Please ensure Javascript is enabled for purposes of website accessibility

Better Buy: EXACT Sciences Corporation vs. Illumina

By Brian Feroldi – Nov 16, 2018 at 3:59PM

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

Which of these two fast growers in the smarter choice for new money today?

Healthcare products remain in demand in good times and in bad. That's a big reason the sector is a great place for investors to hunt for stock ideas.

In today's matchup, we're pitting cancer detection specialist EXACT Sciences Corporation (EXAS -3.69%) against DNA-sequencing giant Illumina (ILMN -3.72%). Which of these two long-term winners is the better choice for investors today?

Money with arrows pointing out in different directions

Image source: Getty Images.

The case for EXACT Sciences

Colon cancer is easily treatable when it's caught early, but 50,000 Americans still die from the disease each year. Why? The primary reason is that adherence to the gold standard diagnostic method -- an invasive and expensive test called a colonoscopy -- is abysmal.

Exact Sciences is on a mission to change all of that with its innovative Cologuard test. Users simply deposit a stool sample in the box from the comfort of their own home and send the test in for analysis. Then the patient's doctor receives a full report within just a few days and determines the next steps.

The appeal of using Cologuard has lead to strong demand from patients, payers, and healthcare providers alike. Exact Sciences' revenue and stock price have risen rapidly in response.

Even with the prosperity, there's ample reason to believe that Exact Sciences' torrid growth rate can continue from here:

  • The American Cancer Society (ACS) recently recommended that colorectal cancer screening should begin at age 45 for people who have an average risk of developing the disease. That's five years younger than its previous guidance and should help to expand the company's addressable market. 
  • The company signed a marketing deal with pharma giant Pfizer (PFE -0.61%) to co-promote Cologuard. The deal calls for Pfizer to conduct hundreds of thousands of sales call each year and throw an additional $65 million at marketing the product. 
  • Exact Sciences is developing products that can utilize its technology on other forms of cancer, such as liver cancer.
  • The company believes it has only captured about 2% of its addressable market today.

These factors explain why Exact Sciences' management team is calling for revenue to jump from an expected $435 million in 2018 to $700 million or so next year. With so many growth irons in the fire, it doesn't take a lot of imagination to believe that Exact Sciences' stunning growth rates will continue for the foreseeable future. 

Offsetting that optimism is the fact that Exact Sciences is still burning through capital and currently trades for more than 21 times sales. Those facts might act as headwinds against future appreciation.  

The case for Illumina

Illumina is the far-and-away leader in the genomic sequencing industry. The company boasts the most advanced technology that allows researchers to sequence a genome for a rock-bottom cost. The company's technological advantage has allowed it to hold a commanding market share for years. Best of all, the company employs a razor-and-blade business model that makes its financial statements highly reliable. These factors have worked together to mint long-term shareholders an absolute fortune.

Illumina continues to put up impressive numbers to this day. Sales expanded at a 19% pace in the most recent quarter thanks to the strength of consumable sales. Adjusted earnings grew by an even more impressive 37% thanks to favorable operating leverage.

But is this growth story played out? I think there's reason to believe that the opposite is true for a number of reasons:

  • The company is in the middle of rolling out its Novaseq system. This product promises to enable researchers to sequence a genome for as little as $100. 
  • Direct-to-consumer genomics services are just now starting to take off thanks to companies like, 23andMe, and Helix. For now, these services mostly help with genealogy, but there's ample room for innovation, especially as it relates to genetic diseases.
  • Illumina recently purchased Pacific Biosciences of California (PACB -4.27%), one of its key rivals. This one move broadens its suite of products and removes a key competitor.
  • Illumina recently spun off a company that is focused on early cancer detection called Grail. While it's still early days for the company, success would be a financial windfall for Illumina.

With these things added together, Wall Street projects that Illumina's profits will grow in excess of 22% annually over the next five years. That's blazing-fast for a relatively mature business.

The only knock I see is that Illumina also trades for a nosebleed valuation. Shares are trading for more than 50 times next year's earnings estimates, so the prosperity might already be priced in.

The better buy

There's an argument to be made that both of these companies deserve a spot in a growth investor's portfolio, but if forced to choose today, I'd happily go with Illumina. The company is at the top in an industry poised for rapid growth, and it gushes cash thanks to its razor-and-blade business model. That's a rare combination that any investor should find attractive.

Brian Feroldi has no position in any of the stocks mentioned. The Motley Fool owns shares of and recommends Illumina. The Motley Fool recommends Pacific Biosciences of California. The Motley Fool has a disclosure policy.

Invest Smarter with The Motley Fool

Join Over 1 Million Premium Members Receiving…

  • New Stock Picks Each Month
  • Detailed Analysis of Companies
  • Model Portfolios
  • Live Streaming During Market Hours
  • And Much More
Get Started Now

Stocks Mentioned

Illumina, Inc. Stock Quote
Illumina, Inc.
$193.81 (-3.72%) $-7.48
Exact Sciences Corporation Stock Quote
Exact Sciences Corporation
$33.17 (-3.69%) $-1.27
Pfizer Inc. Stock Quote
Pfizer Inc.
$44.16 (-0.61%) $0.27
Pacific Biosciences of California, Inc. Stock Quote
Pacific Biosciences of California, Inc.
$5.60 (-4.27%) $0.25

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

Related Articles

Motley Fool Returns

Motley Fool Stock Advisor

Market-beating stocks from our award-winning analyst team.

Stock Advisor Returns
S&P 500 Returns

Calculated by average return of all stock recommendations since inception of the Stock Advisor service in February of 2002. Returns as of 09/30/2022.

Discounted offers are only available to new members. Stock Advisor list price is $199 per year.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.