The commercial launch of Casgevy continues to gain momentum, with Vertex leading the charge. Meanwhile, CRISPR Therapeutics is working to advance several other gene-editing programs.
The company's pipeline includes two allogeneic chimeric antigen receptor T cell (CAR-T) therapies in clinical testing -- CTX112 and CTX131. Allogeneic (which means involving genetically different tissues or cells) CAR-T therapies are often referred to as "off-the-shelf" because they don't require a patient's own cells to be genetically edited and instead use cells from healthy donors.
CRISPR Therapeutics is evaluating two in vivo gene-editing therapies (where gene editing is performed inside the body) in early stage clinical studies. The company is also conducting clinical testing of an experimental therapy for treating type 1 diabetes, with an update on this program expected in 2025.