megafon's 16.2%.

Two people looking at a computer with a graph on the screen.

Image source: Getty Images

These margins helped Mobile TeleSystems earn $891 million in profit last year, but on a $9.6 billion market capitalization, that means investors can acquire a piece of this dominant telecom for the low, low price of just 10.8 times earnings. Is that a fair price?

I think so. With almost all of its profit translated immediately into dividends (a payout ratio of 92%), MTS pays its shareholders a 10.5% dividend yield. This in and of itself would come close to justifying the P/E ratio. But MTS is also growing strongly despite repeated rounds of sanctions being imposed on Russia from abroad. Analysts who follow the company's fortunes predict MTS will grow earnings at 14% annually over the next five years.

Which just goes to show -- even just a "virtual" monopoly can make for a mighty rewarding investment.

A high-yield biotech with substantial market share? Yeah, that's a thing

Sean Williams (Gilead Sciences): Though high-yield stocks with virtual monopolies don't grow on trees, you can probably find one in plain sight in the biotech industry with Gilead Sciences. For years, Gilead Sciences has been the dominant market share leader in hepatitis C virus (HCV) therapies, and currently maintains just over half of all market share in HIV treatments, which places it in the neighborhood of 30-percentage points ahead of next-closest competitor, GlaxoSmithKline

Nowadays, the bulk of the excitement surrounding Gilead revolves around its HIV therapeutics, which grew to $3.33 billion in first-quarter sales, up modestly from the $3.27 billion reported in the year-ago period. Gilead's research and development into new HIV antiviral products regularly cycles out its older HIV products in favor of next-generation therapies. Currently, its TAF-based drugs like Genvoya, Descovy, and Odefsey, are doing the heavy lifting, so to speak. Since there is no cure for HIV/AIDS, Gilead's HIV line of therapies, which is designed to dramatically slow the rate of virus reproduction, are often used for long periods of time, providing reliable and consistent cash flow. 

Meanwhile, Gilead's HCV portfolio had once been its crown jewel. However, with competition finally hitting pharmacy shelves, and the low-hanging fruit having been reached -- i.e., the sickest patients have been treated -- HCV sales have struggled mightily. The thing to remember with hepatitis C is that the market extends well beyond the United States. After all, the World Health Organization estimated in March 2018 that 71 million people worldwide carry the hepatitis C virus. While margins won't be nearly as robust in overseas markets as they've been in the U.S., a market does still exist for Gilead's core HCV products.

Understandably, Gilead is something of a work in progress at the moment. Quarterly HCV sales have proven erratic, and it'll likely be years before the company's recent acquisitions pay dividends. Then again, Gilead ended its most recent quarter with $32.1 billion in cash, which is quite the war chest for a growth-seeking biotech, and it's paying investors a healthy 3.5% yield while they hunker down for a turnaround. Though Gilead Sciences is far from the sure thing it once seemed to be, it's a value and income stock with clear market share advantages that may still be worth a closer look.

This sin stock has a lock on customers

Reuben Gregg Brewer (Altria Group, Inc.): Owning a tobacco stock may not be right for everyone, but government regulation has effectively closed the U.S. market to new competition. Which has provided Altria and its tobacco brands, including iconic Marlboro, a huge advantage in an industry facing a slow and steady decline. With roughly 50% market share in cigarettes and smokeless tobacco products, Altria has a virtual monopoly in the markets it serves.

Altria has been using its dominant market position to return value to shareholders via stock buybacks and a big dividend (the company targets an 80% of adjusted earnings payout ratio). The hefty 5% yield, however, is backed by 49 years of consecutive annual dividend hikes, so this is no fly by-night company using a fat dividend to lure in investors. How has Altria managed to keep pushing sales results, and dividends, higher? Because of the nature of its products and the lack of new competition Altria has been able to increase the prices it charges over time, more than offsetting the impact from slowly declining demand.   

MO Revenue (Annual) Chart

Data source: MO Revenue (Annual) data by YCharts.

Altria is, effectively, a cash cow investment. That said, it isn't waiting for its business to simply die off (something that will likely take decades to happen, by the way). It is also investing in new technology like vaping and burnless tobacco products (its iQOS line). Investments like these should help to extend the company's dominant market position as it leverages its leading brand names in new areas.   

If you can't handle a so-called "sin" stock, don't buy Altria. But it certainly has a virtual monopoly on U.S. tobacco and is using that to reward investors with big dividends.

Quite the collection of virtual monopolists 

Monopolies are usually quite hard to find, but Mobile TeleSystems, Gilead Sciences, and Altria get very close. Even though these companies span the gamut from telecom to healthcare to tobacco, each has a dominant position in key markets that they are using to reward investors and build for the future. Take some time to get to know these high-yielders and you might end up adding one, or more, to your portfolio.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.