1. Cresco Labs
Related investing topics
FAQ
About the Author
Keith Speights has no position in any of the stocks mentioned. The Motley Fool recommends Cresco Labs and Green Thumb Industries. The Motley Fool has a disclosure policy.
Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.
CBD stocks are shares of publicly traded companies that are involved in the processing and distribution of CBD or that provide tools and services to other companies in the CBD industry. CBD, or cannabidiol, is a chemical found in the cannabis plant. Sometimes, the best time to invest in a relatively new market is after the initial euphoria has evaporated. Could that be the case with investing in CBD stocks? Maybe.
The U.S. legalized hemp-derived CBD at the federal level with the 2018 Farm Bill. The mere anticipation of this legislation's passage stoked investor interest in companies in the CBD industry.
Although federal legalization served as a key milestone, the U.S. Food and Drug Administration (FDA) chose to exclude CBD from food supplements. As a result, the CBD opportunity in the U.S. hasn't lived up to investors' lofty ambitions.
The CBD industry faces another big challenge in 2026. A continuing resolution passed by the U.S. Congress in November 2025 made significant changes to federal hemp product regulations.
Although the CBD market isn't as attractive as it once was due to the uncertainties created by these changes, investors may still want to consider the following four CBD stocks.
Cresco Labs (CRLBF -1.65%) is an Illinois-based cannabis operator that markets recreational and medical cannabis products in eight states. The company is more than just a cannabis producer and retailer. Cresco also markets branded cannabis products containing CBD, including its Wonder gummies. It commands the leading market share in multiple markets of $1 billion or more.
Cresco has grown significantly through the years, both organically and through acquisitions, and it consistently generates solid free cash flow. The company also stands to benefit from tax changes related to the federal rescheduling of marijuana.
Perhaps the biggest knock against Cresco is that the company can't list its shares on a major U.S. stock exchange as long as marijuana remains illegal at the federal level. However, Cresco has proven that it can still attract investors through the U.S. over-the-counter (OTC) markets.

Like Cresco Labs, Green Thumb Industries (GTBIF -3.46%) is a U.S. cannabis operator based in Illinois. The company has dispensaries in 14 states as of mid-2026. Green Thumb markets multiple brands in its Rise dispensaries, including Rythm, which offers a lineup of CBD products.
The company is profitable and generates positive cash flow. It continued to grow, expanding into Minnesota in 2025 and adding 12 new locations throughout the U.S., bringing its total to 113.

You might be surprised to find a pharmaceutical stock listed among the top CBD stocks to consider. But Jazz Pharmaceuticals (JAZZ +0.53%) has a direct and important connection to CBD. In 2018, the company's Epidiolex became the first CBD product made from the cannabis plant to win FDA approval.
Jazz actually didn't own Epidiolex at that time. It acquired GW Pharmaceuticals, which developed the CBD drug to treat epileptic seizures, for $6.7 billion in 2021. Epidiolex generated annual sales of $1.1 billion in 2025. Sales continue to pick up, as the drug is now approved in more than 35 countries outside the U.S.
Jazz also has other growth drivers in its lineup. Sleep disorder drug Xywav is gaining momentum. The company also launched its biliary tract cancer drug Ziihera in December 2024, and its newest product, Modeyso, used to treat diffuse midline glioma, was granted FDA approval in August 2025.

Trulieve Cannabis (OTC:TCNNF) is a Florida-based cannabis operator. It has retail dispensaries in eight states and cultivation and processing facilities in seven states. The company is especially dominant in its home state's medical cannabis market. Roughly two-thirds of Trulieve's retail locations are in Florida. Trulieve also has leading market positions in Arizona and Pennsylvania.
Like Cresco Labs and Green Thumb Industries, Trulieve generates most of its revenue from cannabis sales. However, it also markets CBD products, including tinctures.
Trulieve experienced a setback when Florida voters rejected a constitutional amendment in November 2024 that would have legalized recreational marijuana. The amendment required 60% approval to pass, but it received only around 56%.
However, supporters plan to continue pushing for the legalization of recreational marijuana. Trulieve could still have a major growth opportunity in its home state in the future.
Follow these steps to invest in CBD stocks:
The benefits of investing in CBD stocks include:
However, there are also several risks associated with investing in CBD stocks, including:
The primary criterion for selecting these four stocks was that they be actively involved in the CBD industry. However, CBD products didn't have to be the companies' main source of revenue.
Another factor was market cap. Only companies with market caps of at least $200 million were considered.
Market leadership and growth prospects were also important factors in the selection process. Each of the four stocks ranks among the leaders in its respective market and should have good long-term growth potential.
Risk-averse investors will probably be better off avoiding CBD stocks, as these stocks can be highly volatile. It's also best to consider buying CBD stocks only if you have a long-term investing horizon.
CBD stocks could be especially attractive to investors whose portfolios are heavily weighted with stable, defensive holdings.

| Name and ticker | Current price | Market capMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary. |
|---|---|---|
| Cresco Labs (OTC:CRLBF) | $0.77 | $290.5 million |
| Green Thumb Industries (OTC:GTBIF) | $7.26 | $1.6 billion |
| Jazz Pharmaceuticals Plc (NASDAQ:JAZZ) | $239.32 | $15.0 billion |
| Trulieve Cannabis (NYSE:TRLV) | $8.63 | $1.7 billion |