Top ETFs Tracking CRISPR Gene Editing

These exchange-traded funds track companies in this biotech space.

By Keith Speights – Updated Jun 18, 2025 at 1:26 PM | Fact-checked by Frank Bass

Key Points

Several ETFs focus on CRISPR gene editing, including ARKG and GNOM.
ARKG owns shares in companies developing CRISPR therapies such as CRISPR Therapeutics.
WDNA tracks companies transformed by genetics and biotechnology, holding CRISPR stocks.

By now, many investors have probably heard enough about CRISPR (clustered repeating interspaced short palindromic repeats) to be relatively familiar with the idea. And they likely know that gene-editing technology has the potential to change the treatment of many diseases by modifying DNA to correct mutations. CRISPR could even cure diseases in some cases.

DNA with a section separated from the main part. — Image source: Getty Images.

But some investors might not be familiar with the exchange-traded funds (ETFs) tracking gene-editing stocks. There are now several ETFs that focus largely on CRISPR and gene editing in general.

Best CRISPR and gene-editing ETFs

Quite a few biotech ETFs are available for investors to buy. The number of CRISPR and gene-editing ETFs, however, is more limited. Here are the top five ETFs that focus on CRISPR gene editing.

Data source: ETF websites as of June 13, 2025.
ETF	Expense Ratio
ARK Genomic Revolution ETF (NYSEMKT:ARKG)	0.75%
Global X Genomics & Biotechnology ETF (NASDAQ:GNOM)	0.5%
Invesco Dynamic Biotechnology & Genome ETF (NYSEMKT:PBE)	0.58%
iShares Genomics Immunology and Healthcare ETF (NYSEMKT:IDNA)	0.47%
Wisdom Tree BioRevolution Fund (BATS:WDNA)	0.45%

1. ARK Genomic Revolution ETF

ARK Genomic Revolution ETF is one of several ETFs established by Cathie Wood's ARK Invest. It's an actively managed ETF that focuses on companies that stand to benefit from incorporating genomics into their businesses. Although the fund isn't limited to CRISPR and genome-editing stocks, there are several in its portfolio.

The ETF's second-largest holding is CRISPR Therapeutics (CRSP -7.95%), which is a pioneer in CRISPR gene editing. ARK Genomic Revolution ETF also owns shares of other drugmakers with CRISPR therapies in development or on the market, including Beam Therapeutics (BEAM -9.54%), Intellia Therapeutics (NTLA -6.53%), Regeneron Pharmaceuticals (REGN +1.19%) (which is partnering with Intellia), and Vertex Pharmaceuticals (VRTX +0.58%).

Vertex and CRISPR Therapeutics won U.S. Food and Drug Administration (FDA) approval for CRISPR gene-editing therapy Casgevy in December 2023 as a treatment for sickle cell disease. The two partners followed up in January 2024 by securing FDA approval for the therapy in treating transfusion-dependent beta-thalassemia.

2. Global X Genomics & Biotechnology ETF

Global X Genomics & Biotechnology ETF is run by the South Korean investment firm Mirae Asset Financial Group. This ETF looks for companies that should benefit from advances in genomics, including breakthroughs in gene editing and genomic sequencing.

GNOM currently owns 49 stocks. Five of them -- CRISPR Therapeutics, Vertex Pharmaceuticals, Intellia Therapeutics, Beam Therapeutics, and Verve Therapeutics (NASDAQ:VERV) -- market or are developing CRISPR gene-editing therapies. Two other holdings, Genscript and Agilent (A -0.07%), offer CRISPR products and services to drug developers and researchers.

3. Invesco Dynamic Biotechnology & Genome ETF

The Invesco Dynamic Biotechnology & Genome ETF seeks to track an index of 30 U.S. biotechnology and genome companies. Not all of these companies focus on CRISPR or other types of gene editing, but several do.

Among PBE's top 10 holdings, two have connections with gene editing: Vertex Pharmaceuticals and Gilead Sciences (GILD -1.10%). Vertex partnered with CRISPR Therapeutics to market CRISPR gene editing therapy Casgevy. Gilead teamed up with Sangamo Therapeutics (SGMO -1.07%) to develop cancer cell therapies using Sangamo's zinc-finger nuclease (ZFN) gene-editing method, an older technology than CRISPR.

4. iShares Genomics Immunology and Healthcare ETF

The iShares Genomics Immunology and Healthcare ETF attempts to track an index of companies in developed and emerging markets that focus on genomics, immunology, and bioengineering. It currently owns positions in 51 pharmaceutical and biotech stocks.

This ETF's holdings include five previously mentioned stocks with CRISPR gene-editing ties that are owned by the other ETFs on the list: CRISPR Therapeutics, Verve Therapeutics, Beam Therapeutics, Intellia Therapeutics, and Regeneron Pharmaceuticals.

5. WisdomTree BioRevolution Fund

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About the Author

Keith Speights is a contributing Motley Fool healthcare analyst covering publicly traded companies across pharmaceuticals, biotechnology, medical devices, technology, and marijuana. Prior to The Motley Fool, Keith was CEO of Constant Care Technology, a healthcare technology company; vice president of American HealthTech, a healthcare software company; and a director of operations for Blue Cross Blue Shield of Mississippi, a health insurer. He holds a B.S. in Industrial Engineering from Mississippi State University.

TMFFishBiz

Keith Speights has positions in Vertex Pharmaceuticals. The Motley Fool has positions in and recommends Beam Therapeutics, CRISPR Therapeutics, Gilead Sciences, Intellia Therapeutics, Regeneron Pharmaceuticals, and Vertex Pharmaceuticals. The Motley Fool recommends AstraZeneca Plc. The Motley Fool has a disclosure policy.